Results 21 to 30 of about 34,465 (168)

Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy.

PLoS ONE, 2013
Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid
Josep M Sierra, Mariana Camoez, Fe Tubau, Oriol Gasch, Miquel Pujol, Rogelio Martin, M Angeles Domínguez   +6 more
doaj   +1 more source

Radezolid Is More Effective Than Linezolid Against Planktonic Cells and Inhibits Enterococcus faecalis Biofilm Formation

Frontiers in Microbiology, 2020
The aim of this study was to compare the effects of radezolid and linezolid on planktonic and biofilm cells of Enterococcus faecalis. A total of 302 E.
Jinxin Zheng, Jinxin Zheng, Zhong Chen, Zhong Chen, Zhiwei Lin, Xiang Sun, Xiang Sun, Bing Bai, Guangjian Xu, Guangjian Xu, Junwen Chen, Zhijian Yu, Di Qu   +12 more
doaj   +1 more source

Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy

mBio, 2015
Linezolid is an oxazolidinone with potent activity against Mycobacterium tuberculosis. Linezolid toxicity in patients correlates with the dose and duration of therapy. These toxicities are attributable to the inhibition of mitochondrial protein synthesis.
Ashley N. Brown, George L. Drusano, Jonathan R. Adams, Jaime L. Rodriquez, Kalyani Jambunathan, Dodge L. Baluya, David L. Brown, Awewura Kwara, Jon C. Mirsalis, Richard Hafner, Arnold Louie   +10 more
doaj   +1 more source

Clinical features associated with linezolid resistance among multidrug resistant tuberculosis patients at a tertiary care hospital in Mumbai, India

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2020
Background: Multidrug-resistant tuberculosis (MDR-TB) is an increasing problem worldwide, and 24% occurs in India. Linezolid is associated with improved MDR-TB treatment outcomes but causes significant side-effects and drug susceptibility testing (DST ...
J.A. Tornheim, E. Intini, A. Gupta, Z.F. Udwadia   +3 more
doaj   +1 more source

Linezolid dose adjustment according to therapeutic drug monitoring helps reach the goal concentration in severe patients, and the oldest seniors benefit more

BMC Infectious Diseases, 2023
Background The elderly with severe infection increased dramatically in intensive care unit (ICU). Proper antimicrobial therapy help improve the prognosis.
Ying Xu, Xilan Yang, Pei Liang, Chen Qu
doaj   +1 more source

Mechanism underlying linezolid-induced peripheral neuropathy in multidrug-resistant tuberculosis

Frontiers in Pharmacology, 2022
Multidrug-resistant tuberculosis (MDR-TB) remains a main global health concern as there is no comprehensive therapeutic intervention yet and numerous adverse effects follow the therapeutic process.
Yuan Yuan, Jinmeng Li, Yanhong Chen, Qingshan Cai, Yingying Xu, Luting Lin, Yazhen Lang, Suhang Guo, Ruoying Zhang, Xinjun Cai   +9 more
doaj   +1 more source

Penetration of linezolid into bone tissue 24 h after administration in patients with multidrug-resistant spinal tuberculosis.

PLoS ONE, 2019
BackgroundLinezolid has shown strong antimicrobial activity against multidrug-resistant (MDR)/rifampin-resistant strains of Mycobacterium tuberculosis.
Yuan Li, Hairong Huang, Weijie Dong, Tinglong Lan, Jun Fan, Shu'an Wen, Tingting Zhang, Shibing Qin, Ai Guo   +8 more
doaj   +1 more source

Linezolid-related adverse drug reactions in patients with drug-resistant tuberculosis: A retrospective study at a government lung hospital [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Drug-resistant tuberculosis (DR-TB) remains a major public health challenge in Indonesia. Treatment outcomes are often compromised by adverse drug reactions (ADRs), particularly those related to prolonged linezolid use.
Emy Oktaviani, Kusnandar Anggadiredja, Lia Amalia   +2 more
doaj   +1 more source

Effects of a rifampicin pre-treatment on linezolid pharmacokinetics.

PLoS ONE, 2019
Linezolid is an oxazolidinone antibiotic that effectively treats methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
Fumiyasu Okazaki, Yasuhiro Tsuji, Yoshihiro Seto, Chika Ogami, Yoshihiro Yamamoto, Hideto To   +5 more
doaj   +1 more source

LINEZOLID

International Journal of Clinical Practice, 2001
SUMMARYMultiple antibiotic resistance is increasing worldwide in Gram‐positive bacteria, especially in hospitals. Problem organisms include multiply resistant strains of pneumococci,Staphylococcus aureusand enterococci; for many of these the glycopeptide vancomycin has become the treatment of last resort.
openaire   +2 more sources