Results 41 to 50 of about 9,081 (170)

Synthetic Strategies for the Construction of Cyclobutane‐Fused Heterocycles

European Journal of Organic Chemistry, EarlyView.
Cyclobutane‐fused heterocycles are important motifs commonly present in bioactive compounds, recognized for their rigid 3D structures that confer unique properties. However, synthesizing these compounds remains challenging. This review discusses current methods for their synthesis, such as photochemical, metal‐catalyzed, and Lewis acid‐mediated [2 + 2]
Michela Vargiu, Mauro Uras, Angelo Frongia   +2 more
wiley   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Novel oxazolidinones harbor potent in vitro activity against the clinical isolates of multidrug-resistant Mycobacterium tuberculosis in China

Frontiers in Medicine, 2022
ObjectiveTo investigate the in vitro activities of five oxazolidinones in parallel against the reference strains of different mycobacterial species and clinical isolates of Mycobacterium tuberculosis (Mtb), and shed light on the differences in the ...
Chenqian Wang, Chenqian Wang, Guirong Wang, Fengmin Huo, Yi Xue, Junnan Jia, Lingling Dong, Liping Zhao, Fen Wang, Hairong Huang, Hongfei Duan   +10 more
doaj   +1 more source

Urban ants as potential mechanical vectors of pathogenic and antibiotic‐resistant bacteria in a Brazilian hospital

Medical and Veterinary Entomology, EarlyView.
Nine ant taxa were identified in a Brazilian hospital, with Tapinoma melanocephalum and Dorymyrmex brunneus being the most abundant. Eighty‐five percent of collected ants yielded detectable bacterial growth, including clinically relevant genera such as Acinetobacter, Pseudomonas, Escherichia coli and Pluralibacter.
Luana Biggi Souza, Anny Karoliny de Lima Dionisio, Mayara Acioli Cedrim, Luiz Carlos Silva Dias Neto, Ellymaira Freitas Pontes, Yáskara Veruska Ribeiro Barros, Renato Júnior Cavalcante da Silva, Ênio Jose Bassi, Jacques Hubert Charles Delabie, Ana Lucia Biggi Souza, Leticia Anderson   +10 more
wiley   +1 more source

Tedizolid Activity Against Clinical Mycobacterium abscessus Complex Isolates—An in vitro Characterization Study

Frontiers in Microbiology, 2018
Mycobacterium abscessus complex consist of three rapidly growing subspecies: M. abscessus, M. massiliense, and M. bolletii. They are clinically important human pathogens responsible for opportunistic pulmonary and skin and soft tissue infections ...
Ying Wei Tang, Bernadette Cheng, Siang Fei Yeoh, Raymond T. P. Lin, Raymond T. P. Lin, Jeanette W. P. Teo   +5 more
doaj   +1 more source

Patterns of Drug Resistance, Drug Resistance Conferring Mutations and Genomic DNA Methylation Revealed in Mycobacterium tuberculosis From South Africa

Tropical Medicine &International Health, EarlyView.
ABSTRACT Tuberculosis remains a major public health threat globally, with drug‐resistant strains undermining treatment efficacy. We analyzed 126 Mycobacterium tuberculosis (M. tuberculosis) isolates with diverse drug resistance spectra and selected 35 for whole genome sequencing (WGS) using Illumina NextSeq, SMRT PacBio Onso and SMRT PacBio Revio ...
Unarine Matodzi, Awelani Mutshembele, Eric Mensah, Dillon Muzondiwa, Ndivhuho A. Makhado, Oleg N. Reva   +5 more
wiley   +1 more source

Oxazolidinone Antibacterial Agents. An Enantioselective Synthesis of the [6,5,5] Tricyclic Fused Oxazolidinone Ring System and Application to the Synthesis of a Rigid DuP 721 Analogue

, 2016
Oxazolidinone Antibacterial Agents. An Enantioselective Synthesis of the [6,5,5] Tricyclic Fused Oxazolidinone Ring System and Application to the Synthesis of a Rigid DuP 721 ...
D. Mark Gleave (3038250), Steven J. Brickner (439661)   +1 more
core   +1 more source

Critical role of tedizolid in the treatment of acute bacterial skin and skin structure infections

Drug Design, Development and Therapy, 2016
Olivia Ferrández,1,2 Olatz Urbina,1 Santiago Grau1,3 1Hospital Pharmacy, Hospital Universitari del Mar, Barcelona, Spain; 2Nursing Department, Universitat Pompeu Fabra, Barcelona, Spain; 3Medicine Department, Universitat Autònoma de ...
Ferrández O, Urbina O, Grau S
doaj  

In Vitro Activities of LCB 01-0648, a Novel Oxazolidinone, against Gram-Positive Bacteria

Molecules, 2017
Oxazolidinones are a novel class of synthetic antibacterial agents that inhibit bacterial protein synthesis. Here, we synthesized and tested a series of oxazolidinone compounds containing cyclic amidrazone.
Sang-Hun Oh, Josep Kim, Sung-Yoon Baek, Sang-Eun Chae, Hee-Soo Park, Young-Lag Cho, Jin-Hwan Kwak   +6 more
doaj   +1 more source

Synthesis and Fluorescence Profiling of Naphthylamine Analogs

ChemBioChem, Volume 27, Issue 19, 14 October 2026.
N‐phenyl‐1‐naphthylamine (NPN) has been historically used as a probe to monitor gram‐negative bacterial outer membrane permeabilization, fluorescing only in hydrophobic environments. Herein, a 95‐membered naphthylamine library was synthesized to explore structure–fluorescence relationships, informed by density functional theory studies.
Cole M. Friederichs, Jackson W. Berryman, Quentin M. R. Gibaut, Inga V. Leus, Chloe F. Cox, Helen I. Zgurskaya, Adam S. Duerfeldt   +6 more
wiley   +1 more source