Results 11 to 20 of about 41,531 (223)

Contezolid in the Treatment of Multidrug-Resistant Tuberculous Meningitis: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Multidrug‐resistant tuberculous meningitis (MDR‐TBM) has a high mortality rate, and treatment options are limited. Linezolid is recommended for refractory cases but often causes intolerable adverse reactions such as peripheral neuropathy. Contezolid, a novel oxazolidinone, has shown better safety profiles in preclinical and early clinical ...
Wang N, Li X, Yan Q, Su H, Liu Y, Li Y, Yang C, Gu Y, Yan T, Wang Q, Liu X.   +10 more
europepmc   +2 more sources

Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.

PLoS ONE, 2013
Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid
Josep M Sierra, Mariana Camoez, Fe Tubau, Oriol Gasch, Miquel Pujol, Rogelio Martin, M Angeles Domínguez   +6 more
doaj   +3 more sources

The Effectiveness of Linezolid and Teicoplanin for Managing Infections After Burn Injuries: A Retrospective Study. [PDF]

Health Sci Rep
ABSTRACT Background and Aims Gram‐positive infections in burn patients present significant treatment challenges. This study compared the efficacy and safety of linezolid vs. teicoplanin for managing such infections in a clinical setting. Methods We conducted a retrospective study involving 77 burn patients with confirmed Gram‐positive infections at ...
Zendehdel A, Roham M, Soltani S, Jahanshahi A, Heidarizadi S.   +4 more
europepmc   +2 more sources

In vitro and in vivo synergistic effects of cyclizine and piroxicam in combination with linezolid against methicillin-resistant Staphylococcus aureus [PDF]

Applied Microbiology and Biotechnology
Background Linezolid (LNZ) is considered one of the last-resort antimicrobial agents reserved for treating methicillin resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA).
Mai A. Moawad, Abeer M. Abd El-Aziz, Mona I. Shaaban   +2 more
doaj   +2 more sources

Effect of Platelet Parameters on Linezolid-Related Thrombocytopenia in Hospitalized Patients

Infection and Drug Resistance, 2023
Lu Zhang, Yan Yan, Ru Liao, Haiyan Dong Department of Pharmacy, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaCorrespondence: Haiyan Dong, Department of Pharmacy, the First Affiliated Hospital of Xi ...
Zhang L, Yan Y, Liao R, Dong H
doaj   +1 more source

Evaluation of the stability of linezolid in aqueous solution and commonly used intravenous fluids [PDF]

Drug Design, Development and Therapy, 2017
Rachel Taylor, Bruce Sunderland, Giuseppe Luna, Petra Czarniak School of Pharmacy, Faculty of Health Sciences, Curtin University, Bentley, WA, Australia Purpose: The aim was to evaluate the stability of linezolid in commonly used intravenous fluids and
Taylor R, Sunderland B, Luna G, Czarniak P   +3 more
doaj   +2 more sources

Linezolid Dependence in Staphylococcus epidermidis Bloodstream Isolates

Emerging Infectious Diseases, 2013
We document linezolid dependence among 5 highly linezolid-resistant (LRSE) Staphylococcus epidermidis bloodstream isolates that grew substantially faster at 32 µg/mL linezolid presence.
Spyros Pournaras, Eleni Ntokou, Olympia Zarkotou, Kyriaki Ranellou, Katerina Themeli-Digalaki, Constantinos Stathopoulos, Athanassios Tsakris   +6 more
doaj   +2 more sources

Radezolid Is More Effective Than Linezolid Against Planktonic Cells and Inhibits Enterococcus faecalis Biofilm Formation

Frontiers in Microbiology, 2020
The aim of this study was to compare the effects of radezolid and linezolid on planktonic and biofilm cells of Enterococcus faecalis. A total of 302 E.
Jinxin Zheng, Jinxin Zheng, Zhong Chen, Zhong Chen, Zhiwei Lin, Xiang Sun, Xiang Sun, Bing Bai, Guangjian Xu, Guangjian Xu, Junwen Chen, Zhijian Yu, Di Qu   +12 more
doaj   +1 more source

Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy

mBio, 2015
Linezolid is an oxazolidinone with potent activity against Mycobacterium tuberculosis. Linezolid toxicity in patients correlates with the dose and duration of therapy. These toxicities are attributable to the inhibition of mitochondrial protein synthesis.
Ashley N. Brown, George L. Drusano, Jonathan R. Adams, Jaime L. Rodriquez, Kalyani Jambunathan, Dodge L. Baluya, David L. Brown, Awewura Kwara, Jon C. Mirsalis, Richard Hafner, Arnold Louie   +10 more
doaj   +1 more source

Clinical features associated with linezolid resistance among multidrug resistant tuberculosis patients at a tertiary care hospital in Mumbai, India

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2020
Background: Multidrug-resistant tuberculosis (MDR-TB) is an increasing problem worldwide, and 24% occurs in India. Linezolid is associated with improved MDR-TB treatment outcomes but causes significant side-effects and drug susceptibility testing (DST ...
J.A. Tornheim, E. Intini, A. Gupta, Z.F. Udwadia   +3 more
doaj   +1 more source