Results 31 to 40 of about 14,274 (205)

Photoenzymatic Hydroalkylation Enables Streamlined Access to Aryl Glutarimide Precursors

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
We report a photoenzymatic hydroalkylation that enables streamlined, stereocontrolled access to aryl glutarimide precursors relevant to targeted protein degradation. Engineered flavin‐dependent “ene”‐reductases provide broad scope and high enantioselectivity through a distinct electron transfer–enantioselective proton transfer pathway.
Zhi Xu, Prasun Mukherjee, Steven Gossert, Stephen Thomas, Vasil H. Vasilev, Eric R. Welin, Yichen Tan, Shane M. McKenna, Megan A. Emmanuel, Todd K. Hyster   +9 more
wiley   +2 more sources

In Vivo Activity of LCB 01-0699, a Prodrug of LCB 01-0648, against Staphylococcus aureus

Molecules, 2017
LCB01-0648 is a novel oxazolidinone compound that shows potent antibacterial activities against most Gram-positive cocci, including the multi-drug resistant Staphylococcus aureus.
Sang-Hun Oh, Hee-Soo Park, Jun-Hyung Lee, Sung-Yun Baek, Sang-Eun Chae, Kyuman Oh, Young Lag Cho, Jin-Hwan Kwak   +7 more
doaj   +1 more source

Analysis of combined resistance to oxazolidinones and phenicols among bacteria from dogs fed with raw meat/vegetables and the respective food items [PDF]

, 2019
The gene optrA is the first gene that confers resistance to the oxazolidinone tedizolid, a last resort antimicrobial agent in human medicine. In this study we investigated the presence of optrA and the multi-resistance genes poxtA and cfr in enterococci ...
Fan, Run, Feßler, Andrea T., Lei, Lei, Schwarz, Stefan, Wang, Yang, Wang, Yinchao, Wang, Zheng, Wu, Congming, Wu, Yifan   +8 more
core   +1 more source

Synthesis of novel urethanes from a castor oil derived C22-acyloin [PDF]

, 2011
The synthesis of new bio-based chemical building blocks, resulting from the condensation of a renewable C-22 acyloin derived from non-edible castor oil, with mono- and bifunctional isocyanates is reported. The condensation with aliphatic mono-isocyanates
Stevens, Christian, Van der Steen, Marijke, Vilums, Maris   +2 more
core   +2 more sources

Crystal structure of (4R,5S)-4-methyl-3-methylsulfinyl-5-phenyl-1,3-oxazolidin-2-one

Acta Crystallographica Section E, 2014
The absolute structure of the chiral asymmetric indole precursor title compound, C11H13NO3S, was confirmed by refinement of the Flack and Hooft parameters and is that expected based on the starting materials for the synthesis. The phenyl group subtends a
Gustavo Pozza Silveira, Vinicius Flores da Silva, Allen G. Oliver   +2 more
doaj   +1 more source

Synthesis of Ureido-Linked Glycosylated Amino Acids from N α-Fmoc-Asp/Glu-5-oxazolidinones and Their Application to Neoglycopeptide Synthesis [PDF]

, 2008
A simple route for the synthesis of ureido-linked glycosylated amino acids has been described. The key step involves the reaction of isocyanates derived from N α-Fmoc-Asp/Glu-5-oxazolidinones 1 with glycosyl amines followed by hydrolysis.
Sureshbabu, V.V., Venkataramanarao, R.
core   +1 more source

Heterogenisation of ketone catalysts within mesoporous supports for asymmetric epoxidation

, 2013
The synthesis of the first mesoporous silica (150 Å) anchored carbohydrate-derived chiral ketone is described. This new heterogeneous catalyst has been shown to be effective in the asymmetric epoxidation of olefins by oxone.
Adam, Aggarwal, Amadori, Amadori, Armstrong, Beckwith, Bellamy, Bloch, Caprio, Chadwick, Cho, Corey, Denmark, Denmark, Denmark, Dondoni, Farina, Frohn, Goeddel, Heitbaum, Hutchings, Jacobsen, Johansson Seechurn, Johnson, Johnson, Jones, Katsuki, McMorn, Page, Page, Pedragosa-Moreau, Raja, Raynor, Ren, Romesberg, Ross, Sartori, Shephard, Shu, Song, Stearman, Thomas, Thomas, Thomas, Tian, Tian, Tian, van den Broek, Wang, Wang, Wang, Wang, Wong, Wong, Xia, Xiong, Xuereb, Yang, Yang, Zhao, Zhu   +60 more
core   +1 more source

A Divergent Synthetic Approach to Diverse Molecular Scaffolds: Assessment of Lead-Likeness using LLAMA, an Open-Access Computational Tool [PDF]

, 2016
Complementary cyclisation reactions of hex-2-ene-1,6-diamine derivatives were exploited in the synthesis of alternative molecular scaffolds. The value of the synthetic approach was analysed using LLAMA, an open-access computational tool for assessing the
Adam Nelson, Agami, Bemis, Bertrand, Bickerton, Borisov, Christopher J. Empson, Chuprina, Davies, Doveston, Doveston, Firth, Foley, Hann, Ian Churcher, Ignacio Colomer, Irwin, James, James, Jordá-Gregori, Kamiyama, Keserü, Knapp, Leeson, Link, Lipinski, Lipinski, Lipkus, Lovering, Lüthy, MacLellan, Nadin, Oprea, Padwa, Perola, Philip Craven, Richard G. Doveston, Ritchie, Robbins, Ryabukhin, Sauer, Stankov, Stephen P. Marsden, Sudau, Waring, Wee, Wenlock, Zachary Owen   +47 more
core   +1 more source

Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents

ChemistryOpen
An efficient microwave‐assisted synthesis route for novel oxazolidinone analogues has been developed. The general synthesis of these compounds began with an L‐proline‐mediated three‐component Mannich reaction between commercially available 3‐fluoro‐4 ...
Secret P. Els, Kimberleigh B. Govender, Mxolisi K. Sokhela, Nilay Bhatt, Nakita Reddy, Hendrik G. Kruger, Per I. Arvidsson, Hendra Gunosewoyo, Thavendran Govender, Tricia Naicker   +9 more
doaj   +1 more source

Mechanisms of linezolid resistance among coagulase-negative staphylococci determined by whole-genome sequencing. [PDF]

, 2014
UnlabelledLinezolid resistance is uncommon among staphylococci, but approximately 2% of clinical isolates of coagulase-negative staphylococci (CoNS) may exhibit resistance to linezolid (MIC, ≥8 µg/ml).
Bobenchik, April, Charlton, Carmen, Gu, Bing, Hindler, Janet, Humphries, Romney M, Kelesidis, Theodoros, Schork, Nicholas J, Tewhey, Ryan   +7 more
core   +2 more sources