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Infection and Drug Resistance, 2023 Tianhui Gao,1,* Cong Yao,1,* Yuanyuan Shang,1 Renchun Su,1 Xuxia Zhang,1 Weicong Ren,1 Shanshan Li,1 Wei Shu,2 Yu Pang,1 Qi Li2 1Department of Bacteriology and Immunology, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing ...
Gao T +9 more
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Clinical Pharmacokinetics and Pharmacodynamics of Oxazolidinones [PDF]
Clinical Pharmacokinetics, 2017 Oxazolidinones are a class of synthetic antimicrobial agents with potent activity against a wide range of multidrug-resistant Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. Oxazolidinones exhibit their antibacterial effects by inhibiting protein synthesis acting on the ribosomal 50S ...
Roger, Claire +2 more
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A Critical Review of Oxazolidinones: An Alternative or Replacement for Glycopeptides and Streptogramins? [PDF]
Canadian Journal of Infectious Diseases, 2001 OBJECTIVE: To review the available data on the oxazolidinones linezolid and eperezolid.
George G Zhanel +5 more
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New Oxazolidinones for Tuberculosis: Are Novel Treatments on the Horizon?
PharmaceuticsMultidrug-resistant tuberculosis (MDR-TB) is a global health concern. Standard treatment involves the use of linezolid, a repurposed oxazolidinone. It is associated with severe adverse effects, including myelosuppression and mitochondrial toxicity.
Ricky Hao Chen +4 more
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Palladium-catalyzed formation of oxazolidinones from biscarbamates: a mechanistic study
Beilstein Journal of Organic Chemistry, 2011 Oxazolidinones can be synthesized starting from cyclic biscarbamates via a palladium-catalyzed reaction. To test the proposed mechanism of this reaction, first, bicyclonorcarene endoperoxides derived from cyano and carbomethoxy cycloheptatrienes were ...
Benan Kilbas, Metin Balci
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, 2022 Archive of oxazolidinones containing sub-folders named after each compound and its net charge. Every compound's folder contains a total of 20 files distributed into three sub-directories reporting QM (QM/), FF (FF/), and MD (MD ...
Giuliano Malloci (2060875) +5 more
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Antibiotics, 2022 The increasing number of nosocomial pathogens with resistances towards last resort antibiotics, like linezolid for gram positive bacteria, leads to a pressing need for screening and, consequently, suitable screening media.
Delphine Girlich +7 more
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Ligand-Free Ullmann-Type Arylation of Oxazolidinones by Diaryliodonium Salts
, 2022 The arylation of azaheterocycles can be considered as one of the most important processes for the preparation of various biologically active compounds.
Natalia , Soldatova +7 more
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Synthesis of oxazolidinones from N-aryl-carbamate and epichlorohydrin under mild conditions [PDF]
, 2022 The reaction conditions for an enantiospecific synthesis of various N-aryl-oxazolidinones from N-aryl-carbamates and (R) or (S) epichlorohydrin were optimized.
Buscemi S. +4 more
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Molecules, 2008 Two recently synthesized oxazolidinones: (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one (DA-7157) and itscorresponding pro-drug (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-2-oxo-5 ...
Lucio Vera-Cabrera +8 more
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