Results 61 to 70 of about 9,081 (170)

(R,R/S,S)-9-Benzyl-3-methyl-7-phenyl-1,6-dioxa-3,9-diazaspiro[4.4]nonane-2,8-dione

IUCrData, 2019
The title compound, C19H18N2O4, a rare example of a spirocyclic orthoamide, was synthesized by a double cyclization of a N-Boc protected sarcosine derivative.
Craig M. Forsyth, Zohreh Nazarian
doaj   +1 more source

One-pot synthesis of oxazolidinones and five-membered cyclic carbonates from epoxides and chlorosulfonyl isocyanate: theoretical evidence for an asynchronous concerted pathway

Beilstein Journal of Organic Chemistry, 2020
The one-pot reaction of chlorosulfonyl isocyanate (CSI) with epoxides having phenyl, benzyl and fused cyclic alkyl groups in different solvents under mild reaction conditions without additives and catalysts was studied.
Esra Demir, Ozlem Sari, Yasin Çetinkaya, Ufuk Atmaca, Safiye Sağ Erdem, Murat Çelik   +5 more
doaj   +1 more source

Truncation of Samroiyotmycin: Tailored seco‐Acids as Novel Antimalaria Compounds

European Journal of Organic Chemistry, Volume 29, Issue 34, 11 September 2026.
Six truncated samroiyotmycin‐derived antimalarials were synthesized by replacing the tosyloxazole unit with electron‐deficient aryl groups. The most active seco‐acid with EWG = 2 × CF3 outperformed the natural product SamA. Its enhanced activity supports a donor–acceptor interaction involving the electron‐poor aryl unit, consistent with inhibition of ...
Anton Czuczkowski, Anja Schäfer, Juliana A. Hüther, Bianca Wank, Robert Toews, Fotios Fotakis, Andreas Köhn, Markus Rehm, Matthias Rottmann, Anna Zens, Sabine Laschat   +10 more
wiley   +1 more source

Sonication-Assisted Library Synthesis of Oxazolidinone−Carbohydrate Conjugates

, 2007
Oxazolidinone derivatives have attracted growing interest in their pharmacological ...
Chen, Hsiao-Nung, Chiang, Fang-I, Takemoto, Jon Y., Chang, Cheng-Wei Tom, Zhang, Jianjun, Bensaci, Mekki   +5 more
core   +1 more source

Expedient Synthesis of Chiral Oxazolidinone Scaffolds via Rhodium-Catalyzed Asymmetric Ring-Opening with Sodium Cyanate

, 2016
A method for synthesizing chiral oxazolidinone scaffolds from readily available oxabicyclic alkenes is described. The reaction utilizes a domino sequence of Rh(I)-catalyzed asymmetric ring-opening (ARO) with sodium cyanate as a novel nucleophile followed
Akihito Hosotani (1986520), Mark Lautens (1391935), Gavin Chit Tsui (1951060), Nina M. Ninnemann (1850728)   +3 more
core   +2 more sources

Design, Synthesis, In Silico Studies, and HIV‐1 RT Inhibitory Activity of 1,3‐Oxazolidine Pyrimidine Nucleoside Analogues

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Previously synthesized 1,3‐oxazolidine pyrimidine nucleoside analogues (S1–S6) were evaluated for HIV‐1 reverse transcriptase inhibition using molecular docking, ADMET prediction, and an in vitro colorimetric HIV‐RT assay. Compounds S4 and S5 exhibited the strongest binding affinities and moderate enzyme inhibition (IC50 = 19.27 and 22.80 µM ...
Shimoga Nagaraj Sriharsha, Zaid Mahmood Mohamed, Ammar A. Razzak Mahmood, Sibghatullah Muhammad Ali Sangi, Sadik Shaik, Sreeharsha Nagaraja, Sheeba Kumari, Vidhya Thirunavukkarasu, Pavan Kumar Sreenivasalu, Monirul Islam, Muhammad Shahzad Chohan, Mahalakshmi Suresha Biradar   +11 more
wiley   +1 more source

Opposing auxiliary conformations produce the same torquoselectivity in an oxazolidinone-directed Nazarov cyclization

, 2013
Most applications of chiral oxazolidinone auxiliaries in asymmetric synthesis operate through a common set of stereocontrol principles. That is, the oxazolidinone is made to adopt a specific, coplanar conformation with respect to the prochiral substrate,
Flynn, Bernard L., Manchala, Narasimhulu, Krenske, Elizabeth H.   +2 more
core   +1 more source

Microwave-Assisted Condensation of Two Potential Antibacterial Pharmacophores (Sulfonamide and Oxazolidinone)

Engineering Proceedings
In recent years, microwave heating has become a widely used technique in organic synthesis. The reactions take place within a very short time, under mild conditions with high yields, and produce pure and selective compounds with fewer side reactions.
Radia Bouasla, Malika Berredjem
doaj   +1 more source

Methamphetamine Enantiomers: From Chemical Synthesis to Biological Fate

Chirality, Volume 38, Issue 9, September 2026.
Methamphetamine is an amphetamine‐type stimulant characterized by a single stereogenic center, resulting in two enantiomers, (R)‐(−)‐methamphetamine and (S)‐(+)‐methamphetamine, with distinct biological and pharmacological profiles. These forms exhibit differences in central nervous system activity, metabolism, excretion, and overall physiological ...
Larissa Pires do Espírito Santo, Renato Lúcio de Carvalho, Juliana Almeida Sad, Pedro Henrique Costa dos Santos, Rhaiza Silva Domingues, Gabriele de Azevedo Cardoso, Karine Braga Enes, Gisele Assis Castro Goulart, Maila de Castro Lourenço das Neves, Ângelo de Fátima   +9 more
wiley   +1 more source

Opposing Auxiliary Conformations Produce the Same Torquoselectivity in an Oxazolidinone-Directed Nazarov Cyclization

, 2016
Most applications of chiral oxazolidinone auxiliaries in asymmetric synthesis operate through a common set of stereocontrol principles. That is, the oxazolidinone is made to adopt a specific, coplanar conformation with respect to the prochiral substrate,
Bernard L. Flynn (1399213), Narasimhulu Manchala (1923514), Elizabeth H. Krenske (1333482)   +2 more
core   +1 more source