Results 31 to 40 of about 41,531 (223)

The emergence of plasmid-borne cfr-mediated linezolid resistant-staphylococci in Vietnam

Journal of Global Antimicrobial Resistance, 2020
Objectives: Linezolid is one of the last resort antibiotics effectively used in the treatment of infections caused by multidrug-resistant Gram-positive bacteria.
Le Thuy Thi Nguyen, Khanh Ngau Thi Nguyen, Phuc Nhi Thi Anh Le, Fabio Cafini, Ben Pascoe, Samuel K. Sheppard, Thanh Bao Nguyen, Thien Phuc Hoang Nguyen, Thuy Vy Nguyen, Tram T.K. Pham, Kazuya Morikawa, Dang Quan Nguyen, Hoa Xo Duong   +12 more
doaj   +1 more source

Model Based Identification of Linezolid Exposure–toxicity Thresholds in Hospitalized Patients

Frontiers in Pharmacology, 2021
Evidence supports linezolid therapeutic drug monitoring as the exposure–response relationship has been identified for toxicity among patients receiving linezolid, but the data to establish the upper limit are limited and the published toxicity thresholds
Jie Fang, Xiao-Shan Zhang, Xiao-Shan Zhang, Chun-Hong Zhang, Zi-Ye Zhou, Lu Han, Ye-Xuan Wang, Xiao-Shuang He, Xiao-Lan Bian, Guan-Yang Lin, Zheng Jiao, Ying Dai, Xu-Ben Yu, Jing-Ye Pan   +13 more
doaj   +1 more source

Linezolid-associated optic neuropathy cascade in DR-TB patients, Mumbai, India.

, 2016
Linezolid-associated optic neuropathy cascade in DR-TB patients, Mumbai, India.
Mrinalini Das (475810), Salil Mehta (3111570), Petros Isaakidis (316418), Chinmay Laxmeshwar (3111567), Sein Sein Thi (3111576), Sylvie Jonckheere (3111573)   +5 more
core   +1 more source

The in vitro antimicrobial activity of linezolid against unconventional pathogens [PDF]

PeerJ
Linezolid is an oxazolidinone antibiotic that is mainly permitted to treat Gram-positive bacterial infections. Recent studies have shown that linezolid also has antibacterial effects on several other bacteria outside the package insert, including ...
Ting Wang, Huiyue Zhang, Rui Feng, Jieru Ren, Xinping Xu, Shujuan Sun   +5 more
doaj   +2 more sources

Linezolid to treat extensively drug-resistant TB:retrospective data are confirmed by experimental evidence

, 2013
Extensively drug-resistant tuberculosis (XDR-TB) on top of being a growing public health concern, represents a nightmare for the clinician. The crucial therapeutic issue is the difficulty of identifying at least four available ‘‘active’’ anti-TB drugs ...
D'Ambrosio, L., Int Grp Study Linezolid, Zampogna, E., Migliori, G.B., Skrahina, A., Villar, M., Alffenaar, J. W. C., Caminero, J. A., Sotgiu, Giovanni, Migliori, Giovanni Battista, Zellweger, J. P., Sotgiu, G., Spanevello, A., Singla, R., De Lorenzo, S., International Group for the study of Linezolid, Shim, T. S., Zumla, A., Schecter, G. F., Centis, R., Koh, W. J., D'Ambrosio, Lia, Udwadia, Z. F., Anger, H. A., Spanevello, Antonio, Centis, Rosella, Migliori, G. B., Castiglia, P., Ferrara, G.   +28 more
core   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Antibiotic Combinations Preventing Bacterial Resistance: Studies on an in vitro Model with Staphylococcus aureus Exposed to Linezolid–Daptomycin

Антибиотики и Химиотерапия, 2020
To predict the anti-mutant effects of antibiotic combinations against Staphylococcus aureus, the mutant prevention concentrations (MPCs) of linezolid and daptomycin were determined at a linezolid-to-daptomycin concentration ratio that corresponds to the ...
K. N. Alieva, M. V. Golikova, Y. A. Portnoy, A. A. Firsov   +3 more
doaj   +3 more sources

Number of concomitant drugs with thrombocytopenic adverse effects and the extent inflammatory response resolution are risk factors for thrombocytopenia in patients treated with linezolid for more than 14 days [PDF]

, 2020
2020-08Prolonged treatment with linezolid (LZD) is known to cause thrombocytopenia. However, some patients do not develop thrombocytopenia despite long-term administration of LZD.
Morioka, Hiroshi, Iguchi, Mitsutaka, Yamada, Kiyofumi, Yagi, Tetsuya, Sato, Yoshitaka, Tomita, Yuka, Kimura, Hiroshi, Hirabayashi, Aki, Kato, Daizo, Kato, Yoshiaki, Tetsuka, Nobuyuki   +10 more
core   +1 more source

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

British Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval, Sylvain Goutelle, Inesse Boussaha, Xavier Dode, Yanis Mimouni, Kim An Nguyen, Behrouz Kassai   +6 more
wiley   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, EarlyView.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source