Results 101 to 110 of about 14,274 (205)
, 2017 Since 2010 the new antimicrobials introduced have activity against resistant Gram negative bacteria, long half-lives against Gram positive bacteria, better activity against Clostridium difficile, and safer antifungal properties. Limiting factors to using
Roland, Will
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Palladium-catalyzed formation of oxazolidinones from biscarbamates: a mechanistic study
Beilstein Journal of Organic Chemistry, 2011 Oxazolidinones can be synthesized starting from cyclic biscarbamates via a palladium-catalyzed reaction. To test the proposed mechanism of this reaction, first, bicyclonorcarene endoperoxides derived from cyano and carbomethoxy cycloheptatrienes were ...
Benan Kilbas, Metin Balci
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VirulenceAs antibiotic resistance escalates into a global health crisis, novel therapeutic approaches against infectious diseases are in urgent need. Pseudomonas aeruginosa, an adaptable opportunistic pathogen, poses substantial challenges in treating a range of ...
Yi Wu +6 more
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An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents
Journal of Chemistry, 2013 Oxazolidinone, either mononuclear or condensed with other heterocyclics, has established its importance in medicinal chemistry. A variety of biological activities have been reported by oxazolidinone derivatives.
Kavita Devi +4 more
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Linezolid Susceptibility And Potential Resistance Mechanisms Among Mrsa Isolated From Two Major Public Hospitals In Malaysia [PDF]
, 2014 Linezolid is the first antibiotic of a new structural class, the oxazolidinones, to be approved for clinical use in 35 years. This antimicrobial agent is broadly effective against drug-resistant gram-positive pathogens which commonly cause infections ...
Thiruchelvi , Pulingam
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Design and synthesize oxazolidinone NAAA inhibitors，evaluate its pharmacological effects and toxicity [PDF]
, 2015 研究背景：N-棕榈酰乙醇胺（N-palmitoylethanolamide,PEA）是一种内源性的脂质，通过抑制内源性大麻素水解酶N-酰基乙醇胺水解酶（NAAA）的活性可有效提高细胞和动物机体内PEA浓度，从而发挥镇痛，抗炎，抗癫痫，神经保护等作用。然而现有的NAAA抑制剂活性低、稳定性差，无法应用于整体动物实验和口服给药，所以研制出新型的NAAA抑制剂成了当务之急。 目的：本研究通过设计合成一系列噁唑烷酮类NAAA抑制剂，从中寻找到结构稳定，活性强，毒副作用小的化合物 ...
李燕婷
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Kinetic and Mechanistic Investigation of Asymmetric Organocatalytic Reactions
, 2008 The utilisation of the reaction progress kinetic methodology to advance the mechanistic understanding of the asymmetric proline catalysed aldol and α-aminoxylation reactions is demonstrated in this work.
Zotova, Natalia, Zotova, Natalia
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Synthesis of a new class of aminocyclitol analogues with the conduramine D-2 configuration
Beilstein Journal of Organic Chemistry, 2010 A new class of aminocyclitol derivatives with the bicyclo[4.2.0]octane skeleton was synthesized starting from cyclooctatetraene. Photooxygenation of trans-7,8-diacetoxy- and cis-7,8-dichlorobicyclo[4.2.0]octa-2,4-diene afforded the bicyclic endoperoxides.
Latif Kelebekli, Yunus Kara, Murat Celik
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E-Journal of Chemistry, 2011 A new synthetic method for the preparation of high enantiopure (R)-2-((2-oxooxazolidin-5-yl)methyl)isoindoline-1,3-dione has been developed. The enantiopurity of the obtained (R)-2-((2-oxooxazolidin-5-yl)methyl) isoindoline-1,3-dione is established ...
T. Rajesh +4 more
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Linezolid: The First Oxazolidinone Antimicrobial
Annals of Internal Medicine, 2003 Linezolid is the first of a new class of antimicrobial agents, the oxazolidinones, to be approved for clinical use in the United States and elsewhere. The drug is a totally synthetic compound, which lessens the likelihood of naturally occurring resistance mechanisms.
openaire +2 more sources