Results 21 to 30 of about 63,855 (231)

Mechanisms of Linezolid Resistance in Mycobacteria

Pharmaceuticals, 2023
Mycobacteria form some of the most notorious and difficult-to-treat bacterial pathogens. As a group, they are intrinsically resistant to many commonly used antibiotics, such as tetracyclines and beta-lactams.
Wei-Chong Gan, H. F. Ng, Y. Ngeow
semanticscholar   +1 more source

Prolonged use of linezolid in bone and joint infections: a retrospective analysis of adverse effects

Journal of Antimicrobial Chemotherapy, 2023
Objectives Antibiotic treatment for bone and joint infections generally lasts for 6 weeks or longer. Linezolid may be a good option for treating bone and joint infections, but there is an increased risk of potential serious adverse drug events (ADEs ...
Karin Veerman, Jon H. M. Goosen, Karin Spijkers, N. Jager, P. Heesterbeek, D. Telgt   +5 more
semanticscholar   +1 more source

Emergence of linezolid-resistant Enterococcus faecium in a tertiary hospital in Copenhagen

Microbial Genomics, 2023
Linezolid is used as first-line treatment of infections caused by vancomycin-resistant Enterococcus faecium . However, resistance to linezolid is increasingly detected.
Maria-Anna Misiakou, F. B. Hertz, K. Schønning, S. Häussler, K. L. Nielsen   +4 more
semanticscholar   +1 more source

Comparison of Adjuvant Clindamycin vs Linezolid for Severe Invasive Group A Streptococcus Skin and Soft Tissue Infections

Open Forum Infectious Diseases, 2023
Background Linezolid may be an option for severe group A Streptococcus (GAS) infections based on its potent in vitro activity and antitoxin effects, but clinical data supporting its use over clindamycin are limited.
Emily L Heil, Harpreet Kaur, Anthony Atalla, S. Basappa, Minu Mathew, H. Seung, J. Johnson, Gregory M. Schrank   +7 more
semanticscholar   +1 more source

Linezolid-associated neurologic toxicity in patients with drug-resistant tuberculosis in a bedaquiline-based regimen: A scoping review

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine, 2023
Bedaquiline and linezolid have shown a high efficacy in treating drug-resistant tuberculosis (DR-TB). Neurologic toxicity is the primary adverse effect of linezolid, leading to dose reduction or early discontinuation.
Oki Nugraha Putra, Ronald Pratama Adiwinoto   +1 more
doaj   +1 more source

Bedaquiline, pretomanid and linezolid for treatment of extensively drug resistant, intolerant or non-responsive multidrug resistant pulmonary tuberculosis

New England Journal of Medicine, 2020
Background Patients with extensively drug resistant tuberculosis (TB) have limited treatment options with historically poor outcomes. We investigated treatment with 3 oral drugs, bedaquiline (B), pretomanid (Pa) and linezolid (L), (B-Pa-L), with TB ...
F. Conradie, A. Diacon, N. Ngubane, P. Howell, D. Everitt, A. Crook, C. Mendel, E. Egizi, Joanna Moreira, J. Timm, T. McHugh, G. Wills, A. Bateson, R. Hunt, C. V. van Niekerk, Mengchun Li, M. Olugbosi, M. Spigelman   +17 more
semanticscholar   +1 more source

Expert consensus statement on therapeutic drug monitoring and individualization of linezolid

Frontiers in Public Health, 2022
Linezolid is an oxazolidinone antibacterial drug, and its therapeutic drug monitoring and individualized treatment have been challenged since its approval.
B. Lin, Yangmin Hu, Ping Xu, Tao Xu, Chunyan Chen, Lei He, Mi Zhou, Zhang Chen, Chun-Hong Zhang, Xu-Ben Yu, L. Fang, Junfeng Zhu, Yan Ji, Qun Lin, He-Qiong Cao, You-Jun Dai, Xiaoyan Lu, Chang-Cheng Shi, Li Li, Changjiang Wang, Xu-Mei Li, Qi Fang, Jing Miao, Zheng-Yi Zhu, Guangyong Lin, Haichao Zhan, Shiwen Lv, Ya-Lan Zhu, Xin-Jun Cai, Yinqing Ying, Meng Chen, Qiong Xu, Yiwen Zhang, Yu-Bin Xu, F. Pea, Sai-Ping Jiang, Hai-Bin Dai   +36 more
semanticscholar   +1 more source

Different intra-cerebrospinal distribution of linezolid in patients with inflammatory meningitis

International Journal of Infectious Diseases, 2021
Linezolid has excellent antibiotic activity against gram-positive organisms and is expected to be an alternative to vancomycin for the treatment of bacterial meningitis.
Naoki Ichinose, Gakushi Yoshikawa, Eri Fukao, Mai Ichisawa, Tomoaki Takahata, Yuki Enoki, Kazuaki Taguchi, Toshimi Oda, Kazuo Tsutsumi, Kazuaki Matsumoto   +9 more
doaj   +1 more source

Evaluation of Sensitivity and Resistance of Linezolid in Pre Extensively Drug Resistance Tuberculosis and Extensively Drug Resistance Tuberculosis at a Tertiary Care Hospital, Jamnagar, Gujarat, India [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: The diseases have a high prevalence in India, accounting for one fourth of the Tuberculosis (TB) cases in the world. The situation becomes more complicated due to the rising of Human Immunodeficiency virus/AIDS pandemic, the emergence of ...
Dipali Maganbhai Gavali, Binita Aring, Summiya Mullan, Akhlakahemad A Nathametha, Abhishek B Dave   +4 more
doaj   +1 more source

The Global Prevalence of Daptomycin, Tigecycline, and Linezolid-Resistant Enterococcus faecalis and Enterococcus faecium Strains From Human Clinical Samples: A Systematic Review and Meta-Analysis

Frontiers in Medicine, 2021
Background and Aim: The predominant species of the Enterococcus, Enterococcus faecalis (E. faecalis) and Enterococcus faecium (E. faecium) cause great variety of infections.
M. Dadashi, Parastoo Sharifian, Nazila Bostanshirin, Bahareh Hajikhani, N. Bostanghadiri, Nafiseh Khosravi-Dehaghi, A. van Belkum, D. Darban-Sarokhalil   +7 more
semanticscholar   +1 more source