Results 61 to 70 of about 14,274 (205)

N-TERMINAL PROCESSING OF RIBOSOMAL PROTEIN L27 IN STAPHYLOCOCCUS AUREUS [PDF]

, 2012
The bacterial ribosome is essential to cell growth yet little is known about how its proteins attain their mature structures. Recent studies indicate that certain Staphlyococcus aureus bacteriophage protein sequences contain specific sites that may be ...
Caufield, J. Harry
core   +1 more source

Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid. [PDF]

, 2007
Linezolid, which targets the ribosome, is a new synthetic antibiotic that is used for treatment of infections caused by Gram-positive pathogens. Clinical resistance to linezolid, so far, has been developing only slowly and has involved exclusively target
Arias, Cesar A, Lolans, Karen, Mankin, Alexander S, Quinn, John, Toh, Seok-Ming, Villegas, Maria V, Xiong, Liqun   +6 more
core   +1 more source

Oxazolidinone polycyclitols. Stereospecific synthesis of novel aminocarbasugars with oxazolidinone ring

Tetrahedron, 2012
Abstract Two new oxazolidinone polycyclitols, 4,5,7,8,9-pentahydroxy-3-tosyldecahydronaphtho [2,1-d]oxazol-2(9bH)-one and 4,5,6,7,8-pentahydroxy-3-tosyldecahydronaphtho [2,1-d]oxazol-2(9bH)-one were synthesized starting from p-benzoquinone. An endo selective Diels–Alder cycloaddition between p-benzoquinone and 1-acetoxybutadiene followed by ...
Kelebekli, Latif, Balci, Neslihan, Sahin, Ertan   +2 more
openaire   +3 more sources

Synthesis and use of a stable aminal derived from TsDPEN in asymmetric organocatalysis [PDF]

, 2010
A stable aminal formed stereoselectively from (R,R)-N-tosyl-1,2-diphenyl-1,2-ethylenediamine (TsDPEN) is capable of asymmetric organocatalysis of Diels-Alder and alpha-amination reactions of ...
Clarkson, Guy J., Gosiewska, Silvia, Soni, Rina, Wills, Martin   +3 more
core   +1 more source

Population Pharmacokinetic Model‐Based Optimization of Linezolid Dosing in Hematooncological Patients With Suspected or Proven Gram‐Positive Sepsis

Clinical and Translational Science
The objective of this study was to develop a population pharmacokinetic model for linezolid in hematooncological patients with sepsis, and to propose dosing optimization based on pharmacokinetic covariates that would lead to improved achievement of the ...
Alžběta Zavřelová, Sara Merdita, Pavel Žák, Jakub Radocha, Benjamin Víšek, Miriam Lánská, Jana Maláková, Pavel Michálek, Ondřej Slanař, Martin Šíma   +9 more
doaj   +1 more source

High prevalence and plasmidome diversity of optrA-positive enterococci in a Shenzhen community, China

Frontiers in Microbiology
BackgroundThe emergence of optrA, which can confer resistance to phenicols and oxazolidinones in Enterococcus spp., poses a growing public health threat.Methods102 optrA-positive enterococci (OPEs) including various species were isolated from feces of ...
Yulin Fu, Zhaoju Deng, Yingbo Shen, Weizhou Wei, Qiumei Xiang, Zhiyang Liu, Kunning Hanf, Suli Huang, Suli Huang, Zexun Lv, Tingting Cao, Changfeng Peng, Rong Zhang, Xuan Zou, Jianzhong Shen, Stefan Schwarz, Stefan Schwarz, Stefan Schwarz, Yang Wang, Dejun Liu, Ziquan Lv, Yuebin Ke   +21 more
doaj   +1 more source

(R,R/S,S)-9-Benzyl-3-methyl-7-phenyl-1,6-dioxa-3,9-diazaspiro[4.4]nonane-2,8-dione

IUCrData, 2019
The title compound, C19H18N2O4, a rare example of a spirocyclic orthoamide, was synthesized by a double cyclization of a N-Boc protected sarcosine derivative.
Craig M. Forsyth, Zohreh Nazarian
doaj   +1 more source

One-pot synthesis of oxazolidinones and five-membered cyclic carbonates from epoxides and chlorosulfonyl isocyanate: theoretical evidence for an asynchronous concerted pathway

Beilstein Journal of Organic Chemistry, 2020
The one-pot reaction of chlorosulfonyl isocyanate (CSI) with epoxides having phenyl, benzyl and fused cyclic alkyl groups in different solvents under mild reaction conditions without additives and catalysts was studied.
Esra Demir, Ozlem Sari, Yasin Çetinkaya, Ufuk Atmaca, Safiye Sağ Erdem, Murat Çelik   +5 more
doaj   +1 more source

Stereoselective E/Z photoisomerization of oxazolidinone functionalized enecarbamates: direct and triplet sensitized irradiation [PDF]

, 2005
Oxazolidinone-functionalized enecarbamates undergo diastereoselective E/Z photoisomerization upon direct and triplet sensitized irradiations with chiral/achiral sensitizers, showing that the enhanced product diastereoselectivity depends on the solvent ...
Adam, Waldemar, Inoue, Yoshihisa, Jockusch, Steffen, Saito, Hideaki, Sivaguru, Jayaraman, Turro, Nicholas J.   +5 more
core   +2 more sources

Substitutive Approach Toward Heteroaromatic Amino Alcohols Accessed Through Dioxolanyl Radical Linchpin

Advanced Synthesis &Catalysis, Volume 368, Issue 7, 1 April 2026.
A dioxolanyl linchpin has been used to synthesize aryl ethanolamines from readily available aryl bromide and amine starting materials using a metallaphotoredox/substitution telescoped sequence. This combinatorial approach allows for a wide synthetic scope of both heteroarenes and cyclic amines. Aryl ethanolamines are an important functional group found
Justin J. Chang, Munnu Kumar, Ryan C. Kashatus, Dylan J. Tomaselli, Daniel K. Kim   +4 more
wiley   +1 more source