Results 51 to 60 of about 41,531 (223)

Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model [PDF]

, 2000
Linezolid, a new oxazolidinone antibiotic, showed good penetration (38+/-4%) into the meninges of rabbits with levels in the CSF ranging from 9.5 to 1.8 mg/L after two i.v. injections (20 mg/kg).
Cottagnoud, M, Gerber, CM, Neftel, K, Täuber, MG, Acosta, F, Cottagnoud, P   +5 more
core   +1 more source

CLINICO–Demographic Profile and Outcomes of Hospitalised Children With Diphtheria in A Tertiary Care Hospital of Peshawar

Acta Paediatrica, EarlyView.
ABSTRACT Aim To determine the clinico‐demographic profile and predictors of mortality in hospitalised children with diphtheria. Methods This retrospective cohort study included 202 children aged 5–16 years diagnosed with diphtheria per WHO criteria at Lady Reading Hospital, Peshawar, from January 2023 to December 2024. Data on demographics, vaccination
Amir Muhammad, Ashfaq Ahmed, Waqas Naseem, Ale Azad Othman, Mohsin Hassan, Lyaba Atta, Muhammad Tahir   +6 more
wiley   +1 more source

Linezolid induced thrombocytopenia

, 2020
Linezolid, an oxazolidinone antibiotic active against gram-positive bacteria is used in the treatment of vancomycin resistant Enterococci and MRSA. It is generally tolerated except for the 32% chance of thrombocytopenia on long term usage of linezolid. A
Muthamil, P.
core   +1 more source

Dermatologic Toxicities Associated With Novel Pan‐RAS/RAF Inhibitors

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background The mitogen‐activated protein kinase (MAPK) pathway plays a key role in cell‐cycle regulation and tumor progression in cancer. Dermatologic toxicities (DTs) to newer pan‐RAS (RMC‐6236) and pan‐RAF (LXH254/naporafenib) inhibitors are emerging.
Lin J. He, Shaymaa Hegazy, Phyu P. Aung, Priyadharsini Nagarajan, Fiorinda Muhaj, Adrienne N. Choksi, Ana M. Ciurea, Kelly C. Nelson, Doina Ivan, Carlos A. Torres‐ Cabala, Victor G. Prieto, Jonathan L. Curry   +11 more
wiley   +1 more source

Mental Health Disorders in End‐Stage Kidney Disease: A Narrative Review of Clinical Considerations for Integrated Management

Hemodialysis International, EarlyView.
ABSTRACT Introduction End stage kidney disease (ESKD) is associated with a high prevalence of depression and anxiety, arising from both biological factors and the psychosocial burden of chronic dialysis care. Approximately 25%–30% of dialysis patients experience clinically significant depressive symptoms when assessed by structured clinical interview ...
Kunal Malhotra, Jordan Fangue‐Nelon, Garima Singh   +2 more
wiley   +1 more source

Differential distribution of linezolid in diseased and nondiseased bones in patients with spinal tuberculosis

BMC Infectious Diseases
Background Linezolid exhibits antibacterial activity against sensitive and drug-resistant strains of Mycobacterium tuberculosis. Knowledge on the distribution of linezolid in different types of bones in patients with spinal tuberculosis (TB) is lacking ...
Yuan Li, Guohua Lei, Weijie Dong, Tinglong Lan, Jun Fan, Shibing Qin   +5 more
doaj   +1 more source

Methicillin‐resistant Staphylococcus aureus bloodstream infections in the Northern Territory of Australia 2017–2022

Internal Medicine Journal, EarlyView.
ABSTRACT Background Methicillin‐resistant Staphylococcus aureus (MRSA) bloodstream infections (BSIs) cause significant morbidity and mortality. In Australia's Northern Territory (NT), MRSA BSI prevalence is disproportionately high. Vancomycin remains standard therapy despite toxicity and complex monitoring requirements.
Sara Davison, Aliya Bryce, Duncan Campbell, Robert Baird, Thomas Ewin, Shahid Ullah, Sonja Janson, Danny Tsai   +7 more
wiley   +1 more source

Platelet‐Rich Fibrins as Local Drug‐Delivery Carriers

Journal of Periodontal Research, EarlyView.
Autologous platelet concentrates (APCs), particularly platelet‐rich fibrin (PRF), act as biologically active fibrin scaffolds, capable of entrapping and gradually releasing therapeutic agents in oral and periodontal therapy. The incorporation of bioactive compounds, such as antibiotics, antifungals, vitamins, antidiabetic drugs, and exosomes, enhances ...
Karim M. Fawzy El‐Sayed, Christof E. Dörfer   +1 more
wiley   +1 more source

Safety of long-term use of linezolid: Results of an open-label study [PDF]

, 2016
Objective: The objective of this study was to assess the long-term safety of linezolid in patients with chronic infections requiring treatment for ≥6 weeks.
Swanson R. N., Vazquez, Jose A., Arnold, Anthony, Arnold AC, Vazquez J. A., Biswas, Pinaki, Biswas P., BASSETTI, MATTEO, Swanson, Robert N., Swanson RN, Swanson, Robert, Bassetti M, Kenreigh, Charlotte, Arnold A. C., Bassetti M., Vazquez JA, Arnold, Anthony C., Biswas P, Vazquez, Jose A   +18 more
core   +1 more source

The effects of far‐UVC irradiation on the presence and concentration of ESKAPEE pathogens on hospital surfaces: Study protocol for a multi‐site, double‐blinded randomized controlled trial in La Paz, Bolivia

Photochemistry and Photobiology, EarlyView.
The protocol of a multi‐site, double‐blinded, clustered randomized controlled trial (cRCT) with a binary outcome of the presence of viable presumptive ESKAPEE pathogens on surfaces in and around hospital sinks is to be implemented in two Bolivian hospitals.
Lindsay B. Saber, Melani Rojas, Darcy M. Anderson, Deverick J. Anderson, Holger Claus, Ryan Cronk, Karl G. Linden, Megan E. J. Lott, Lewis J. Radonovich Jr., Bobby G. Warren, Richard D. Williamson, Richard L. Vincent, Sergio Gutiérrez‐Cortez, Carla Calderón Toledo, Joe Brown   +14 more
wiley   +1 more source