Results 51 to 60 of about 60,035 (201)

5-(carbamoylmethylene)-oxazolidin-2-ones as a promising class of heterocycles inducing apoptosis triggered by increased ROS levels and mitochondrial dysfunction in breast and cervical cancer [PDF]

, 2020
Oxazolidinones are antibiotics that inhibit protein synthesis by binding the 50S ribosomal subunit. Recently, numerous worldwide researches focused on their properties and possible involvement in cancer therapy have been conducted.
Armentano, B, Brindisi, M, Cappello, AR, Curcio, R, Dolce, V, Fiorillo, M, Frattaruolo, L, Gabriele, B, Mancuso, R, Rago, V, Ziccarelli, I   +10 more
core   +2 more sources

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

Successful Intra-peritoneal Antibiotic Therapy for Primary Abdominal Nocardiosis in an Immunocompetent Young Female Masquerading as Carcinoma Ovary [PDF]

, 2012
Nocardiosis is a common opportunistic infection in the immunocompromised and in patients with chronic debilitating diseases,e.g continuous ambulatory peritoneal dialysis (CAPD) patients.
Bafna, UD, Pallavi, VR, Patil, RN, Rathod, PS   +3 more
core  

Review of multidrug-resistant and extensively drug-resistant TB: global perspectives with a focus on sub-Saharan Africa [PDF]

, 2010
Tuberculosis (TB) remains a global emergency and is responsible for 1.7 million deaths annually. Widespread global misuse of isoniazid and rifampicin over three decades has resulted in emergence of the ominous spread of multidrug-resistant TB (MDR-TB ...
Abdool Karim, Amor, Balabanova, Caminero, Centers for Disease Control and Prevention, Chan, Chiang, Chiang, Chiang, Churchyard, Dheda, Dravniece, Dubrovina, Elliott, Espinal, Espinal, Espinal, Flament-Saillour, Gandhi, Gandhi, Gandhi, Goble, Grobusch, Habeenzu, Hoek, Holtz, Holtz, Iseman, Johnson, Kehinde, Kim, Kingkaew, Korenromp, Kranzer, Lalloo, Laserson, Lienhardt, Ma, Martin, Matteelli, Meskel, Migliori, Migliori, Migliori, Migliori, Migliori, Moore, Motus, O’Donnell, Pablos-Méndez, Pai, Park, Pietzka, Pillay, Quy, Saravia, Schaaf, Schaaf, Shah, Somocurcio, Sonnenberg, Sotgiu, Torun, Umubyeyi, Wallis, WHO, WHO, WHO and IUATLD, Wright, Wright, Zumla   +70 more
core   +1 more source

Guidelines for Essential Trauma Care: Second Edition (2026)

World Journal of Surgery, EarlyView.
Injury is a major cause of death and disability globally, with the highest burden in low‐ and middle‐income countries (LMICs). Strengthening the organization and planning for trauma care (care of the injured) can improve care and lower mortality. In 2004, the International Association for Trauma Surgery and Intensive Care (IATSIC) and the World Health ...
Charles Mock, Timothy C. Hardcastle, Christine Gaarder, Amit Gupta, Adam Gyedu, Manjul Joshipura, Elmin Steyn, on behalf of the Essential Trauma Care revision author group, Valencia Adjei, Roger Alcock, Vanda Amado, Michael Boampong, Sanjeev Booi, Petra Brysiewicz, Corazon Cabanilla‐Manuntag, Cristiane de Alencar Domingues, Ghada Elhadari, Ranjith Nanda Ellawala, Sarnai Erdene, Ama Akoma Essuman, Jorge Esteban Foianini, Filippo Gatti, Armando Garcia Guererra, Greg Hynes, Adil Haider, Sandy Ingless, Balavenkata Jagannathan, Helen Jowett, Knut Magne Kolstadbråten, Sonja Krofak, Aireen Patricia Madrid, Tina Tomić Mahečić, Claude Martin, Daniel Ntogwrachu, Bisola Onajin‐Obembe, Nhobojit Roy, Andres Rubiano, Niisoja Mensah Torto, Ben Wachira, Meg Walmsley, Torben Wisborg, Elma Wong   +41 more
wiley   +1 more source

Antimicrobial use in European acute care hospitals: results from the second point prevalence survey (PPS) of healthcare-associated infections and antimicrobial use, 2016 to 2017 [PDF]

, 2018
Antimicrobial agents used to treat infections are life-saving. Overuse may result in more frequent adverse effects and emergence of multidrug-resistant microorganisms.
Aghdassi, S., Alberg, T., Arendt, V., Arvaniti, K., Asensio, A., Berg, T. C., Berger-Carbonne, A., Borg, M. A., Bosnjak, Z., Budimir, A., Burns, K., Cairns, S., Cantero, M., Daniau, C., Debacker, M., Deptula, A., Dimina, E., Dobreva, E., Dragovac, G., Florentin, D., Gastmeier, P., Gibbons, C., Gudlaugsson, O., Hadjihannas, L., Hajdu, A., Hansen, S., Harrison, W., Hopkins, S., Hopmans, T., Hristova, R., Ivanov, I. N., Jindrak, V., Johnson, A., Karki, T., Kinross, P., Kontopidou, F., Korosec, A., Latour, K., Litvova, S., Lyytikainen, O., Markovic-Denic, L., Martin, P., McConaghy, M., Mitt, P., Monnet, D. L., Moro, M. L., Nedyalkov, M., Neves, I., Niculcea, A. S., Pacheco, P., Plachouras, D., Presterl, E., Quattrocolo, F., Reilly, J., Rydygier, L., Sartaj, M., Sarvikivi, E., Serban, R. I., Smid, E., Staniulyte, J., Stefkovicova, M., Strauss, R., Suetens, C., Vandael, E., Vilde, A., Weist, K., Zarb, P., Zingg, W., Zotti, C. M., Zupanc, T. L.   +69 more
core   +7 more sources

Enterococcus faecalis and Endodontic Treatment Failure: A Qualitative Systematic Review of Its Role and Elimination Strategies

Australian Endodontic Journal, EarlyView.
ABSTRACT The aim of this study was to synthesize evidence on the influence of Enterococcus faecalis on endodontic treatment failure and strategies for its elimination. This study followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines and was registered in PROSPERO (CRD420251022741).
Francine Santos Fernandes de Lima, Analia Gabriella Borges Ferraz Facury   +1 more
wiley   +1 more source

Impact of Gentamicin‐Impregnated Collagen Sponge on the Incidence of Access Related Infections After Full‐Support Microaxial Flow Pump Therapy

Artificial Organs, EarlyView.
Local application of gentamicin for wound closure after full‐support microaxial flow pump therapy. ABSTRACT Background Surgically implanted microaxial flow pumps (mAFP) are increasingly used for cardiogenic shock treatment. Standard mAFP explantation is performed bedside with a shortening of the vascular prosthesis, which may represent a potential ...
Gaik Nersesian, Maximilian Rauch, Daniel Lewin, Leonard Pitts, Julius Kaemmel, Anna Stegmann, Julia Stein, Yuriy Hrytsyna, Felix Schoenrath, Volkmar Falk, Evgenij Potapov, Pia Lanmueller   +11 more
wiley   +1 more source

Can we prevent antimicrobial resistance by using antimicrobials better? [PDF]

, 2013
Since their development over 60 years ago, antimicrobials have become an integral part of healthcare practice worldwide. Recently, this has been put in jeopardy by the emergence of widespread antimicrobial resistance, which is one of the major problems ...
Brown, Caron, Cars, Cars, Collignon, Dagan, DiNubile, Drlica, Essack, Fox, Geli, Goren, Gould, Guillemot, Harris, Hurdle, Huttner, Isha, Madurell, Masterton, Michalsen, Mitchison, Mitchison, Molstad, Sharma, Solapure, Talbot, Thomas   +27 more
core   +2 more sources

CLINICO–Demographic Profile and Outcomes of Hospitalised Children With Diphtheria in A Tertiary Care Hospital of Peshawar

Acta Paediatrica, EarlyView.
ABSTRACT Aim To determine the clinico‐demographic profile and predictors of mortality in hospitalised children with diphtheria. Methods This retrospective cohort study included 202 children aged 5–16 years diagnosed with diphtheria per WHO criteria at Lady Reading Hospital, Peshawar, from January 2023 to December 2024. Data on demographics, vaccination
Amir Muhammad, Ashfaq Ahmed, Waqas Naseem, Ale Azad Othman, Mohsin Hassan, Lyaba Atta, Muhammad Tahir   +6 more
wiley   +1 more source