Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms. [PDF]
, 2014 Myeloproliferative neoplasms (MPNs) are clonal hematological diseases in which cells of the myelo-erythroid lineage are overproduced and patients are predisposed to leukemic transformation.
de Haan, Gerald +3 more
core +1 more source
Aortic thrombus in a patient with myeloproliferative thrombocytosis, successfully treated by pharmaceutical therapy: a case report [PDF]
, 2010 Introduction Thrombosis in myeloproliferative thrombocytosis occurs usually in the microvessels and medium-sized arteries and veins and only rarely in the aorta. Aortic thrombosis is usually treated with thrombectomy.
Hidesuke Yamamoto +4 more
core +2 more sources
Case Report: Free-Floating Intracoronary Thrombus: Who Is the Convict?
Frontiers in Oncology, 2022 In young patients, especially with no traditional coronary risk factors, hypercoagulable states may always be considered as an alternative cause of acute coronary syndromes.
Francesca Mantovani +3 more
doaj +1 more source
Development of a highly sensitive method for detection of JAK2V617F [PDF]
, 2011 Background Ph- myeloproliferative neoplasms (MPNs) represent a heterogeneous group of chronic diseases characterized by increased expansion of hematopoietic cells of the myeloid lineage.
Anna H Zhao, Rufei Gao, Zhizhuang J Zhao
core +1 more source
Hydroxyurea-Induced Pneumopathy in a Patient With Myeloproliferative Syndrome
Clinical Medicine Insights: Case Reports, 2018 Hydroxyurea (HU) is a drug frequently used in the treatment of chronic myeloproliferative neoplasms. The most common side effects of this drug are pancytopenia, digestive and skin disorders.
Oriol Plans Galván +5 more
doaj +1 more source
Myeloproliferative neoplasms: a review of diagnostic criteria and clinical aspects [PDF]
, 2010 Chronic myeloproliferative disorders, currently called myeloproliferative neoplasms (MPN), according to the 4th edition of the World Health Organization (WHO) classification are clonal diseases of hematopoietic stem cells, in which there is increased ...
Chauffaille, Maria de Lourdes Lopes Ferrari
core +1 more source
Single-cell analysis based dissection of clonality in myelofibrosis
Nature Communications, 2020 Myelofibrosis is a myeloproliferative neoplasm. Here, the authors show the clonal evolution of myelofibrosis during JAK inhibitor therapy, revealing how the treatment results in an increase in clonal complexity and a gain of RAS pathway mutations.
Elena Mylonas +21 more
doaj +1 more source
Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation
Hematology, Transfusion and Cell Therapy, 2018 Background: Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms.
Maira da Costa Cacemiro +11 more
doaj +1 more source
Acute liver failure precipitated by acute Budd‐Chiari syndrome and complete portal vein thrombosis
Clinical Case Reports, 2021 Acute Budd‐Chiari syndrome and complete portal vein thrombosis are important features of myeloproliferative neoplasm that may occur simultaneously, resulting in acute liver failure.
Yuji Suzuki +3 more
doaj +1 more source
Idiopathic noncirrhotic portal hypertension: current perspectives [PDF]
, 2016 The term idiopathic noncirrhotic portal hypertension (INCPH) has been recently proposed to replace terms, such as hepatoportal sclerosis, idiopathic portal hypertension, incomplete septal cirrhosis, and nodular regenerative hyperplasia, used to describe ...
D'AMATI, Giulia +5 more
core +1 more source