Results 171 to 180 of about 60,444 (298)

Thorough QT Study on the Effect of Therapeutic and Supratherapeutic Dosing of Givinostat in Healthy Volunteers

Clinical Pharmacology in Drug Development, Volume 15, Issue 3, March 2026.
Abstract Givinostat is a class I/II histone deacetylase inhibitor indicated for Duchenne muscular dystrophy (DMD). The study evaluated the effect of therapeutic and supratherapeutic givinostat doses on the QT/QTc interval. Healthy volunteers received each treatment—givinostat hydrochloride monohydrate oral suspension as a therapeutic (100 mg) or ...
Eugenio Mercuri, Barry Byrne, Tracey Willis, John Bourke, Paolo Bettica, Sara Cazzaniga, Hongqi Xue, Borje Darpo   +7 more
wiley   +1 more source

Health Benefits of Polysaccharides in Red Algae: A Comprehensive Review

Food Frontiers, Volume 7, Issue 2, March 2026.
Graphical abstract showing the health benefits of red algal polysaccharides. ABSTRACT Humans have long consumed red algae (especially by the Asian community), and their polysaccharide extracts (carrageenan, agar) are extensively used in the food industry as gel thickeners.
Sammueal Jun Kai Ong, Matthew Myint, Sean Chia, Chee Fan Tan, Yi Fan Hong, Meiyappan Lakshmanan, Ying Swan Ho, Thomas T. Wheeler, Xuezhi Bi, Ian Walsh, Kuin Tian Pang   +10 more
wiley   +1 more source

Evaluating the Feasibility and Safety of Daily Inter-facility Travel for Proton Beam Therapy During Chemotherapy-Induced Myelosuppression in Children With Cancer. [PDF]

Cureus
Furui Y, Araya M, Masaki H, Mizushiro N, Koiwai K, Uchida E, Morokawa H, Okura E, Komori K, Morita D, Kurata T, Hirabayashi K, Saito S, Tanaka M, Nakazawa Y, Sakashita K.   +15 more
europepmc   +1 more source

Severe Myelosuppression [PDF]

, 2020
openaire   +1 more source

Unraveling the role of TP53 mutations in myeloproliferative neoplasms: Molecular mechanisms of leukemic transformation

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract TP53 mutations are found in over 50% of tumor types, including myeloproliferative neoplasms (MPNs). MPNs are characterized by a chronic phase, which may progress to secondary acute myeloid leukemia (sAML). Here, we discuss the physiological functions of p53 in hematopoiesis and its deregulation in MPNs.
Suzana da Silva‐Benedito, Paula Sabbo Bernardo, Jean‐Edouard Martin, Caroline Marty, Isabelle Plo, Iléana Antony‐Debré, Bárbara da Costa Reis Monte‐Mór   +6 more
wiley   +1 more source

Exploration of the Active Component and Mechanisms of Shengyu Decoction Against Myelosuppression Using Network Pharmacology and in vitro Experimental Validation

Drug Design, Development and Therapy
Bingjie Ma,1 Pengyi Hou,2 Ran Liu,3 Aijun Cang,1 Limei Zhao4 1Department of Pharmacy, People’s Hospital of Liaoning Province, Shenyang, 110010, People’s Republic of China; 2SCIEX Analytical Instrument Trading Co, Shanghai, 200000, People’s Republic of ...
Ma B, Hou P, Liu R, Cang A, Zhao L
doaj  

NCOA2 promotes the return of hematopoietic stem cells to quiescence after irradiation stress by regulating FOXO3a‐dependent mitophagy

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract Hematopoietic stem cells (HSCs) are responsible for replenishing blood cells under stress conditions through increasing proliferation and differentiation. After the hematopoietic function has reconstructed, HSCs must re‐enter a quiescent state to avoid their depletion, whereas the underlying mechanisms remain to be elucidated.
Fang Chen, Naicheng Chen, Linjie Wang, Hao Zeng, Yukai Lu, Yanying Liu, Jing Chen, Yang Xu, Mo Chen, Song Wang, Mingqiang Shen, Junping Wang, Mengjia Hu   +12 more
wiley   +1 more source

Cytopenias With HIV in the Era of Highly Active Antiretroviral Therapy: Are We Winning the Battle?

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aim Cytopenias remain among the most frequent hematologic complications of HIV infection, affecting treatment outcomes and quality of life. The introduction of highly active antiretroviral therapy has markedly reduced their incidence by restoring immune function and suppressing viral replication.
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Plasma glutamic acid predicts myelosuppression and mortality in septic patients using machine learning. [PDF]

Sci Rep
Nunnari A, Mearelli F, Spagnol F, Di Girolamo FG, Fiotti N, Pognuz ER, Zerbato V, Di Bella S, Biolo G.   +8 more
europepmc   +1 more source

Myelosuppressive Therapy [PDF]

, 2020
openaire   +1 more source