A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban
Molecules, 2014 A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step.
Jianyong Yuan, Yanwu Li
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Contezolid in the Treatment of Multidrug-Resistant Tuberculous Meningitis: A Case Report. [PDF]
Clin Case RepABSTRACT Multidrug‐resistant tuberculous meningitis (MDR‐TBM) has a high mortality rate, and treatment options are limited. Linezolid is recommended for refractory cases but often causes intolerable adverse reactions such as peripheral neuropathy. Contezolid, a novel oxazolidinone, has shown better safety profiles in preclinical and early clinical ...
Wang N +10 more
europepmc +2 more sources
LC-MS/MS Method for Simultaneous Quantification of Three Oxazolidinone Antimicrobials in Human Plasma: Application to Therapeutic Drug Monitoring [PDF]
Drug Design, Development and TherapyNa Zhang,* Nan Bai,* Ying Wang, Beibei Liang, Yun Cai Center of Medicine Clinical Research, Department of Pharmacy, Medical Supplies Center, PLA General Hospital, Beijing, 100853, People’s Republic of China*These authors ...
Zhang N, Bai N, Wang Y, Liang B, Cai Y
doaj +2 more sources
Stability-Indicating Assay of Novel 5-(Hydroxamic acid)methyl Oxazolidinones with 5-Lipooxygenase Inhibitory Activity [PDF]
PharmaceuticalsBackground: Oxazolidinone derivatives are a novel class of synthetic antibacterial agents, characterized by a five-membered heterocyclic ring containing oxygen and nitrogen and a carbonyl functionality at position 2. This pharmacophore is responsible not
Hessa M. Al-Mutairi +2 more
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Tetrahedron, 2012 Abstract Two new oxazolidinone polycyclitols, 4,5,7,8,9-pentahydroxy-3-tosyldecahydronaphtho [2,1-d]oxazol-2(9bH)-one and 4,5,6,7,8-pentahydroxy-3-tosyldecahydronaphtho [2,1-d]oxazol-2(9bH)-one were synthesized starting from p-benzoquinone. An endo selective Diels–Alder cycloaddition between p-benzoquinone and 1-acetoxybutadiene followed by ...
Latif Kelebekli, Ertan Şahin
exaly +4 more sources
Cyclic Amide-Linked Oxazolidinone Triazoles as Inhibitors of the T-Box Riboswitch [PDF]
MoleculesAntimicrobial resistance remains a critical global health challenge, and was intensified by the COVID-19 pandemic. To address this growing threat, novel antibacterial agents targeting unconventional mechanisms are urgently needed.
Eric Parsons +6 more
doaj +2 more sources
Synthesis, mechanism of action, and structure-activity relationships of 1,3-oxazolidinones as anti-bacterial Agent: A review [PDF]
المجلة العراقية للصيدلة, 2022 Background: 1,3-oxazolidinones are an important class of antibiotics that are recognized with higher activities against Gram-positive bacteria. linezolid, tedizolid phosphate, and radezolid are important examples of this group.
Ali Hantosh, Nawal Rajab, Faris Abachi
doaj +1 more source
Adding Diversity to Diiron Aminocarbyne Complexes with Amine Ligands
Inorganics, 2023 The reactions of the diiron aminocarbyne complexes [Fe2Cp2(NCMe)(CO)(μ-CO){μ-CN(Me)(R)}]CF3SO3 (R = Me, 1aNCMe; R = Cy, 1bNCMe), freshly prepared from the tricarbonyl precursors 1a–b, with primary amines containing an additional function (i.e., alcohol ...
Chiara Saviozzi +5 more
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Synthesis and Characterization of Some New Oxazolidinone and Thiazolidinone Derivatives Via Reaction of Schiff Bases Derived from some Amino Acids [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2018 New derivatives of 2,3- substituted – oxazolidinone and thiazolidinone were synthesized by cycloaddition reaction of glycolic acid and thioglycolic to various Schiff bases derived from some commercially available amino acids in anhydrous 1,4-dioxane ...
Hajer H. Abbas, Obaid H. Abed
doaj +1 more source
Frontiers in Microbiology, 2022 The appearance of transferable oxazolidinone resistance genes poses a major challenge to public health and environmental safety. These genes not only lead pathogenic bacteria to become resistant to linezolid but also reduce sensitivity to florfenicol ...
Zheren Huang +6 more
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