Results 21 to 30 of about 6,207 (176)
Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria
Molecules, 2020 The introductions of the bicyclic 4-nitroimidazole and the oxazolidinone classes of antimicrobial agents represented the most significant advancements in the infectious disease area during the past two decades.
Zhijun Zhuang +13 more
doaj +1 more source
Syntheses and Crystal Structures of Three Chiral Oxazolidinones with Different Ring Conformations
Crystals, 2022 The preparation of new, enantiomerically pure, α-amino acids from easily available starting materials is an ongoing challenge in synthetic organic chemistry. Here, we describe the syntheses and crystal structures of three chiral oxazolidinone derivatives
Ester Soru +3 more
doaj +1 more source
Antibiotics, 2023 Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a global health concern. The propensity of MRSA to form biofilms is a significant contributor to its pathogenicity.
Audrey R. N. Ndukwe +5 more
doaj +1 more source
New and old oxazolidinones: tedizolid vs. linezolid [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2017 Tedizolid is a novel oxazolidinone that has been recently approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) caused by Gram-positive pathogens, including MRSA.
Dekhnich A.V., Hachatryan N.N.
doaj
Antibacterial Properties and Computational Insights of Potent Novel Linezolid-Based Oxazolidinones
Pharmaceuticals, 2023 The mounting evidence of bacterial resistance against commonly prescribed antibiotics warrants the development of new antibacterial drugs on an urgent basis.
M. Shaheer Malik +9 more
doaj +1 more source
In Vivo Activity of LCB 01-0699, a Prodrug of LCB 01-0648, against Staphylococcus aureus
Molecules, 2017 LCB01-0648 is a novel oxazolidinone compound that shows potent antibacterial activities against most Gram-positive cocci, including the multi-drug resistant Staphylococcus aureus.
Sang-Hun Oh +7 more
doaj +1 more source
Crystal structure of (4R,5S)-4-methyl-3-methylsulfinyl-5-phenyl-1,3-oxazolidin-2-one
Acta Crystallographica Section E, 2014 The absolute structure of the chiral asymmetric indole precursor title compound, C11H13NO3S, was confirmed by refinement of the Flack and Hooft parameters and is that expected based on the starting materials for the synthesis. The phenyl group subtends a
Gustavo Pozza Silveira +2 more
doaj +1 more source
Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents
ChemistryOpenAn efficient microwave‐assisted synthesis route for novel oxazolidinone analogues has been developed. The general synthesis of these compounds began with an L‐proline‐mediated three‐component Mannich reaction between commercially available 3‐fluoro‐4 ...
Secret P. Els +9 more
doaj +1 more source
Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie International Edition, EarlyView.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +1 more source
Truncation of Samroiyotmycin: Tailored seco‐Acids as Novel Antimalaria Compounds
European Journal of Organic Chemistry, EarlyView.Six truncated samroiyotmycin‐derived antimalarials were synthesized by replacing the tosyloxazole unit with electron‐deficient aryl groups. The most active seco‐acid with EWG = 2 × CF3 outperformed the natural product SamA. Its enhanced activity supports a donor–acceptor interaction involving the electron‐poor aryl unit, consistent with inhibition of ...
Anton Czuczkowski +10 more
wiley +1 more source