Results 71 to 80 of about 9,081 (170)
A new oxazolidinone antimicrobial [PDF]
, 2016 Purpose. The mechanism of action, pharmacokinetics, pharmacodynamics, and clinical efficacy and safety of an investigational second-generation oxazolidinone are reviewed. Summary. Tedizolid is a protein synthesis inhibitor in clinical development for the
Kisgen, Jamie J. +3 more
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Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.A novel series of benzisothiazole‐based hydrazide derivatives was designed, synthesized, and evaluated for antitubercular activity. Compound 8k emerged as the most potent candidate (MIC = 0.25 μg/mL) with a high selectivity index (SI = 42) and bactericidal activity. Molecular docking and 100 ns simulations identified InhA as the probable target.
Vivek Sharma +3 more
wiley +1 more source
, 2022 Florfenicol is widely used for the treatment of bacterial infections in domestic animals. The aim of this study was to analyze the molecular mechanisms of florfenicol and oxazolidinone resistance in Enterococcus isolates from anal feces of domestic ...
Tielun Yan (13152162) +14 more
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Flipping the Card With Enantiodivergent Organocatalysis
Chemistry – A European Journal, Volume 32, Issue 29, 7 August 2026.This minireview elaborates on recent organocatalytic strategies for achieving enantiodivergence—the ability to access both product enantiomers using a single chiral catalyst. It highlights how achiral stimuli, such as solvent polarity and chemical additives, along with minimal catalyst modifications, trigger stereochemical inversions in reactions ...
Debora Iapadre +3 more
wiley +1 more source
Evans Enolates: Solution Structures of Lithiated Oxazolidinone-Derived Enolates
, 2015 The results of a combination of 6Li and 13C NMR spectroscopic and computational studies of oxazolidinone-based lithium enolatesEvans enolatesin tetrahydrofuran (THF) solution revealed a mixture of dimers, tetramers, and oligomers (possibly ladders ...
David B. Collum (1308378) +1 more
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, 2022 Florfenicol is widely used for the treatment of bacterial infections in domestic animals. The aim of this study was to analyze the molecular mechanisms of florfenicol and oxazolidinone resistance in Enterococcus isolates from anal feces of domestic ...
Tielun Yan (13152162) +14 more
core +1 more source
Drug Development Research, Volume 87, Issue 5, August 2026.ABSTRACT A novel series of 5‐chloro‐N‐alkyl‐1′,1″‐dimethyl‐4′‐aryldispiro[indene‐2,3′‐pyrrolidine‐2′,3″‐indoline]−1,2″(3H)‐diones (4a–r) was rationally designed and synthesized via a one‐pot multicomponent reaction of N‐alkylated 5‐chloroisatin derivatives, 2‐(arylmethylidene)−2,3‐dihydro‐1H‐inden‐1‐ones (2a–i), and sarcosine (3).
Aisha A. Alsfouk +7 more
wiley +1 more source
In vitro Susceptibility of Nontuberculous Mycobacteria to Tedizolid
Infection and Drug Resistance, 2022 Huiyun Zhang,1 Wenya Hua,1 Siran Lin,1 Yu Zhang,1 Xinchang Chen,1 Shiyong Wang,1 Jiazhen Chen,1 Wenhong Zhang1– 3 1Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center
Zhang H +7 more
doaj
, 2007 The development of resistance by the antibiotics in the Gram-positive pathogenic bacteria over the last twenty years and continuing today has created a need for new antibiotic classes, which may be unaffected by existing bacterial resistance.
BOTTA, Bruno +5 more
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Reduction of N-(γ- or δ-oxoacyl)oxazolidinone [PDF]
application/pdfWe expected that treatment of optically active N-(γ- or δ-oxoacyl)oxazolidinone 6 or 7 with a reducing agent resulted in the formation of optically active lactone 9 or 11.
Yamaguchi, Jun-ichi +7 more
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