Results 41 to 50 of about 6,207 (176)
Critical role of tedizolid in the treatment of acute bacterial skin and skin structure infections
Drug Design, Development and Therapy, 2016 Olivia Ferrández,1,2 Olatz Urbina,1 Santiago Grau1,3 1Hospital Pharmacy, Hospital Universitari del Mar, Barcelona, Spain; 2Nursing Department, Universitat Pompeu Fabra, Barcelona, Spain; 3Medicine Department, Universitat Autònoma de ...
Ferrández O, Urbina O, Grau S
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In Vitro Activities of LCB 01-0648, a Novel Oxazolidinone, against Gram-Positive Bacteria
Molecules, 2017 Oxazolidinones are a novel class of synthetic antibacterial agents that inhibit bacterial protein synthesis. Here, we synthesized and tested a series of oxazolidinone compounds containing cyclic amidrazone.
Sang-Hun Oh +6 more
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Health Science Reports, Volume 9, Issue 8, August 2026.ABSTRACT Background and Aims Methicillin‐resistant Staphylococcus aureus (MRSA) is a significant pathogen associated with hospital‐acquired infections, with its global prevalence, including in Indonesia, steadily increasing. However, comprehensive data on MRSA prevalence and antimicrobial susceptibility within Indonesian hospital settings remain ...
Muhammad Evy Prastiyanto +2 more
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Total Synthesis of Sacrolide A and Cytotoxic Evaluation
European Journal of Organic Chemistry, Volume 29, Issue 27, 17 July 2026.Isolated from the edible cyanobacterium Aphanothece sacrum, sacrolide A is a highly potent antimicrobial and cytotoxic metabolite. Its total synthesis via a convergent strategy enabled accurate assessment of its effects on liver and colon cells, offering new insights into its bioactivity and potential health risks.
Priyanka Kataria +7 more
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Clinical and Translational ScienceThe objective of this study was to develop a population pharmacokinetic model for linezolid in hematooncological patients with sepsis, and to propose dosing optimization based on pharmacokinetic covariates that would lead to improved achievement of the ...
Alžběta Zavřelová +9 more
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Frontiers in MicrobiologyBackgroundThe emergence of optrA, which can confer resistance to phenicols and oxazolidinones in Enterococcus spp., poses a growing public health threat.Methods102 optrA-positive enterococci (OPEs) including various species were isolated from feces of ...
Yulin Fu +21 more
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(R,R/S,S)-9-Benzyl-3-methyl-7-phenyl-1,6-dioxa-3,9-diazaspiro[4.4]nonane-2,8-dione
IUCrData, 2019 The title compound, C19H18N2O4, a rare example of a spirocyclic orthoamide, was synthesized by a double cyclization of a N-Boc protected sarcosine derivative.
Craig M. Forsyth, Zohreh Nazarian
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Beilstein Journal of Organic Chemistry, 2020 The one-pot reaction of chlorosulfonyl isocyanate (CSI) with epoxides having phenyl, benzyl and fused cyclic alkyl groups in different solvents under mild reaction conditions without additives and catalysts was studied.
Esra Demir +5 more
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Iodine‐Triggered Cyclization of Epoxy Carbamates: A Practical Route to Oxazolidinones
Asian Journal of Organic Chemistry, Volume 15, Issue 7, July 2026.Iodine‐triggered cyclization of epoxy benzyl carbamates to oxazolidinones under mild conditions. The transformation proceeds via SN2‐type epoxide opening followed by 5‐exo‐tet cyclization, delivering C5‐hydroxymethyl‐substituted oxazolidinones with high regioselectivity and no detectable regioisomers.
Yueh‐Ling Huang +3 more
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Crystal structure of (S)-5-(3-acetyl-5-chloro-2-ethoxy-6-fluorophenyl)-2-oxazolidinone
Acta Crystallographica Section E: Crystallographic CommunicationsThe structure of (S)-5-(3-acetyl-5-chloro-2-ethoxy-6-fluorophenyl)-2-oxazolidinone, C13H13ClFNO4, at 100 K has monoclinic (P21) symmetry. The compound has a polymeric structure propagated by a screw axis parallel to the b axis with N—H...O hydrogen ...
Victor Li, Glenn P. A. Yap, Chaoying Ni
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