Results 1 to 10 of about 2,355 (106)

Antibacterial Properties and Computational Insights of Potent Novel Linezolid-Based Oxazolidinones

Pharmaceuticals, 2023
The mounting evidence of bacterial resistance against commonly prescribed antibiotics warrants the development of new antibacterial drugs on an urgent basis.
M. Shaheer Malik, Shaikh Faazil, Meshari A. Alsharif, Qazi Mohammad Sajid Jamal, Jabir H. Al-Fahemi, Amrita Banerjee, Arpita Chattopadhyay, Samir Kumar Pal, Ahmed Kamal, Saleh A. Ahmed   +9 more
doaj   +2 more sources

Efficient fabrication of oxazolidinones for the carboxylative cyclization with carbon dioxide

Journal of CO2 Utilization, 2023
Overuse of fossil energy has accelerated the development of industrialization and improved the quality of human life. However, it also leads to the excessive emission of CO2, and the greenhouse effect is threatening global climate stability and human ...
Xin Yang, Lekai Xu, Yaqiong Zhu, Shaojun Zhang, Guanwei Jia, Jiang Du   +5 more
doaj   +2 more sources

In Vitro Activities of Oxazolidinone Antibiotics Alone and in Combination with C-TEMPO against Methicillin-Resistant Staphylococcus aureus Biofilms

Antibiotics, 2023
Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a global health concern. The propensity of MRSA to form biofilms is a significant contributor to its pathogenicity.
Audrey R. N. Ndukwe, Jilong Qin, Sandra Wiedbrauk, Nathan R. B. Boase, Kathryn E. Fairfull-Smith, Makrina Totsika   +5 more
doaj   +1 more source

Synthesis, mechanism of action, and structure-activity relationships of 1,3-oxazolidinones as anti-bacterial Agent: A review [PDF]

المجلة العراقية للصيدلة, 2022
Background: 1,3-oxazolidinones are an important class of antibiotics that are recognized with higher activities against Gram-positive bacteria. linezolid, tedizolid phosphate, and radezolid are important examples of this group.
Ali Hantosh, Nawal Rajab, Faris Abachi
doaj   +1 more source

Comparative Assessment of Docking Programs for Docking and Virtual Screening of Ribosomal Oxazolidinone Antibacterial Agents

Antibiotics, 2023
Oxazolidinones are a broad-spectrum class of synthetic antibiotics that bind to the 50S ribosomal subunit of Gram-positive and Gram-negative bacteria.
McKenna E. Buckley, Audrey R. N. Ndukwe, Pramod C. Nair, Santu Rana, Kathryn E. Fairfull-Smith, Neha S. Gandhi   +5 more
doaj   +1 more source

Co-Existence of Oxazolidinone Resistance Genes cfr(D) and optrA on Two Streptococcus parasuis Isolates from Swine

Antibiotics, 2023
This study was performed to investigate the presence and characteristics of the oxazolidinone resistance genes optrA and cfr(D) in Streptococcus parasuis.
Ning Han, Jie Li, Peng Wan, Yu Pan, Tiantian Xu, Wenguang Xiong, Zhenling Zeng   +6 more
doaj   +1 more source

5-(Carbamoylmethylene)-oxazolidin-2-ones as a Promising Class of Heterocycles Inducing Apoptosis Triggered by Increased ROS Levels and Mitochondrial Dysfunction in Breast and Cervical Cancer

Biomedicines, 2020
Oxazolidinones are antibiotics that inhibit protein synthesis by binding the 50S ribosomal subunit. Recently, numerous worldwide researches focused on their properties and possible involvement in cancer therapy have been conducted.
Biagio Armentano, Rosita Curcio, Matteo Brindisi, Raffaella Mancuso, Vittoria Rago, Ida Ziccarelli, Luca Frattaruolo, Marco Fiorillo, Vincenza Dolce, Bartolo Gabriele, Anna Rita Cappello   +10 more
doaj   +1 more source

Long-Term Use of Tedizolid in Osteoarticular Infections: Benefits among Oxazolidinone Drugs

Antibiotics, 2021
Background: To evaluate the efficacy and safety of long-term use of tedizolid in osteoarticular infections. Methods: Multicentric retrospective study (January 2017–March 2019) of osteoarticular infection cases treated with tedizolid.
Eva Benavent, Laura Morata, Francesc Escrihuela-Vidal, Esteban Alberto Reynaga, Laura Soldevila, Laia Albiach, Maria Luisa Pedro-Botet, Ariadna Padullés, Alex Soriano, Oscar Murillo   +9 more
doaj   +1 more source

Efficacy of DA-7218, a New Oxazolidinone Prodrug, in the Treatment of Experimental Actinomycetoma Produced by Nocardia brasiliensis

Molecules, 2008
Two recently synthesized oxazolidinones: (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one (DA-7157) and itscorresponding pro-drug (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-2-oxo-5 ...
Lucio Vera-Cabrera, Sung-Hak Choi, Gerardo Lozano-Garza, Salvador Said-Fernandez, Jorge Ocampo-Candiani, Norma Cavazos-Rocha, Noemi Waksman de Torres, Oliverio Welsh, Nelly Alejandra Espinoza-González   +8 more
doaj   +1 more source

Evaluation of CHROMagar™ LIN-R for the Screening of Linezolid Resistant Staphylococci from Positive Blood Cultures and Nasal Swab Screening Samples

Antibiotics, 2022
The increasing number of nosocomial pathogens with resistances towards last resort antibiotics, like linezolid for gram positive bacteria, leads to a pressing need for screening and, consequently, suitable screening media.
Delphine Girlich, Liliana Mihaila, Vincent Cattoir, Frédéric Laurent, Christine Begasse, Florence David, Carole-Ann Metro, Laurent Dortet   +7 more
doaj   +1 more source