Results 31 to 40 of about 30,070 (260)
Myelodysplastic/Myeloproliferative Neoplasms [PDF]
AbstractMyelodysplastic/myeloproliferative neoplasms (MDS/MPNs) are rare de novo myeloid neoplasms that exhibit hybrid dysplastic and proliferative features at presentation. This SHP/EAHP Workshop session was uniquely problematic owing to the overlap between MDS/MPNs and both chronic myeloproliferative neoplasms and myelodysplasia.
openaire +2 more sources
Molecular approach to diagnose BCR/ABL negative chronic myeloproliferative neoplasms
Chronic myeloproliferative neoplasms arise from clonal proliferation of hematopoietic stem cells. According to the World Health Organization myeloproliferative neoplasms are classified as: chronic myelogenous leukemia, polycythemia vera, essential ...
Michelle Maccarini Barcelos +1 more
doaj +1 more source
Elevated Vitamin B12 Levels in Myeloproliferative Neoplasm (MPN) Patients: A Potential Diagnostic and Prognostic Marker. [PDF]
Abdalla Fadul,1 Elmustafa Abdalla,1 Anas Mohamed,1 Bashir Ali,1 Nusiba Elamin,1 Ahmed Abdelghafar Alsayed,1 Abdulrahman F Al-Mashdali,2 Kalpana Singh,3 Shehab F Mohamed2 1Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar ...
Fadul A +8 more
europepmc +2 more sources
Transduction-Transplantation Mouse Model of Myeloproliferative Neoplasm. [PDF]
Transduction-transplantation is a quick and efficient way to model human hematologic malignancies in mice. This technique results in expression of the gene of interest in hematopoietic cells and can be used to study the gene's role in normal and/or ...
Morse, Sarah J +2 more
core +1 more source
Breakthroughs in myeloproliferative neoplasms
The discovery of the JAK2V617F mutation ushered the field of Philadelphia-negative myeloproliferative neoplasms (MPNs) into the era of targeted therapy. Currently, there are several JAK2 inhibitors in clinical trials for patients with MPNs, particularly for patients with myelofibrosis (MF).
Fabio P S, Santos, Srdan, Verstovsek
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Background Chronic myeloid leukemia (CML) and chronic neutrophilic leukemia (CNL) are two myeloproliferative neoplasms with mutually exclusive diagnostic criteria.
Sarah A. Carratt +4 more
doaj +1 more source
The personal impact of living with a Myeloproliferative Neoplasm (MPN).
The aim of the current study is to gain insight into the psycho-social effects of having a Myeloproliferative Neoplasm (MPN), a rare type of cancer. The impact of the disease on quality of life will be investigated, both physically, psychologically and ...
Marjan Nijkamp +4 more
core +1 more source
Genetics of Myeloproliferative Neoplasms [PDF]
In the last decade, genomic studies have identified multiple recurrent somatic mutations in myeloproliferative neoplasms (MPNs). Beginning with the discovery of the JAK2 V617F mutation, multiple additional mutations have been found that constitutively activate cell-signaling pathways, including MPL, CBL, and LNK.
Aaron D, Viny, Ross L, Levine
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Numerous studies have documented ultrastructural abnormalities in malignant megakaryocytes from bone marrow (BM) of myelofibrosis patients but the morphology of these cells in spleen, an important extramedullary site in this disease, was not investigated
Maria Zingariello +8 more
doaj +1 more source
. A middle-aged man was diagnosed with myelodysplastic/myeloproliferative neoplasm-unclassifiable (MDS/MPN-U), with severe and extensive corticosteroid-resistant Sweet’s syndrome (SS) as the first manifestation, with evidence of clinical manifestations ...
Chuanli Zhao +9 more
core +1 more source

