Results 81 to 90 of about 35,561 (168)

Can somatic GATA2 mutation mimic germ line GATA2 mutation? [PDF]

, 2018
Somatic GATA2 mutation is associated with immunodeficiency and pulmonary alveolar proteinosis in a patient with myeloproliferative ...
Collin, M, Dickinson, R, Lipman, M, Lowe, D, Marafioti, T, Mitchell, C, Pocock, R, Sekhar, M   +7 more
core  

JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition [PDF]

, 2018
Patients with myeloproliferative neoplasms (MPNs) frequently progress to bone marrow failure or acute myeloid leukemia (AML), and mutations in epigenetic regulators such as the metabolic enzyme isocitrate dehydrogenase (IDH) are associated with poor ...
Alan H. Shih, Allison N. Lau, Amritha Varshini Hanasoge Somasundara, Andrew M. Intlekofer, Anna Sophia McKenney, April Chiu, Barbara Spitzer, Craig B. Thompson, Efthymia Papalexi, Elizaveta Freinkman, Esra A. Akbay, Franck T. Rapaport, Gaujoux, Jihae Ahn, Julie Teruya-Feldstein, Kaitlyn Shank, Katharine Yen, Kwok-Kin Wong, Matthew G. Vander Heiden, Mesa, Minal A. Patel, Mya Steadman, Raajit Rampal, Raj Nagaraja, Ross L. Levine, Stein, Tefferi   +26 more
core   +1 more source

Dysregulation of the intrinsic apoptotic pathway mediates megakaryocytic hyperplasia in myeloproliferative neoplasms [PDF]

, 2016
published_or_final_versio
Erber, WN, Forsyth, C, Fuller, KA, Guo, BB, Howman, R, Ip, HW, Kavanagh, S, Malherbe, JA, Mirzai, B, So, JCC   +9 more
core   +1 more source

Coexistence of chronic lymphocytic leukemia and polycythemia vera: a case report and review of the literature

Annals of Saudi Medicine, 2016
Polycythemia vera is a Philadelphia chromosome-negative myeloproliferative neoplasm. Chronic lymphocytic leukemia is a monoclonal expansion of a CD5+ CD19+ B lymphocytes.
Serdal Korkmaz, Sinan Kulakoglu, Hasan Gorkem, Bilal Aygun, Ali Cetinkaya   +4 more
doaj   +1 more source

Ruxolitinib in the treatment of polycythemia vera: patient selection and special considerations. [PDF]

, 2016
The discovery of JAK2 V617F mutation in the mid-2000s started to fill the gap between clinical presentation of polycythemia vera (PV), first described by Vaquez at the end of the 19th century, and spontaneous erythroid colony formation, reported by ...
Alberio, L., Blum, S., Martins, F.
core   +2 more sources

Genomic profiling for thrombosis risk prediction in myeloproliferative neoplasms

Bleeding, Thrombosis and Vascular Biology
The main BCR-ABL-negative myeloproliferative neoplasms consist of polycythemia vera, essential thrombocythemia and primary myelofibrosis. They have been associated with an overall elevated risk of thromboembolism, including both venous and arterial ...
Simon Mantha
doaj   +1 more source

Chronic myeloproliferative neoplasm in adulthood in CBL syndrome harboring a splice‐site CBL variant alongside a novel constitutional CSF3R variant

eJHaem
Casitas B‐cell lineage (CBL) syndrome is a rare RASopathy known to predispose to CBL‐mutated juvenile myelomonocytic leukemia (JMML) in childhood. Adulthood acute myeloid leukemia arising out of a genetic aberrancies consistent with prior CBL‐mutated ...
George Mason, Rhian Aghajani, Brieanna Dance, Jad Othman, Linda Goodwin, William Stevenson, Naomi Mackinlay   +6 more
doaj   +1 more source

Ponatinib as targeted therapy for FGFR1 fusions associated with the 8p11 myeloproliferative syndrome

Haematologica, 2013
The 8p11 myeloproliferative syndrome is a rare, aggressive myeloproliferative neoplasm characterized by constitutively active FGFR1 fusion proteins that arise from specific chromosomal translocations and which drive aberrant proliferation. Although FGFR1
Andrew Chase, Catherine Bryant, Joannah Score, Nicholas C.P. Cross   +3 more
doaj   +1 more source

Analysis of histological frequency and pediatric cancer in Rondônia, Western Amazonia (Brazil) [PDF]

, 2018
Objective:Describe the histological and cancer frequency in children and adolescents attended at the Hospital de Base Dr. Ary Pinheiro and the Hospital de Barretos / Rondônia, Western Amazonia, in the years 2014 and 2015.
Aguiar, R. R. (Rodrigo), Almeida, F. M. (Fabrício), Paraguassú-Chaves, C. A. (Carlos), Romanholo, R. A. (Rafael), Souza, L. P. (Laurindo)   +4 more
core  

Myelodysplastic/Myeloproliferative Neoplasms with Features Intermediate between Primary Myelofibrosis and Chronic Myelomonocytic Leukemia: Case Series and Review of the Entity

Hemato
Diagnosis of myeloid neoplasm is currently performed according to the presence of a predetermined set of clinical, morphological, and molecular diagnostic criteria agreed upon by a consensus of experts.
Arturo Bonometti, Simone Zanella, Daoud Rahal, Chiara Milanesi, Rossella Caselli, Matteo Giovanni Della Porta, Silvia Uccella, Sara Fraticelli   +7 more
doaj   +1 more source