In vitro and in vivo synergistic effects of cyclizine and piroxicam in combination with linezolid against methicillin-resistant Staphylococcus aureus [PDF]
Applied Microbiology and BiotechnologyBackground Linezolid (LNZ) is considered one of the last-resort antimicrobial agents reserved for treating methicillin resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA).
Mai A. Moawad +2 more
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Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy. [PDF]
PLoS ONE, 2013 Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid
Josep M Sierra +6 more
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Protective effects of adenosine triphosphate, thiamin, thiamin pyrophosphate, and their combination against linezolid-induced renal injury and lactic acidosis in rats [PDF]
Renal FailureLinezolid, an oxazolidinone antibiotic effective against Gram-positive pathogens, may cause nephrotoxicity and lactic acidosis during prolonged therapy. This experimental study investigated the protective effects of adenosine triphosphate (ATP), thiamin,
Ozlem Admis +7 more
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The effect of fentanyl combined with linezolid on in-hospital mortality in mechanically ventilated patients: A retrospective cohort study. [PDF]
PLoS ONEBackgroundThe combination of linezolid and opioid drugs such as fentanyl may increase the risk of serotonin syndrome, but its impact on in-hospital mortality is not yet clear.
Jia-Hui Niu +4 more
doaj +2 more sources
A Comparative Evaluation of the Therapeutic Effects of Adenosine Triphosphate, Coenzyme Q10, Pyridoxine, and Thiamine Pyrophosphate in a Linezolid-Induced Peripheral Neuropathic Pain Model in Rats [PDF]
PharmaceuticalsBackground/Objectives: Linezolid is an oxazolidinone antibiotic whose prolonged use is associated with peripheral neuropathy, hyperlactatemia, and metabolic acidosis.
Habip Burak Ozgodek +7 more
doaj +2 more sources
Frontiers in Pharmacology, 2023 Linezolid combined with rifampicin has shown excellent clinical outcomes against infection by multi-resistant Gram-positive bacteria. However, several studies have indicated that rifampicin reduces the plasma concentration of linezolid in patients with ...
Pan Yan +4 more
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Parallel evolution of linezolid-resistant Staphylococcus aureus in patients with cystic fibrosis
Microbiology Spectrum, 2023 Linezolid is an antibiotic used to treat serious Staphylococcus aureus infections. Resistance to linezolid is considered rare but could emerge with repeated dosing.
Nicholas J. Pitcher +13 more
doaj +1 more source
Journal of Global Antimicrobial Resistance, 2022 : Objectives: Linezolid-dependent growth has contributed to wide dissemination of Staphylococcus epidermidis in hospitals. This study aimed to characterise linezolid-resistant coagulase-negative staphylococci (CoNS) isolates and the possibility of ...
Fei Jiang +6 more
doaj +1 more source
Linezolid for the Treatment of Urinary Tract Infections Caused by Vancomycin-Resistant Enterococci
Pharmacy, 2021 Vancomycin-resistant enterococci (VRE) account for a large proportion of hospital-acquired infections. Determining optimal treatment of VRE urinary tract infections (UTIs) is challenging.
Mary Joyce Wingler +5 more
doaj +1 more source
Saudi Pharmaceutical Journal, 2022 Linezolid is an oxazolidinone antibiotic. Linezolid-associated lactic acidosis has been reported in 6.8% of linezolid-treated patients. Lactic acidosis is associated with poor clinical outcomes, with high blood lactate levels resulting in organ ...
Naiju Zhang +5 more
doaj +1 more source