Results 31 to 40 of about 63,855 (231)

A Review of Population Pharmacokinetic Analyses of Linezolid

Clinical Pharmacokinetics, 2022
In recent years, many studies on population pharmacokinetics of linezolid have been conducted. This comprehensive review aimed to summarize population pharmacokinetic models of linezolid, by focusing on dosage optimization to maximize the probability of ...
E. Bandín-Vilar, L. García-Quintanilla, Ana Castro-Balado, I. Zarra-Ferro, M. González-Barcia, Manuel Campos-Toimil, V. Mangas-Sanjuán, C. Mondelo-García, A. Fernández-Ferreiro   +8 more
semanticscholar   +1 more source

Immunomodulatory Effect of Linezolid on Methicillin-Resistant Staphylococcus aureus Supernatant-Induced MUC5AC Overexpression in Human Airway Epithelial Cells [PDF]

, 2014
Linezolid is the first member of the oxazolidinones and is active against drug-resistant Gram-positive pathogens, such as methi-cillin- resistant Staphylococcus aureus (MRSA).
賀来, 敬仁, Yamada, Koichi, Yanagihara, Katsunori, Nagaoka, Kentaro, Kohno, Shigeru, Nakamura, Shigeki, Izumikawa, Koichi, Kaku, Norihito, Migiyama, Yohei, Morinaga, Yoshitomo, Harada, Yosuke   +10 more
core   +1 more source

Linezolid use in German acute care hospitals: results from two consecutive national point prevalence surveys

Antimicrobial Resistance and Infection Control, 2019
Background Linezolid belongs to a reserve group of antibiotics. In recent years, reports on linezolid resistance in gram-positive cocci have become more frequent. Overuse of linezolid is a relevant factor for resistance development. The objective of this
Tobias Siegfried Kramer, Frank Schwab, Michael Behnke, Sonja Hansen, Petra Gastmeier, Seven Johannes Sam Aghdassi   +5 more
doaj   +1 more source

Linezolid Metabolism Is Catalyzed by Cytochrome P450 2J2, 4F2, and 1B1

Drug Metabolism And Disposition, 2022
The oxazolidinone antibacterial linezolid has been in clinical use for over 20 years, yet knowledge of the contributions of specific cytochrome (CYP) 450 enzymes to the metabolic clearance of this drug were mostly unknown.
R. Obach
semanticscholar   +1 more source

Radezolid Is More Effective Than Linezolid Against Planktonic Cells and Inhibits Enterococcus faecalis Biofilm Formation

Frontiers in Microbiology, 2020
The aim of this study was to compare the effects of radezolid and linezolid on planktonic and biofilm cells of Enterococcus faecalis. A total of 302 E.
Jinxin Zheng, Jinxin Zheng, Zhong Chen, Zhong Chen, Zhiwei Lin, Xiang Sun, Xiang Sun, Bing Bai, Guangjian Xu, Guangjian Xu, Junwen Chen, Zhijian Yu, Di Qu   +12 more
doaj   +1 more source

Concise Clinical Review of Hematologic Toxicity of Linezolid in Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis: Role of Mitochondria

Tuberculosis and Respiratory Diseases, 2022
Multidrug-resistant tuberculosis (MDR-TB) is caused by an organism that is resistant to both rifampicin and isoniazid. Extensively drug-resistant TB, a rare type of MDR-TB, is caused by an organism that is resistant to quinolone and one of group A TB ...
A. Oehadian, P. Santoso, D. Menzies, R. Ruslami   +3 more
semanticscholar   +1 more source

Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy

mBio, 2015
Linezolid is an oxazolidinone with potent activity against Mycobacterium tuberculosis. Linezolid toxicity in patients correlates with the dose and duration of therapy. These toxicities are attributable to the inhibition of mitochondrial protein synthesis.
Ashley N. Brown, George L. Drusano, Jonathan R. Adams, Jaime L. Rodriquez, Kalyani Jambunathan, Dodge L. Baluya, David L. Brown, Awewura Kwara, Jon C. Mirsalis, Richard Hafner, Arnold Louie   +10 more
doaj   +1 more source

Clinical features associated with linezolid resistance among multidrug resistant tuberculosis patients at a tertiary care hospital in Mumbai, India

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2020
Background: Multidrug-resistant tuberculosis (MDR-TB) is an increasing problem worldwide, and 24% occurs in India. Linezolid is associated with improved MDR-TB treatment outcomes but causes significant side-effects and drug susceptibility testing (DST ...
J.A. Tornheim, E. Intini, A. Gupta, Z.F. Udwadia   +3 more
doaj   +1 more source

Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid.

Journal of Antimicrobial Chemotherapy, 2020
BACKGROUND Improved genetic understanding of Mycobacterium tuberculosis (MTB) resistance to novel and repurposed anti-tubercular agents can aid the development of rapid molecular diagnostics.
S. Kadura, N. King, M. Nakhoul, Hongya Zhu, G. Theron, C. Köser, M. Farhat   +6 more
semanticscholar   +1 more source

The global prevalence of Daptomycin, Tigecycline, Quinupristin/Dalfopristin, and Linezolid-resistant Staphylococcus aureus and coagulase–negative staphylococci strains: a systematic review and meta-analysis

Antimicrobial Resistance and Infection Control, 2020
Methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococcus (MRCoNS) are among the main causes of nosocomial infections, which have caused major problems in recent years due to continuously increasing ...
A. Shariati, M. Dadashi, Z. Chegini, A. van Belkum, M. Mirzaii, S. Khoramrooz, D. Darban-Sarokhalil   +6 more
semanticscholar   +1 more source