Results 11 to 20 of about 60,035 (201)

Linezolid-associated neurologic toxicity in patients with drug-resistant tuberculosis in a bedaquiline-based regimen: A scoping review

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2023
Bedaquiline and linezolid have shown a high efficacy in treating drug-resistant tuberculosis (DR-TB). Neurologic toxicity is the primary adverse effect of linezolid, leading to dose reduction or early discontinuation.
Oki Nugraha Putra, Ronald Pratama Adiwinoto   +1 more
doaj   +1 more source

Evaluation of Sensitivity and Resistance of Linezolid in Pre Extensively Drug Resistance Tuberculosis and Extensively Drug Resistance Tuberculosis at a Tertiary Care Hospital, Jamnagar, Gujarat, India [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: The diseases have a high prevalence in India, accounting for one fourth of the Tuberculosis (TB) cases in the world. The situation becomes more complicated due to the rising of Human Immunodeficiency virus/AIDS pandemic, the emergence of ...
Dipali Maganbhai Gavali, Binita Aring, Summiya Mullan, Akhlakahemad A Nathametha, Abhishek B Dave   +4 more
doaj   +1 more source

Different intra-cerebrospinal distribution of linezolid in patients with inflammatory meningitis

International Journal of Infectious Diseases, 2021
Linezolid has excellent antibiotic activity against gram-positive organisms and is expected to be an alternative to vancomycin for the treatment of bacterial meningitis.
Naoki Ichinose, Gakushi Yoshikawa, Eri Fukao, Mai Ichisawa, Tomoaki Takahata, Yuki Enoki, Kazuaki Taguchi, Toshimi Oda, Kazuo Tsutsumi, Kazuaki Matsumoto   +9 more
doaj   +1 more source

Linezolid use in German acute care hospitals: results from two consecutive national point prevalence surveys

Antimicrobial Resistance and Infection Control, 2019
Background Linezolid belongs to a reserve group of antibiotics. In recent years, reports on linezolid resistance in gram-positive cocci have become more frequent. Overuse of linezolid is a relevant factor for resistance development. The objective of this
Tobias Siegfried Kramer, Frank Schwab, Michael Behnke, Sonja Hansen, Petra Gastmeier, Seven Johannes Sam Aghdassi   +5 more
doaj   +1 more source

Severe drug-induced liver injury associated with prolonged use of Linezolid [PDF]

, 2010
This study aims to describe a patient developing concomitant severe liver failure and lactic acidosis after long-term treatment with linezolid. A 55-year-old Caucasian woman developed concomitant severe liver failure and lactic acidosis after a treatment
Benoit, Dominique, De Bus, Liesbet, Depuydt, Pieter, Libbrecht, Louis, NOLLET, JOKE, Van Vlierberghe, Hans, Vandekerckhove, Linos, Vogelaers, Dirk   +7 more
core   +1 more source

Clinical features associated with linezolid resistance among multidrug resistant tuberculosis patients at a tertiary care hospital in Mumbai, India

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2020
Background: Multidrug-resistant tuberculosis (MDR-TB) is an increasing problem worldwide, and 24% occurs in India. Linezolid is associated with improved MDR-TB treatment outcomes but causes significant side-effects and drug susceptibility testing (DST ...
J.A. Tornheim, E. Intini, A. Gupta, Z.F. Udwadia   +3 more
doaj   +1 more source

Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy

mBio, 2015
Linezolid is an oxazolidinone with potent activity against Mycobacterium tuberculosis. Linezolid toxicity in patients correlates with the dose and duration of therapy. These toxicities are attributable to the inhibition of mitochondrial protein synthesis.
Ashley N. Brown, George L. Drusano, Jonathan R. Adams, Jaime L. Rodriquez, Kalyani Jambunathan, Dodge L. Baluya, David L. Brown, Awewura Kwara, Jon C. Mirsalis, Richard Hafner, Arnold Louie   +10 more
doaj   +1 more source

Radezolid Is More Effective Than Linezolid Against Planktonic Cells and Inhibits Enterococcus faecalis Biofilm Formation

Frontiers in Microbiology, 2020
The aim of this study was to compare the effects of radezolid and linezolid on planktonic and biofilm cells of Enterococcus faecalis. A total of 302 E.
Jinxin Zheng, Jinxin Zheng, Zhong Chen, Zhong Chen, Zhiwei Lin, Xiang Sun, Xiang Sun, Bing Bai, Guangjian Xu, Guangjian Xu, Junwen Chen, Zhijian Yu, Di Qu   +12 more
doaj   +1 more source

Linezolid dose adjustment according to therapeutic drug monitoring helps reach the goal concentration in severe patients, and the oldest seniors benefit more

BMC Infectious Diseases, 2023
Background The elderly with severe infection increased dramatically in intensive care unit (ICU). Proper antimicrobial therapy help improve the prognosis.
Ying Xu, Xilan Yang, Pei Liang, Chen Qu
doaj   +1 more source

Circulation of Highly Drug-Resistant Clostridium difficile Ribotypes 027 and 001 in Two Tertiary-Care Hospitals in Mexico [PDF]

, 2018
© 2018, Mary Ann Liebert, Inc.OBJECTIVE: To assess drug susceptibility and characterize Clostridium difficile ribotypes in isolates from two tertiary-care hospitals in Mexico.
Adrian Martinez-Melendez, Adrian, Baines, Simon, Camacho-Ortiz, Adrian, Flores-Trevino, Samantha, Garza-Gonzalez, Elvira, Maldonado-Garza, Hector Jesus, Morfin-Otero, Rayo, Rodrıguez-Noriega, Eduardo, Sanchez-Alanıs, Hugo, Tijerina-Rodrıguez, Laura, Villarreal-Trevino, Licet   +10 more
core   +2 more sources