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Cytomegalovirus mediated myelosuppression
Journal of Clinical Virology, 2002Cytomegalovirus (CMV) has long been associated with myelosuppression. Evidence for this association has been provided from in vitro studies, statistical analysis of clinical studies, informative case reports, and murine models. Reports differ as to how CMV mediates myelosuppression.
Beverly Torok-Storb +2 more
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Nutrients, 2022 Myelosuppression is a common and intractable side effect of cancer therapies including radiotherapy and chemotherapy, while the underlying mechanism remains incompletely understood.
Changhong Du +2 more
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Pharmacogenomics, 2010 Thiopurine S-methyltransferase (TPMT) metabolizes thiopurine medications, including azathioprine and 6-mercaptopurine. Absent TPMT activity (i.e., in individuals homozygous for a variant TPMT allele) is associated with an increased risk of ...
Katherine Payne +2 more
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Mechanistic Models for Myelosuppression
Investigational New Drugs, 2003As myelosuppression is the dose-limiting toxicity for most chemotherapeutic drugs, modelers attempt to find relationships between drug and toxicity to optimize treatment. Mechanistic models, i.e. models based on physiology and pharmacology, are preferable over empirical models, as prior information can be utilized and as they generally are more ...
Lena E, Friberg, Mats O, Karlsson
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Chemotherapy-induced myelosuppression
Seminars in Oncology Nursing, 1992Chemotherapy-induced myelosuppression is the most common dose-limiting and potentially fatal complication of cancer treatment. Prior attempts to lessen chemotherapy-induced myelosuppression have been minimally effective. The new hematopoietic growth factors show promise, especially for patients requiring intensely myelotoxic chemotherapy.
M B, Maxwell, K E, Maher
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Myelosuppression in Legionnaires' Disease
Archives of Internal Medicine, 1982• A patient undergoing examination for moderately severe renal insufficiency had fulminant five-lobed pneumonia caused by Legionella pneumophila . Her clinical course was complicated by granulocytopenia. Bone marrow aspiration showed notable inhibition of myelopoiesis, involving all stages of maturation.
B E, Johnson, S R, Lynch, C H, Park
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Blood support for the myelosuppressed patient
Seminars in Oncology Nursing, 1990O NE OF THE MOST important advances in cancer treatment has been the improved production and use of blood component therapy for the patient with life-threatening myelosuppression. Critical episodes of anemia and bleeding as a result of cancer and/or cancer treatment can be prevented and managed with a refined system of blood banking and transfusion ...
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