Results 71 to 80 of about 14,274 (205)

Crystal structure of (S)-5-(3-acetyl-5-chloro-2-ethoxy-6-fluorophenyl)-2-oxazolidinone

open access: yesActa Crystallographica Section E: Crystallographic Communications
The structure of (S)-5-(3-acetyl-5-chloro-2-ethoxy-6-fluorophenyl)-2-oxazolidinone, C13H13ClFNO4, at 100 K has monoclinic (P21) symmetry. The compound has a polymeric structure propagated by a screw axis parallel to the b axis with N—H...O hydrogen ...
Victor Li, Glenn P. A. Yap, Chaoying Ni
doaj   +1 more source

Patent developments in antimycobacterial small-molecule therapeutics [PDF]

open access: yes, 2005
At. present, clinical management of patients infected with Mycobacterium tuberculosis faces difficult problems, such as the worldwide emergence of multidrug resistant tuberculosis (MDR-TB), and the increase in AIDS-associated infections.
Van Calenbergh, Serge, Van Daele, Ineke
core   +2 more sources

Divergent Silylmagnesiation of Ynamides: An Efficient and Versatile Entry to Polysubstituted Enamides

open access: yesChemistryEurope, Volume 4, Issue 4, April 2026.
A set of selective and divergent procedures for the silylmetallation of ynamides is reported. Upon simple reaction with a silyl‐Grignard reagent in the presence of catalytic amounts of copper bromide, a β‐selective, syn‐silylmagnesiation occurs affording a unique and selective access to polysubstituted silylated enamides.
Thibault Heymans, Gwilherm Evano
wiley   +1 more source

Catalyst‐Free Mass Polymerization and Characterization of Bio‐Polyhydroxhyurethanes Based on Resorcinol Bis(Cyclocarbonate)

open access: yesMacromolecular Materials and Engineering, Volume 311, Issue 4, April 2026.
Non‐isocyanate polyhydroxyurethanes (PHUs) were synthesized from resorcinol bis(cyclocarbonate) and eco‐friendly diamines under mild, catalyst‐free conditions. The resulting polymers were extensively characterized for their structural, thermal, and mechanical properties, as well as processability and adhesion performance.
Federico Olivieri   +9 more
wiley   +1 more source

NCY‐1 β‐Lactamase Activity Correlates With Antimicrobial Susceptibility of a Clinical Strain of Nocardia cyriacigeorgica

open access: yesMicrobiologyOpen, Volume 15, Issue 2, April 2026.
This study shows a strong correlation between the β‐lactam susceptibility profile of a clinical isolate of Nocardia cyriacigeorgica and the activity of its β‐lactamase, NCY‐1. Inhibitors of NCY‐1 reduce the minimum inhibitory concentration of amoxicillin.
Julie Couston   +8 more
wiley   +1 more source

Structure of ethyl 2-​(2-​amino-​3-​ethoxycarbonyl-​4H-​chromen-​4-​yl)​-​2-​cyanoacetate [PDF]

open access: yes, 1992
The title compd. is monoclinic, space group P21/n, with a 21.335(2)​, b 8.516(1)​, c 9.273(1) Å, and β 93.645(1)​°, Z = 4, dm = 1.330, dc = 1.305, T = 300 K, final R = 0.059 for 3184 reflections. At. coordinates are given. The dihydropyran ring makes a
Kokila, MK   +4 more
core   +2 more sources

The Influence of COVID‐19 on the Composition and Drug Resistance of Pleural Effusion in Shandong Province

open access: yesMicrobiologyOpen, Volume 15, Issue 2, April 2026.
Our results show that the COVID‐19 pandemic has a significant impact on the detection of pathogens and drug resistance in pleural effusion in Shandong Province. ABSTRACT To analyze the composition and drug resistance changes of pleural effusion in Shandong region from 2017 to 2024, and to provide a basis for clinical empirical treatment and future ...
Wenwen Yu   +60 more
wiley   +1 more source

Microwave-Assisted Condensation of Two Potential Antibacterial Pharmacophores (Sulfonamide and Oxazolidinone)

open access: yesEngineering Proceedings
In recent years, microwave heating has become a widely used technique in organic synthesis. The reactions take place within a very short time, under mild conditions with high yields, and produce pure and selective compounds with fewer side reactions.
Radia Bouasla, Malika Berredjem
doaj   +1 more source

Enantioselective Synthesis of Dialkylated N-Heterocycles by Palladium-Catalyzed Allylic Alkylation [PDF]

open access: yes, 2015
The enantioselective synthesis of α-disubstituted N-heterocyclic carbonyl compounds has been accomplished using palladium-catalyzed allylic alkylation.
Houk, K. N.   +4 more
core   +2 more sources

Antimicrobial Effect of Spices and Their Phytochemicals: A Novel Approach to Overcoming Antibiotic Resistance

open access: yesMedComm, Volume 7, Issue 4, April 2026.
This graphical abstract shows the antibacterial potential of phytochemicals from 15 spices, showcasing key compounds, their extraction methods, and mechanisms of action. It highlights membrane disruption, ROS generation, enzyme inhibition, and biofilm prevention as core antibacterial pathways.
Hettiyahandi Binodh De Silva   +3 more
wiley   +1 more source

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