Results 1 to 10 of about 41,531 (223)

Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis

EBioMedicine, 2015
Long-term linezolid use is limited by mitochondrial toxicity-associated adverse events (AEs). Within a prospective, randomized controlled trial of linezolid to treat chronic extensively drug-resistant tuberculosis, we serially monitored the translational
Yumi Park, Véronique Dartois, Laura E Via   +2 more
exaly   +3 more sources

Evaluation of the impact of rifampicin on the plasma concentration of linezolid in tuberculosis co-infected patients

Frontiers in Pharmacology, 2023
Linezolid combined with rifampicin has shown excellent clinical outcomes against infection by multi-resistant Gram-positive bacteria. However, several studies have indicated that rifampicin reduces the plasma concentration of linezolid in patients with ...
Pan Yan, Qun-Zhi Shi, Yi-Xing Hu, Ying Zeng, Hong Lu   +4 more
doaj   +1 more source

Parallel evolution of linezolid-resistant Staphylococcus aureus in patients with cystic fibrosis

Microbiology Spectrum, 2023
Linezolid is an antibiotic used to treat serious Staphylococcus aureus infections. Resistance to linezolid is considered rare but could emerge with repeated dosing.
Nicholas J. Pitcher, Andries Feder, Nicholas Bolden, Christian F. Zirbes, Anthony J. Pamatmat, Linda Boyken, Jared J. Hill, Alyssa R. Bartels, Andrew L. Thurman, Valerie C. Reeb, Harry S. Porterfield, Ahmed M. Moustafa, Paul J. Planet, Anthony J. Fischer   +13 more
doaj   +1 more source

Phenotypic and genotypic characterisation of linezolid-resistant coagulase-negative staphylococci possessing cfr-carrying plasmid

Journal of Global Antimicrobial Resistance, 2022
: Objectives: Linezolid-dependent growth has contributed to wide dissemination of Staphylococcus epidermidis in hospitals. This study aimed to characterise linezolid-resistant coagulase-negative staphylococci (CoNS) isolates and the possibility of ...
Fei Jiang, Ziyan Kong, Ke Liu, Chen Cheng, Tingting Jiang, Ping Ma, Rongpeng Li   +6 more
doaj   +1 more source

Linezolid for the Treatment of Urinary Tract Infections Caused by Vancomycin-Resistant Enterococci

Pharmacy, 2021
Vancomycin-resistant enterococci (VRE) account for a large proportion of hospital-acquired infections. Determining optimal treatment of VRE urinary tract infections (UTIs) is challenging.
Mary Joyce Wingler, Neel R. Patel, S. Travis King, Jamie L. Wagner, Katie E. Barber, Kayla R. Stover   +5 more
doaj   +1 more source

Successful treatment of linezolid-induced severe lactic acidosis with continuous venovenous hemodiafiltration: A case report

Saudi Pharmaceutical Journal, 2022
Linezolid is an oxazolidinone antibiotic. Linezolid-associated lactic acidosis has been reported in 6.8% of linezolid-treated patients. Lactic acidosis is associated with poor clinical outcomes, with high blood lactate levels resulting in organ ...
Naiju Zhang, Fan Zhang, Zhong Chen, Rui Huang, Juan Xia, Jinchun Liu   +5 more
doaj   +1 more source

Linezolid-associated neurologic toxicity in patients with drug-resistant tuberculosis in a bedaquiline-based regimen: A scoping review

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2023
Bedaquiline and linezolid have shown a high efficacy in treating drug-resistant tuberculosis (DR-TB). Neurologic toxicity is the primary adverse effect of linezolid, leading to dose reduction or early discontinuation.
Oki Nugraha Putra, Ronald Pratama Adiwinoto   +1 more
doaj   +1 more source

Different intra-cerebrospinal distribution of linezolid in patients with inflammatory meningitis

International Journal of Infectious Diseases, 2021
Linezolid has excellent antibiotic activity against gram-positive organisms and is expected to be an alternative to vancomycin for the treatment of bacterial meningitis.
Naoki Ichinose, Gakushi Yoshikawa, Eri Fukao, Mai Ichisawa, Tomoaki Takahata, Yuki Enoki, Kazuaki Taguchi, Toshimi Oda, Kazuo Tsutsumi, Kazuaki Matsumoto   +9 more
doaj   +1 more source

Evaluation of Sensitivity and Resistance of Linezolid in Pre Extensively Drug Resistance Tuberculosis and Extensively Drug Resistance Tuberculosis at a Tertiary Care Hospital, Jamnagar, Gujarat, India [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: The diseases have a high prevalence in India, accounting for one fourth of the Tuberculosis (TB) cases in the world. The situation becomes more complicated due to the rising of Human Immunodeficiency virus/AIDS pandemic, the emergence of ...
Dipali Maganbhai Gavali, Binita Aring, Summiya Mullan, Akhlakahemad A Nathametha, Abhishek B Dave   +4 more
doaj   +1 more source

Linezolid use in German acute care hospitals: results from two consecutive national point prevalence surveys

Antimicrobial Resistance and Infection Control, 2019
Background Linezolid belongs to a reserve group of antibiotics. In recent years, reports on linezolid resistance in gram-positive cocci have become more frequent. Overuse of linezolid is a relevant factor for resistance development. The objective of this
Tobias Siegfried Kramer, Frank Schwab, Michael Behnke, Sonja Hansen, Petra Gastmeier, Seven Johannes Sam Aghdassi   +5 more
doaj   +1 more source