Results 71 to 80 of about 30,070 (260)

Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation

Hematology, Transfusion and Cell Therapy, 2018
Background: Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms.
Maira da Costa Cacemiro, Juçara Gastaldi Cominal, Raquel Tognon, Natalia de Souza Nunes, Belinda Pinto Simões, Lorena Lôbo de Figueiredo-Pontes, Luiz Fernando Bazzo Catto, Fabíola Traina, Elizabeth Xisto Souto, Fabiana Albani Zambuzi, Fabiani Gai Frantz, Fabíola Attié de Castro   +11 more
doaj   +1 more source

Acute liver failure precipitated by acute Budd‐Chiari syndrome and complete portal vein thrombosis

Clinical Case Reports, 2021
Acute Budd‐Chiari syndrome and complete portal vein thrombosis are important features of myeloproliferative neoplasm that may occur simultaneously, resulting in acute liver failure.
Yuji Suzuki, Akiko Suzuki, Keisuke Kakisaka, Yasuhiro Takikawa   +3 more
doaj   +1 more source

Rare gene fusion rearrangement SPTNB1-PDGFRB in an atypical myeloproliferative neoplasm

, 2018
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia recognizes a distinct class of myeloid and lymphoid tumors with eosinophilia-related proliferations associated with specific gene rearrangements ...
Venu Bathini, William Walsh, Neeraj Y. Saini, Vanessa Fiorini Furtado, Patricia M. Miron   +4 more
core   +2 more sources

Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype in JAK2-mutated myeloproliferative neoplasms

Haematologica, 2017
High mobility group AT-hook 2 (HMGA2) is an architectural transcription factor that is negatively regulated by let-7 microRNA through binding to it’s 3′-untranslated region. Transgenic mice expressing Hmga2 with a truncation of its 3′-untranslated region
Chih-Cheng Chen, Jie-Yu You, Jrhau Lung, Cih-En Huang, Yi-Yang Chen, Yu-Wei Leu, Hsing-Ying Ho, Chian-Pei Li, Chang-Hsien Lu, Kuan-Der Lee, Chia-Chen Hsu, Jyh-Pyng Gau   +11 more
doaj   +1 more source

Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis

, 2017
We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia ...
Zhen Song, Zefeng Xu, Tiejun Qin, Zhijian Xiao, Robert Peter Gale, Jinqin Liu, Gang Huang, Bing Li, Jie Bai, Peihong Zhang, Lei Zhang, Yue Zhang   +11 more
core   +1 more source

Survival of patients with chronic myeloproliferative neoplasms and new primary cancers:a population-based cohort study [PDF]

, 2015
Background: Patients with chronic myeloproliferative neoplasms are at increased risk of new solid or haematological cancers, but how prognosis is affected in patients with preceding myeloproliferative neoplasms is unclear.
Hasselbalch, Hans Carl, Stentoft, Jesper, Christiansen, Christian Fynbo, Toft Sørensen, Henrik, Farkas, Dóra Körmendiné, Larsen, Thomas Stauffer, Frederiksen, Henrik   +6 more
core   +1 more source

Thrombocytosis and the generation of platelet‐derived microparticles in the pathophysiology of sickle cell disease

British Journal of Haematology, EarlyView.
Thrombocytosis is associated with an increased production of platelet‐derived microparticles from activated platelets, which contribute to vaso‐occlusion in sickle cell disease by perpetuating the cycle of inflammation, procoagulant state and endothelial dysfunction.
Giao N. Lê, Anna Dillon, Owen P. Smith, Corrina McMahon   +3 more
wiley   +1 more source

Arterial and Venous Thrombosis in Patients with Myeloproliferative Neoplasms

Jurnal Penyakit Dalam Indonesia, 2019
Introduction. Myeloproliferative neoplasm (MPN) is a hematologic disorder that consists of polycythemia vera (PV), essential thrombocythemia (ET and primary myelofibrosis (PMF) and complication of thrombosis is frequently found in patients with MPN. This
Lugyanti Sukrisman
doaj   +1 more source

A case of MDS/MPN overlap syndrome with ring sideroblasts and thrombocytosis: Tackling the quandary of thrombosis versus hemorrhage

Clinical Case Reports, 2023
Key Clinical Message No formal treatment guidelines for MDS/MPN‐RS‐T exist. With salient features such as anemia and thrombocytosis, management is individualized and aims to address anemia, thrombosis, and in some cases acquired von Willebrand's disease.
Hannah Cherniawsky, Habib Moshref Razavi
doaj   +1 more source

Somatic mutations of calreticulin in myeloproliferative neoplasms and myelodysplastic/myeloproliferative neoplasms

Haematologica, 2014
According to the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues, myeloproliferative neoplasms (MPN) include chronic myeloid leukemia and the so-called Philadelphia-negative myeloproliferative neoplasms, i.e.
MALCOVATI, LUCA, RUMI, ELISA, CAZZOLA, MARIO   +2 more
openaire   +4 more sources