5-(Carbamoylmethylene)-oxazolidin-2-ones as a Promising Class of Heterocycles Inducing Apoptosis Triggered by Increased ROS Levels and Mitochondrial Dysfunction in Breast and Cervical Cancer [PDF]
Biomedicines, 2020 Oxazolidinones are antibiotics that inhibit protein synthesis by binding the 50S ribosomal subunit. Recently, numerous worldwide researches focused on their properties and possible involvement in cancer therapy have been conducted.
Biagio Armentano +10 more
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Current Status and Perspectives of Antibacterial Agents Belonging to 2-Oxazolidinones [PDF]
PharmaceuticalsIn the last three decades, 2-oxazolidinones have emerged as an important class of inhibitors of bacterial protein synthesis, effective in the treatment of multidrug-resistant (MDR) bacterial infections. From a public health perspective, the importance of
Jessica Ceramella +9 more
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New Oxazolidinones for Tuberculosis: Are Novel Treatments on the Horizon?
PharmaceuticsMultidrug-resistant tuberculosis (MDR-TB) is a global health concern. Standard treatment involves the use of linezolid, a repurposed oxazolidinone. It is associated with severe adverse effects, including myelosuppression and mitochondrial toxicity.
Ricky Hao Chen +4 more
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Novel and Highly Efficient Carboxylative Cyclization of CO2 to 2-Oxazolidinones Using Nano-SiO2-Supported Ionic Liquid Sustainable Catalysts [PDF]
MoleculesThe conversion of CO2 into 2-oxazolidinones through carboxylative cyclization with propargylic amines is considered an effective method for utilizing waste gas as a sustainable C1 resource and mitigating the greenhouse effect.
Yulin Hu, Zongyan Tang, Xiaobing Liu
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Comparative In Vitro Drug Susceptibility Study of Five Oxazolidinones Against Mycobacterium tuberculosis in Hainan, China [PDF]
PathogensOxazolidinones, novel synthetic antibacterials, inhibit protein biosynthesis and show potent activity against Gram-positive bacteria, including Mycobacterium tuberculosis (MTB).
Jinhui Dong +9 more
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Antibacterial Properties and Computational Insights of Potent Novel Linezolid-Based Oxazolidinones
Pharmaceuticals, 2023 The mounting evidence of bacterial resistance against commonly prescribed antibiotics warrants the development of new antibacterial drugs on an urgent basis.
M. Shaheer Malik +9 more
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Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents [PDF]
ChemistryOpenAn efficient microwave‐assisted synthesis route for novel oxazolidinone analogues has been developed. The general synthesis of these compounds began with an L‐proline‐mediated three‐component Mannich reaction between commercially available 3‐fluoro‐4 ...
Secret P. Els +9 more
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Antibiotics, 2023 Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a global health concern. The propensity of MRSA to form biofilms is a significant contributor to its pathogenicity.
Audrey R. N. Ndukwe +5 more
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Antimicrobial Agents and Chemotherapy, 2023 New oxazolidinones are in clinical development for the treatment of tuberculosis and nontuberculous mycobacterial (NTM) infections, as a replacement for linezolid and tedizolid, which cause mitochondrial toxicity after prolonged treatment.
D. Negatu +4 more
semanticscholar +1 more source
Efficient fabrication of oxazolidinones for the carboxylative cyclization with carbon dioxide
Journal of CO2 Utilization, 2023 Overuse of fossil energy has accelerated the development of industrialization and improved the quality of human life. However, it also leads to the excessive emission of CO2, and the greenhouse effect is threatening global climate stability and human ...
Xin Yang +5 more
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