Results 31 to 40 of about 35,561 (168)

JAK2 rs10974944 is associated with both V617F‐positive and negative myeloproliferative neoplasms in a Vietnamese population: A potential genetic marker

Molecular Genetics & Genomic Medicine, 2022
The JAK2 gene encodes for a non‐receptor tyrosine kinase that plays a key role in the JAK/STAT signaling transfer pathway. Genetic polymorphisms of this gene have been indicated to be associated with myeloproliferative neoplasm‐associated thrombosis in ...
Nguyen Thy Ngoc, Bui Bich Hau, Nguyen Ba Vuong, Nguyen Thi Xuan   +3 more
doaj   +1 more source

Autoimmunity and the risk of myeloproliferative neoplasms

Haematologica, 2010
The causes of myeloproliferative neoplasm (MPN) are unknown. We conducted a large population-based study including 11,039 myeloproliferative neoplasm patients and 43,550 matched controls with the aim of assessing the associations between a personal ...
Sigurdur Y. Kristinsson, Ola Landgren, Jan Samuelsson, Magnus Björkholm, Lynn R. Goldin   +4 more
doaj   +1 more source

The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells. [PDF]

, 2020
Background:Evasion from programmed cell death is a hallmark of cancer and can be achieved in cancer cells by overexpression of inhibitor of apoptosis proteins (IAPs).
Craver, Brianna M, Fleischman, Angela G, Huynh, Christy, Morse, Sarah J, Nguyen, Hellen, Nguyen, Jenny, Nguyen, Thanh Kim   +6 more
core  

Erythematous Macular Eruption in an Older Woman [PDF]

, 2019
A white woman in her 70s with advanced Alzheimer disease was referred to the hematology clinic for evaluation of a high hemoglobin level (169 g/L; normal range, 120-160 g/L) and red blood cell count (5.67 × 1012/L; normal range, 3.8-4.8 × 1012/L) as well
Kernohan, Neil, McLaughlin, David, Tauro, Sudhir   +2 more
core   +2 more sources

Molecular approach to diagnose BCR/ABL negative chronic myeloproliferative neoplasms

Revista Brasileira de Hematologia e Hemoterapia, 2011
Chronic myeloproliferative neoplasms arise from clonal proliferation of hematopoietic stem cells. According to the World Health Organization myeloproliferative neoplasms are classified as: chronic myelogenous leukemia, polycythemia vera, essential ...
Michelle Maccarini Barcelos, Maria Cláudia Santos-Silva   +1 more
doaj   +1 more source

Neutrophilic Dermatosis of the Dorsal Hands Associated with a “Myeloproliferative Neoplasm, Unclassifiable“ and a Simultaneous Cancer of Colon

Acta Medica, 2010
Neutrophilic dermatosis of the dorsal hands is a variant of Sweet's syndrome. We herein describe an 83-year old woman with a neutrophilic dermatosis of the dorsal hands associated with a "myeloproliferative neoplasm, unclassifiable" and a simultaneous ...
Francisco José Fernández-Fernández, Juan Carlos Álvarez – Fernández, Esperanza Romero – Picos, Juan Antonio Garrido, Pascual Sesma   +4 more
doaj   +1 more source

Outgrowth of a CSF3R-mutant clone drives a second myeloproliferative neoplasm in a chronic myeloid leukemia patient: a case report

Biomarker Research, 2021
Background Chronic myeloid leukemia (CML) and chronic neutrophilic leukemia (CNL) are two myeloproliferative neoplasms with mutually exclusive diagnostic criteria.
Sarah A. Carratt, Diana Brewer, Julia E. Maxson, Brian J. Druker, Theodore P. Braun   +4 more
doaj   +1 more source

STAT1 activation in association with JAK2 exon 12 mutations [PDF]

, 2015
La inclusión de la perspectiva de género en la actividad jurisdiccional es una demanda sostenida de los colectivos feministas y de mujeres, dado que las sentencias tienen un poder performativo y envían un mensaje a la sociedad: “[…] tienen un poder ...
Godfrey, A.L., Chen, E., Massie, C.E., Silber, Y., Pagano, F., Bellosillo, B., Guglielmelli, P., Harrison, C.N., Reilly, J.T., Stegelmann, F., Bijou, F., Lippert, E., Boiron, J.M., Dohner, K., Vannucchi, A.M., Besses, C., Green, A.R., Godfrey, A.L., Chen, E., Massie, C.E., Silber, Y., Pagano, F., Bellosillo, B., Guglielmelli, P., Harrison, C.N., Reilly, J.T., Stegelmann, F., Bijou, F., Lippert, E., Boiron, J.M., Dohner, K., Vannucchi, A.M., Besses, C., Green, A.R.   +33 more
core   +4 more sources

Shared and Distinctive Ultrastructural Abnormalities Expressed by Megakaryocytes in Bone Marrow and Spleen From Patients With Myelofibrosis

Frontiers in Oncology, 2020
Numerous studies have documented ultrastructural abnormalities in malignant megakaryocytes from bone marrow (BM) of myelofibrosis patients but the morphology of these cells in spleen, an important extramedullary site in this disease, was not investigated
Maria Zingariello, Vittorio Rosti, Alessandro M. Vannucchi, Paola Guglielmelli, Maria Mazzarini, Giovanni Barosi, Maria Luisa Genova, Anna Rita Migliaccio, Anna Rita Migliaccio   +8 more
doaj   +1 more source

Mouse models of myeloproliferative Neoplasms: JAK of all grades. (Review) [PDF]

, 2011
In 2005, several groups identified a single gain-of-function point mutation in the JAK2 kinase that was present in the majority of patients with myeloproliferative neoplasms (MPNs).
Li, J., Kent, D.G., Chen, E., Green, A.R., Li, J., Kent, D.G., Chen, E., Green, A.R.   +7 more
core   +2 more sources