Results 81 to 90 of about 14,274 (205)

Chemistry and Biology of Streptogramin A Antibiotics [PDF]

, 2007
The streptogramin A antibiotics have proven to be highly active against Gram positive bacteria, particularly methicillin-resistant Staphylococcus aureus. Members of this group of compounds are characterized by a 23-membered macrocycles containing polyene,
Ahmed, Fahim, Donaldson, William
core   +1 more source

Continuous N-alkylation reactions of amino alcohols using γ-Al2O3 and supercritical CO2: unexpected formation of cyclic ureas and urethanes by reaction with CO2 [PDF]

, 2017
The use of γ-Al2O3 as a heterogeneous catalyst in scCO2, has be successfully applied to the amination of alcohols for the synthesis of N-alkylated heterocycles.
George, Michael W., Lee, Darren S., Poliakoff, Martyn, Streng, Emelia S.   +3 more
core   +2 more sources

Identification of Natural Isonitriles Through Ligation to an Azomethine Imine Probe

Chemistry – A European Journal, Volume 32, Issue 11, 16 March 2026.
The azomethine imine (AMI)–isonitrile (NC) ligation allowed for the chemoselective detection of natural isonitriles in bacteria and fungi. The reactivity‐based screening establishes a new stereogenic center, thereby allowing for facile distinction between chiral and achiral isonitriles. The work also unraveled a unique reactivity of isonitriles bearing
Maurice P. Biedermann, Alexander Brachmann, Shurui Mai, Athanasios Markos, Markus Künzler, Jörn Piel, Helma Wennemers   +6 more
wiley   +1 more source

Combination of a UPO‐Based Epoxidation With a Subsequent Ring‐Opening Reaction for the Synthesis of Amino Alcohols

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
The synthesis of aromatic amino alcohols via a combination of an unspecific peroxygenase‐catalysed reaction, oxyfunctionalization, and addition of selected nucleophiles and electrophiles in a highly atom‐efficient manner was investigated. This study presents the design to aim for an atom‐efficient chemo‐enzymatic synthesis route towards aromatic amino ...
Simon Last, Niklas Dietz, Martin J. Weissenborn, Jan von Langermann   +3 more
wiley   +1 more source

In vitro Susceptibility of Nontuberculous Mycobacteria to Tedizolid

Infection and Drug Resistance, 2022
Huiyun Zhang,1 Wenya Hua,1 Siran Lin,1 Yu Zhang,1 Xinchang Chen,1 Shiyong Wang,1 Jiazhen Chen,1 Wenhong Zhang1– 3 1Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center
Zhang H, Hua W, Lin S, Zhang Y, Chen X, Wang S, Chen J, Zhang W   +7 more
doaj  

Investigation of linezolid resistance in staphylococci and enterococci [PDF]

, 2016
The objective of this study was to investigate an apparent increase in linezolid-nonsusceptible staphylococci and enterococci following a laboratory change in antimicrobial susceptibility testing from disk diffusion to an automated susceptibility testing
Alspaugh, Debbie, Burnham, Carey-Ann D, Doern, Christopher D, Gallegos, Michael, Park, Jason Y   +4 more
core   +2 more sources

Linezolid pharmacokinetics in MDR-TB : a systematic review, meta-analysis and Monte Carlo simulation [PDF]

, 2018
This work was supported by the Wellcome Trust (grant numbers 109129/Z/15/Z to JM and 105620/Z/14/Z to DS and MC).Objectives The oxazolidinone linezolid is an effective component of drug - resistant TB treatment, but use is limited by toxicity and the ...
Alffenaar, Jan-Willem C, Bolhuis, Mathieu, Bonnett, Laura, Caws, Maxine, Dartois, Véronique, Davies, Geraint, Johnson, John L, Millard, James, Model, Eva Maria, Pertinez, Henry, Sloan, Derek James, Tiberi, Simon   +11 more
core   +5 more sources

Controlled diastereoselectivity at the alkene-geometry through selective encapsulation: E-Z photoisomerization of oxazolidinone-functionalized enecarbamates within hydrophobic nano-cavities [PDF]

, 2007
Photoisomerization of encapsulated Z-enecarbamates within the hydrophobic chiral cavities of γ-CD showed higher diastereoselectivities in the photoproducts than those obtained in solution.
Adam, Waldemar, Dyer, Joanne, Inoue, Yoshihisa, Jockusch, Steffen, Saito, Hideaki, Sivaguru, J., Turro, Nicholas J.   +6 more
core   +2 more sources

Bacterial resistance to antimicrobial agents and its impact on veterinary and human medicine [PDF]

, 2016
Background Antimicrobial resistance has become a major challenge in veterinary medicine, particularly in the context of bacterial pathogens that play a role in both humans and animals.
Aarestrup, Abedon, Arais, Becker, Bikard, Blondeau, Brackman, Bradford, Brandenburg, Brogden, Burrus, Bush, Bush, Bywater, Chopra, Clinical and Laboratory Standards Institute, Clinical and Laboratory Standards Institute, Clinical and Laboratory Standards Institute, Connell, Couto, Cuny, D'Costa, Damborg, Duijkeren, Ewers, Ewers, Falgenhauer, Feßler, Fischetti, Fuente-Núñez, Giessen, Goh, Grobbel, Grobbel, Groves, Guardabassi, Hall, Harada, Harrison, Hill, Hillier, International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements (IWG-SCC), Kadlec, Kadlec, Kadlec, Kadlec, Kehrenberg, Köck, Laube, Lefebvre, Lindsay, Lloyd, Long, Lyon, Lüthje, Maaland, Maddox, Magiorakos, Mascaretti, McCarthy, McCarthy, McNulty, Michael, Michael, Michael, Moodley, Mueller, Nienhoff, Nobrega, O'Neill, Paterson, Perreten, Poole, Putman, Ramirez, Redgrave, Richter, Riesenberg, Roberts, Roberts, Roberts, Ruiz, Rule, Schaufler, Schmiedel, Schneider, Schuch, Schultz, Schwarz, Schwarz, Schwarz, Schwarz, Schwarz, Schwarz, Schwarz, Schwarz, Schwarz, Schwarz, Scott, Shen, Sing, Soares, Sobral, Thandar, Thomas, Tsonos, van, von, Walther, Wang, Weiß, Wendlandt, Wendlandt, Wendlandt, Wendlandt, Wendlandt, Werckenthin, Westgarth, Westgarth, White, Wu, Zervos, Zhao, Zurek   +123 more
core   +3 more sources

Resistance to Linezolid Caused by Modifications at Its Binding Site on the Ribosome [PDF]

, 2012
Linezolid is an oxazolidinone antibiotic in clinical use for the treatment of serious infections of resistant Gram-positive bacteria. It inhibits protein synthesis by binding to the peptidyl transferase center on the ribosome. Almost all known resistance
Long, Katherine S., Vester, Birte
core   +1 more source