Results 61 to 70 of about 63,855 (231)

A Phase 3, Randomized, Double-Blind Study Comparing Tedizolid Phosphate and Linezolid for Treatment of Ventilated Gram-Positive Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia

Clinical Infectious Diseases, 2021
Background Hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP) are associated with high mortality rates. We evaluated the efficacy and safety of tedizolid (administered as tedizolid phosphate) for treatment ...
R. Wunderink, A. Roquilly, Martin Croce, Daniel Rodríguez González, S. Fujimi, J. Butterton, Natasha Broyde, M. Popejoy, Jason Y Kim, C. De Anda   +9 more
semanticscholar   +1 more source

Innovative methods for the diagnosis and treatment of implant-associated infections [PDF]

, 2009
Indwelling devices and prosthesis are increasingly used in modern medicine practices. Failures of prosthetic joint devices constitute an important complication. Especially, the management of patients with a septic failure is characterized by difficulties
Baldoni, Daniela
core   +1 more source

Therapeutic drug monitoring of linezolid and exploring optimal regimens and a toxicity-related nomogram in elderly patients: a multicentre, prospective, non-interventional study

Journal of Antimicrobial Chemotherapy
Background The concentrations of linezolid, its optimal regimen and the associated side effects in elderly patients remain unclear. Methods In this multicentre, prospective study, elderly patients receiving linezolid at four tertiary hospitals in Beijing
Ting-Ting Liu, Ya-Ping Yuan, Chao Wang, Jiong-He Wu, Ya-Juan Wang, Peng Na, Xiao-Min Chen, Wei-Qiao Rao, Jing Zhao, Dan Wang, Hai-Yan Wang, Zhi-Mei Duan, Fei Xie, Xiang-Qun Fang, Li-Xin Xie, Hong-Xia Li   +15 more
semanticscholar   +1 more source

Linezolid-associated optic neuropathy cascade in DR-TB patients, Mumbai, India.

, 2016
Linezolid-associated optic neuropathy cascade in DR-TB patients, Mumbai, India.
Mrinalini Das (475810), Salil Mehta (3111570), Petros Isaakidis (316418), Chinmay Laxmeshwar (3111567), Sein Sein Thi (3111576), Sylvie Jonckheere (3111573)   +5 more
core   +1 more source

The in vitro antimicrobial activity of linezolid against unconventional pathogens [PDF]

PeerJ
Linezolid is an oxazolidinone antibiotic that is mainly permitted to treat Gram-positive bacterial infections. Recent studies have shown that linezolid also has antibacterial effects on several other bacteria outside the package insert, including ...
Ting Wang, Huiyue Zhang, Rui Feng, Jieru Ren, Xinping Xu, Shujuan Sun   +5 more
doaj   +2 more sources

The emergence of plasmid-borne cfr-mediated linezolid resistant-staphylococci in Vietnam

Journal of Global Antimicrobial Resistance, 2020
Objectives: Linezolid is one of the last resort antibiotics effectively used in the treatment of infections caused by multidrug-resistant Gram-positive bacteria.
Le Thuy Thi Nguyen, Khanh Ngau Thi Nguyen, Phuc Nhi Thi Anh Le, Fabio Cafini, Ben Pascoe, Samuel K. Sheppard, Thanh Bao Nguyen, Thien Phuc Hoang Nguyen, Thuy Vy Nguyen, Tram T.K. Pham, Kazuya Morikawa, Dang Quan Nguyen, Hoa Xo Duong   +12 more
doaj   +1 more source

3D printed PLGA scaffold with nano-hydroxyapatite carrying linezolid for treatment of infected bone defects.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
BACKGROUND Linezolid has been reported to protect against chronic bone and joint infection. In this study, linezolid was loaded into the 3D printed poly (lactic-co-glycolic acid) (PLGA) scaffold with nano-hydroxyapatite (HA) to explore the effect of this
A.li mu Ke re mu, Zhi-Lin Liang, Linlin Chen, Ai ke bai er Tu xun, Maimaitiaili Abulikemu, Yuan-Quan Wu   +5 more
semanticscholar   +1 more source

Low Proportion of Linezolid and Daptomycin Resistance Among Bloodborne Vancomycin-Resistant Enterococcus faecium and Methicillin-Resistant Staphylococcus aureus Infections in Europe

Frontiers in Microbiology, 2021
Vancomycin-resistant Enterococcus faecium (VREF) and methicillin-resistant Staphylococcus aureus (MRSA) are associated with significant health burden. We investigated linezolid and daptomycin resistance among VREF and MRSA in the EU/EEA between 2014 and ...
Robby Markwart, Niklas Willrich, T. Eckmanns, G. Werner, Olaniyi Ayobami   +4 more
semanticscholar   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Linezolid to treat extensively drug-resistant TB:retrospective data are confirmed by experimental evidence

, 2013
Extensively drug-resistant tuberculosis (XDR-TB) on top of being a growing public health concern, represents a nightmare for the clinician. The crucial therapeutic issue is the difficulty of identifying at least four available ‘‘active’’ anti-TB drugs ...
D'Ambrosio, L., Int Grp Study Linezolid, Zampogna, E., Migliori, G.B., Skrahina, A., Villar, M., Alffenaar, J. W. C., Caminero, J. A., Sotgiu, Giovanni, Migliori, Giovanni Battista, Zellweger, J. P., Sotgiu, G., Spanevello, A., Singla, R., De Lorenzo, S., International Group for the study of Linezolid, Shim, T. S., Zumla, A., Schecter, G. F., Centis, R., Koh, W. J., D'Ambrosio, Lia, Udwadia, Z. F., Anger, H. A., Spanevello, Antonio, Centis, Rosella, Migliori, G. B., Castiglia, P., Ferrara, G.   +28 more
core   +1 more source