LC-MS/MS Method for Simultaneous Quantification of Three Oxazolidinone Antimicrobials in Human Plasma: Application to Therapeutic Drug Monitoring [PDF]
Drug Design, Development and TherapyNa Zhang,* Nan Bai,* Ying Wang, Beibei Liang, Yun Cai Center of Medicine Clinical Research, Department of Pharmacy, Medical Supplies Center, PLA General Hospital, Beijing, 100853, People’s Republic of China*These authors ...
Zhang N, Bai N, Wang Y, Liang B, Cai Y
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Stability-Indicating Assay of Novel 5-(Hydroxamic acid)methyl Oxazolidinones with 5-Lipooxygenase Inhibitory Activity [PDF]
PharmaceuticalsBackground: Oxazolidinone derivatives are a novel class of synthetic antibacterial agents, characterized by a five-membered heterocyclic ring containing oxygen and nitrogen and a carbonyl functionality at position 2. This pharmacophore is responsible not
Hessa M. Al-Mutairi +2 more
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Cyclic Amide-Linked Oxazolidinone Triazoles as Inhibitors of the T-Box Riboswitch [PDF]
MoleculesAntimicrobial resistance remains a critical global health challenge, and was intensified by the COVID-19 pandemic. To address this growing threat, novel antibacterial agents targeting unconventional mechanisms are urgently needed.
Eric Parsons +6 more
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Adding Diversity to Diiron Aminocarbyne Complexes with Amine Ligands
Inorganics, 2023 The reactions of the diiron aminocarbyne complexes [Fe2Cp2(NCMe)(CO)(μ-CO){μ-CN(Me)(R)}]CF3SO3 (R = Me, 1aNCMe; R = Cy, 1bNCMe), freshly prepared from the tricarbonyl precursors 1a–b, with primary amines containing an additional function (i.e., alcohol ...
Chiara Saviozzi +5 more
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Synthesis and Characterization of Some New Oxazolidinone and Thiazolidinone Derivatives Via Reaction of Schiff Bases Derived from some Amino Acids [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2018 New derivatives of 2,3- substituted – oxazolidinone and thiazolidinone were synthesized by cycloaddition reaction of glycolic acid and thioglycolic to various Schiff bases derived from some commercially available amino acids in anhydrous 1,4-dioxane ...
Hajer H. Abbas, Obaid H. Abed
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Frontiers in Microbiology, 2022 The appearance of transferable oxazolidinone resistance genes poses a major challenge to public health and environmental safety. These genes not only lead pathogenic bacteria to become resistant to linezolid but also reduce sensitivity to florfenicol ...
Zheren Huang +6 more
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National Journal of Laboratory Medicine, 2023 Introduction: Staphylococcus aureus (S. aureus) is a ubiquitous pathogen causing various infections in humans. The emergence of drug resistance in S. aureus, especially methicillin resistance, has made treating these infections increasingly tricky, with ...
Thammina Meher Srisai Sudhavani +3 more
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Molbank, 2023 An unexpected diastereoselective C-alkylation of a mefloquine derivative in up to 57% yield was the result of an attempted Williamson etherification of Boc-mefloquine.
Dawid J. Kucharski +1 more
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5-(carbamoylmethylene)-oxazolidin-2-ones as a promising class of heterocycles inducing apoptosis triggered by increased ROS levels and mitochondrial dysfunction in breast and cervical cancer [PDF]
, 2020 Oxazolidinones are antibiotics that inhibit protein synthesis by binding the 50S ribosomal subunit. Recently, numerous worldwide researches focused on their properties and possible involvement in cancer therapy have been conducted.
Armentano, B +10 more
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Frontiers in Medicine, 2023 BackgroundContezolid is a novel oxazolidinone antibacterial agent, but there have been no reports of any pertinent clinical studies for the treatment of tuberculosis (TB).
Jun Wang, Liping Ma
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