Results 1 to 10 of about 4,750 (178)

5-(Carbamoylmethylene)-oxazolidin-2-ones as a Promising Class of Heterocycles Inducing Apoptosis Triggered by Increased ROS Levels and Mitochondrial Dysfunction in Breast and Cervical Cancer

Biomedicines, 2020
Oxazolidinones are antibiotics that inhibit protein synthesis by binding the 50S ribosomal subunit. Recently, numerous worldwide researches focused on their properties and possible involvement in cancer therapy have been conducted.
Biagio Armentano, Rosita Curcio, Matteo Brindisi, Raffaella Mancuso, Vittoria Rago, Ida Ziccarelli, Luca Frattaruolo, Marco Fiorillo, Vincenza Dolce, Bartolo Gabriele, Anna Rita Cappello   +10 more
doaj   +1 more source

Efficacy of DA-7218, a New Oxazolidinone Prodrug, in the Treatment of Experimental Actinomycetoma Produced by Nocardia brasiliensis

Molecules, 2008
Two recently synthesized oxazolidinones: (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one (DA-7157) and itscorresponding pro-drug (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-2-oxo-5 ...
Lucio Vera-Cabrera, Sung-Hak Choi, Gerardo Lozano-Garza, Salvador Said-Fernandez, Jorge Ocampo-Candiani, Norma Cavazos-Rocha, Noemi Waksman de Torres, Oliverio Welsh, Nelly Alejandra Espinoza-González   +8 more
doaj   +1 more source

Evaluation of CHROMagar™ LIN-R for the Screening of Linezolid Resistant Staphylococci from Positive Blood Cultures and Nasal Swab Screening Samples

Antibiotics, 2022
The increasing number of nosocomial pathogens with resistances towards last resort antibiotics, like linezolid for gram positive bacteria, leads to a pressing need for screening and, consequently, suitable screening media.
Delphine Girlich, Liliana Mihaila, Vincent Cattoir, Frédéric Laurent, Christine Begasse, Florence David, Carole-Ann Metro, Laurent Dortet   +7 more
doaj   +1 more source

Synthesis and Characterization of Novel Oxazolidinones Via Schiff Base Reactions [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2013
A number of new novel 2,3-disubstituted-1,3-oxazolidine-5-one derivatives were synthesized by the reaction of Schiff‘s bases with chloroacetic acid in dry banzene with high yields. Schiff bases were synthesized by the reaction of heteroaromatic aldehydes
Obaid H.Abid, Aws K. Mohamed
doaj   +1 more source

Evidence Associated with the Use of Oxazolidinones for the Treatment of Skin and Skin Structure Infections: A Retrospective Study

Acta Médica Portuguesa, 2019
Introduction: Skin and skin structure infections are an increasing cause of hospitalization. Although mortality is relatively low, skin and skin structure infections are associated with prolonged hospital length of stay and high costs.
João Gonçalves-Pereira, Filipe Froes, Fernanda Paula Santos, Helena Sofia Antão, João Paulo Guimarães   +4 more
doaj   +1 more source

Ionic Liquid-Promoted Three-Component Domino Reaction of Propargyl Alcohols, Carbon Dioxide and 2-Aminoethanols: A Thermodynamically Favorable Synthesis of 2-Oxazolidinones

Molecules, 2018
To circumvent the thermodynamic limitation of the synthesis of oxazolidinones starting from 2-aminoethanols and CO2 and realize incorporation CO2 under atmospheric pressure, a protic ionic liquid-facilitated three-component reaction of propargyl alcohols,
Shumei Xia, Yu Song, Xuedong Li, Hongru Li, Liang-Nian He   +4 more
doaj   +1 more source

Antimicrobial Effect of Oxazolidinones and Its Synergistic Effect with Bedaquiline Against Mycobacterium abscessus Complex

Infection and Drug Resistance, 2023
Tianhui Gao,1,* Cong Yao,1,* Yuanyuan Shang,1 Renchun Su,1 Xuxia Zhang,1 Weicong Ren,1 Shanshan Li,1 Wei Shu,2 Yu Pang,1 Qi Li2 1Department of Bacteriology and Immunology, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing ...
Gao T, Yao C, Shang Y, Su R, Zhang X, Ren W, Li S, Shu W, Pang Y, Li Q   +9 more
doaj  

The Continuing Threat of Methicillin-Resistant Staphylococcus aureus

Antibiotics, 2019
Staphylococcus aureus has been an exceptionally successful pathogen, which is still relevant in modern age-medicine due to its adaptability and tenacity.
Márió Gajdács
doaj   +1 more source

The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection

Microbiology Spectrum, 2022
Staphylococcus aureus is an important cause of various infections in humans, including bacteremia, skin and soft tissue infections, and infections associated with implanted medical devices.
Oren Gordon, Dustin A. Dikeman, Roger V. Ortines, Yu Wang, Christine Youn, Mohammed Mumtaz, Nicholas Orlando, Jeffrey Zhang, Aman M. Patel, Ethan Gough, Amit Kaushik, Eric L. Nuermberger, Anna M. Upton, Nader Fotouhi, Lloyd S. Miller, Nathan K. Archer   +15 more
doaj   +1 more source

Auto-Tandem Catalysis in Ionic Liquids: Synthesis of 2-Oxazolidinones by Palladium-Catalyzed Oxidative Carbonylation of Propargylic Amines in EmimEtSO4

Molecules, 2016
A convenient carbonylative approach to 2-oxazolidinone derivatives carried out using an ionic liquid (1-ethyl-3-methylimidazolium ethyl sulfate, EmimEtSO4) as the solvent is presented.
Raffaella Mancuso, Asif Maner, Ida Ziccarelli, Christian Pomelli, Cinzia Chiappe, Nicola Della Ca’, Lucia Veltri, Bartolo Gabriele   +7 more
doaj   +1 more source