Results 21 to 30 of about 41,531 (223)

Linezolid dose adjustment according to therapeutic drug monitoring helps reach the goal concentration in severe patients, and the oldest seniors benefit more

BMC Infectious Diseases, 2023
Background The elderly with severe infection increased dramatically in intensive care unit (ICU). Proper antimicrobial therapy help improve the prognosis.
Ying Xu, Xilan Yang, Pei Liang, Chen Qu
doaj   +1 more source

Mechanism underlying linezolid-induced peripheral neuropathy in multidrug-resistant tuberculosis

Frontiers in Pharmacology, 2022
Multidrug-resistant tuberculosis (MDR-TB) remains a main global health concern as there is no comprehensive therapeutic intervention yet and numerous adverse effects follow the therapeutic process.
Yuan Yuan, Jinmeng Li, Yanhong Chen, Qingshan Cai, Yingying Xu, Luting Lin, Yazhen Lang, Suhang Guo, Ruoying Zhang, Xinjun Cai   +9 more
doaj   +1 more source

Linezolid-related adverse drug reactions in patients with drug-resistant tuberculosis: A retrospective study at a government lung hospital [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Drug-resistant tuberculosis (DR-TB) remains a major public health challenge in Indonesia. Treatment outcomes are often compromised by adverse drug reactions (ADRs), particularly those related to prolonged linezolid use.
Emy Oktaviani, Kusnandar Anggadiredja, Lia Amalia   +2 more
doaj   +1 more source

Penetration of linezolid into bone tissue 24 h after administration in patients with multidrug-resistant spinal tuberculosis.

PLoS ONE, 2019
BackgroundLinezolid has shown strong antimicrobial activity against multidrug-resistant (MDR)/rifampin-resistant strains of Mycobacterium tuberculosis.
Yuan Li, Hairong Huang, Weijie Dong, Tinglong Lan, Jun Fan, Shu'an Wen, Tingting Zhang, Shibing Qin, Ai Guo   +8 more
doaj   +1 more source

Pan-European early switch/early discharge opportunities exist for hospitalised patients with methicillin-resistant Staphylococcus aureus complicated skin and soft-tissue infections [PDF]

, 2014
The objective was to document pan-European real-world treatment patterns and healthcare resource use and estimate opportunities for early switch (ES) from intravenous (IV) to oral antibiotics and early discharge (ED) in hospitalised patients with ...
Solem, C.T., Haider, S., Macahilig, C., D. Simoneau, W. Lawson, C. Macahilig, Li, J.Z., Stephens, J.M., J.Z. Li, C. Eckmann, S. Haider, R. Chambers, J.M. Stephens, Simoneau, D., Eckmann, C., D. Nathwani, Lawson, W., C.T. Solem, Nathwani, D., Chambers, R., Li, J. Z.   +20 more
core   +1 more source

Effects of a rifampicin pre-treatment on linezolid pharmacokinetics.

PLoS ONE, 2019
Linezolid is an oxazolidinone antibiotic that effectively treats methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE).
Fumiyasu Okazaki, Yasuhiro Tsuji, Yoshihiro Seto, Chika Ogami, Yoshihiro Yamamoto, Hideto To   +5 more
doaj   +1 more source

Compassionate Use of Linezolid for Adult Taiwanese Patients with Bone and Joint Infections

, 2011
Compassionate use of linezolid for bone and joint infections has been reported and hematological adverse reactions are a cause for concern. A similar experience in Asian people has not been reported.
LU, PO-LIANG;WANG, JANN-TAY;CHEN, CHI-LONG;CHEN, WAN-CHIN;CHEN, TUN-CHIEH;HUANG, YHU-CHERING;CHANG, SHAN-CHWEN, 盧柏樑;王振泰;陳志榮;陳婉青;陳惇杰;黃玉成;張上淳   +1 more
core   +1 more source

Immunomodulatory Effect of Linezolid on Methicillin-Resistant Staphylococcus aureus Supernatant-Induced MUC5AC Overexpression in Human Airway Epithelial Cells

, 2014
Linezolid is the first member of the oxazolidinones and is active against drug-resistant Gram-positive pathogens, such as methi-cillin- resistant Staphylococcus aureus (MRSA).
賀来, 敬仁, Yamada, Koichi, Yanagihara, Katsunori, Nagaoka, Kentaro, Kohno, Shigeru, Nakamura, Shigeki, Izumikawa, Koichi, Kaku, Norihito, Migiyama, Yohei, Morinaga, Yoshitomo, Harada, Yosuke   +10 more
core   +1 more source

LINEZOLID

International Journal of Clinical Practice, 2001
SUMMARYMultiple antibiotic resistance is increasing worldwide in Gram‐positive bacteria, especially in hospitals. Problem organisms include multiply resistant strains of pneumococci,Staphylococcus aureusand enterococci; for many of these the glycopeptide vancomycin has become the treatment of last resort.
openaire   +2 more sources

Incidence and risk factors of linezolid-induced lactic acidosis

International Journal of Infectious Diseases, 2015
Background: The use of linezolid has increased with the emergence of multidrug-resistant bacteria. Serum lactic acidosis has been reported as a serious side effect of linezolid use, therefore we evaluated the incidence and characteristics of linezolid ...
Jae Hyoung Im, Ji Hyeon Baek, Hea Yoon Kwon, Jin-Soo Lee   +3 more
doaj   +1 more source