Results 201 to 210 of about 60,444 (298)

Remodeling the Inflammatory Microenvironment: Nanomaterial‐Based Targeted Strategies for Systemic Lupus Erythematosus and Lupus Nephritis

open access: yesSmall Science, Volume 6, Issue 3, March 2026.
Current treatments for severe lupus nephritis are limited by side effects due to poor drug targeting. This review explores how smart nanomaterials—like liposomes and biomimetic carriers—can precisely deliver drugs to overactive immune cells and the kidneys. These nanotherapeutics enhance efficacy, reduce toxicity, and enable combination strategies. The
Cheng Zhou   +6 more
wiley   +1 more source

A Core Outcome Set to Guide Future Research on Caesarean Scar Ectopic Pregnancy: COSCAR Consensus Study

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 4, Page 725-738, March 2026.
ABSTRACT Objective To develop a core outcome set (COS) for research on caesarean scar ectopic pregnancy (CSEP) treatment. Design Consensus development study. Setting International. Population Healthcare professionals, researchers, patient advocates, or individuals with lived experience of CSEP.
Simrit Nijjar   +11 more
wiley   +1 more source

Bridging FDA Adverse Event Reporting System (FAERS) and Clinical Practice: Comprehensive Characterization of Immune Checkpoint Inhibitors Toxicities in Geriatric Lung Cancer Patients

open access: yesThoracic Cancer, Volume 17, Issue 6, March 2026.
Elderly lung cancer patients face increased risks of severe and fatal AEs during ICIs treatment. Reports concerning males, Asians, and anti‐PD‐1 recipients were associated with higher odds of a fatal outcome. Immune‐mediated pneumonitis is the most frequently reported severe AE, calling for heightened vigilance for these high‐risk subgroups.
Yumeng Tian   +5 more
wiley   +1 more source

Managing the Complex Intersection Between Substance Use Disorders and Infectious Diseases

open access: yes
JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 3, March 2026.
Karissa Chow   +4 more
wiley   +1 more source

Targeting MCL‐1 and MAPK overcomes venetoclax resistance in FLT3‐ITD‐positive AML cells harbouring activating PTPN11 (SHP‐2) mutations

open access: yesBritish Journal of Haematology, Volume 208, Issue 3, Page 905-915, March 2026.
Summary Venetoclax (VEN)‐based therapies have improved the treatment of acute myeloid leukaemia (AML); however, the emergence of resistance remains a major limitation. Mutations in protein tyrosine phosphatase (PTP) non‐receptor type 11 (PTPN11) and FMS like tyrosine kinase 3 with internal tandem duplication (FLT3‐ITD) are common in resistant patients ...
Maximilian Fleischmann   +12 more
wiley   +1 more source

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