Results 1 to 10 of about 5,076 (258)

One-pot synthesis of substituted pyrrolo[3,4-b]pyridine-4,5-diones based on the reaction of N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-2-arylethyl)acetamide with amines

Beilstein Journal of Organic Chemistry, 2019
The condensation of primary amines with N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-2-arylethyl)acetamides was explored. Thus, a previously unknown recyclization of the starting material was observed in acidic ethanol in the presence of an amine,
Valeriya G. Melekhina, Andrey N. Komogortsev, Boris V. Lichitsky, Vitaly S. Mityanov, Artem N. Fakhrutdinov, Arkady A. Dudinov, Vasily A. Migulin, Yulia V. Nelyubina, Elizaveta K. Melnikova, Michail M. Krayushkin   +9 more
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Thermische Umlagerung von Benzyl-1-alkinyl-äthern in Gegenwart von Aminen

CHIMIA, 1972
The benzyl-l-alkynyl ethers 1a and 1b in the presence of ammonia or diethylamine at 50 to 80° are transformed into the corresponding o-tolyl-acetamides 4 to 6 (scheme 1). This observation gives good evidence that benzyl-1-alkynyl ethers 1 rearrange by a
A. Wunderli, J. Zsindely, H.-J. Hansen, H. Schmid   +3 more
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Design and synthesis of some novel 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)-N-(4-(substituted)phenyl)acetamide derivatives for biological evaluation as anticonvulsant agents

Bulletin of Faculty of Pharmacy Cairo University, 2013
A new series of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)-N-(4-substitutedphenyl)acetamides (2–15a–c) were designed and synthesized in order to evaluate their anticonvulsant activity.
Mohamed-Kamal Ibrahim, Ashraf A. Abd-Elrahman, Rezk R.A. Ayyad, Khaled El-Adl, Ahmed M. Mansour, Ibrahim H. Eissa   +5 more
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Synthesis of new 2-{2,3-dihydro-1,4-benzodioxin-6-yl[(4-methylphenyl) sulfonyl]amino}-N-(un/substituted-phenyl)acetamides as α-glucosidase and acetylcholinesterase inhibitors and their in silico study

Brazilian Journal of Pharmaceutical Sciences
The aim of the present research work was to investigate the enzyme inhibitory potential of some new sulfonamides having benzodioxane and acetamide moieties.
Muhammad Athar Abbasi, Sajid Riaz, Aziz-ur- Rehman, Sabahat Zahra Siddiqui, Syed Adnan Ali Shah, Muhammad Ashraf, Muhammad Arif Lodhi, Farman Ali Khan   +7 more
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Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones

Molecules, 2010
A series of Schiff’s bases (E)-N-2-aryliden-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazides 2a-l and N-(2-(substituted phenyl)-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamides 3a-l were synthesized and evaluated for their ...
Valentina Rajković, Bojan Šarkanj, Elizabeta Has-Schön, Milan Čačić, Maja Molnar   +4 more
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Synthesis and biological evaluation of Schiff bases and azetidinones of 1-naphthol

Journal of Pharmacy and Bioallied Sciences, 2012
Introduction: Schiff bases and azetidinones form an important structural class possessing wide spectrum of biological activities that include antibacterial and antifungal activity.
Sushil Kumar, Punit Kumar, Nitin Sati
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Synthesis and characterization of some novel diaryl urea derivatives bearing quinoxalindione moiety

Research in Pharmaceutical Sciences, 2018
Diaryl urea derivatives have exhibited a broad spectrum of biochemical effects and pharmaceutical applications. Several diaryl urea derivatives such as sorafenib, regorafenib, linifanib, and tivozanib and lenvatinib are in clinical trial or clinical use.
Sedighe Sadeghian-Rizi, Ghadamali Khodarahmi, Amirhossein Sakhteman, Ali Jahanian-Najafabadi, Mahboubeh Rostami, Mahmoud Mirzaei, Farshid Hassanzadeh   +6 more
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Crystal structures of two C,N-disubstituted acetamides: 2-(4-chlorophenyl)-N-(2-iodophenyl)acetamide and 2-(4-chlorophenyl)-N-(pyrazin-2-yl)acetamide

Acta Crystallographica Section E: Crystallographic Communications, 2016
In the crystal of 2-(4-chlorophenyl)-N-(2-iodophenyl)acetamide, C14H11ClINO, molecules are linked by a combination of N—H...O and C—H...O hydrogen bonds to form a C(4)C(4)[R21(7)] chain of rings and chains of this type are linked by a combination of C—Cl.
Badiadka Narayana, Hemmige S. Yathirajan, Ravindranath Rathore, Christopher Glidewell   +3 more
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Synthesis and antiexudative activityof pyrolin derivatives 2 - ((4-amino-5- (furan-2-yl)-1,2,4-triazol-4H-3-il)-sulfanil)-N-acetamides

Фармацевтичний журнал, 2019
The continuous research of new effective drugs is associated with a significant number of diseases, pathological conditions. Conventional treatment with existing drugs could be ineffective, or addictive, and have a large number of side effects. Therefore,
N. M. Chalenko, P. A. Bezugly, A. O. Sirova, I. S. Chekman, A.M. Demchenko   +4 more
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Three-Component Reaction of 3-Arylidene-3H-Indolium Salts, Isocyanides, and Alcohols

Frontiers in Chemistry, 2019
A novel isocyanide-based multicomponent synthesis of alkyl aryl(indol-3-yl)acetimidates has been established. Starting from aryl(indol-3-yl)methylium tetrafluoroborates, aromatic isocyanides and alcohols, the imidates were obtained in moderate to very ...
Nikita E. Golantsov, Hung M. Nguyen, Alexandra S. Golubenkova, Alexey V. Varlamov, Erik V. Van der Eycken, Erik V. Van der Eycken, Leonid G. Voskressensky   +6 more
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