Results 41 to 50 of about 14,274 (205)
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen +4 more
wiley +1 more source
Concise Synthesis of (+)-allo-Kainic Acid via MgI2-Mediated Tandem Aziridine Ring Opening-Formal [3+2] Cycloaddition [PDF]
, 2013 3-Methyl vinyl aziridine undergoes a mild MgI2-promoted S(N)2' ring opening and concomitant cyclization with fumarate Michael acceptors to give trisubstituted pyrrolidines. The process is efficient and highly diastereoselective. This methodology has been
Aggarwal, Varinder K. +3 more
core +1 more source
Chemistry – A European Journal, EarlyView.Composite materials based on metal nanoparticles supported on a naturally occurring nanotubular clay, halloysite (HAL), led to the diastereoselective hydrogenation of tetra‐substituted alkenes under relatively smooth conditions, mainly oxazolidinone‐based heterocycles.
Rosa Pich +9 more
wiley +1 more source
Molecules, 2023 Comparative chiral separations of enantiomeric pairs of four oxazolidinone and two related thio-derivatives were performed by capillary electrophoresis, using cyclodextrins (CDs) as chiral selectors.
Zoltán-István Szabó +5 more
doaj +1 more source
Physical and chemical quenching rates and their influence on stereoselective photooxygenation of oxazolidinone-functionalized enecarbamates [PDF]
, 2009 Physical and chemical quenching rate constants were measured for the reaction of singlet oxygen with oxazolidinone-functionalized enecarbamates to investigate the role of vibrational deactivation in product ...
Adam, Waldemar +4 more
core +2 more sources
Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application
European Journal of Organic Chemistry, EarlyView.Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley +1 more source
Vibrational assignments of two polymorphic forms of metaxolone by using DFT calculations and the SQM methodology [PDF]
, 2018 A theoretical study has been performed on the musclerelaxant 5-[(3, 5-dimethylphenoxy)methyl]-1,3-oxazolidin-2-one, of generic name metaxolone (MTX), by using the hybridB3LYP/6-31G calculations in the gas phase and theexperimental available infrared and ...
Brandan, Silvia Antonia +3 more
core
Synthesis and biological evaluation of novel PDMP analogues [PDF]
, 2006 A new series of hybrid PDMP analogues, based both on PDMP and styryl analogues of natural ceramide, has been synthesized from D-serine. The synthetic route was developed such that future introduction of different aryl groups is straightforward ...
Boldin-Adamsky, Swetlana +5 more
core +1 more source
European Journal of Organic Chemistry, EarlyView.A chemoenzymatic synthesis of (1R,2S)‐metaraminol was developed by combining gold(I)‐catalysed alkyne hydration and stereoselective biotransamination in a sequential one‐pot process. Various phenol protection strategies were considered in oxidation‐reduction sequences, providing access to enantiopure propargylic alcohols as starting materials for ...
Lorena Escot +2 more
wiley +1 more source
Molecules, 2014 An interesting new approach was developed for the synthesis of Evans’ chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34 ...
Gaspar Diaz +3 more
doaj +1 more source