Results 1 to 10 of about 4,030 (217)

Bis-pyrimidine acetamides: design, synthesis and biological evaluation

Chemistry Central Journal, 2017
Background In the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents.
Sanjiv Kumar, Siong Meng Lim, Kalavathy Ramasamy, Mani Vasudevan, Syed Adnan Ali Shah, Balasubramanian Narasimhan   +5 more
doaj   +1 more source

Intramolecular Carbene C-H Insertion Reactions of 2-Diazo-2-sulfamoylacetamides

Molecules, 2019
The intramolecular C-H insertions of carbenes derived from 2-diazo-2-sulfamoylacetamides were studied. 2-Diazo-2-sulfamoylacetamides were first prepared from chloroacetyl chloride and secondary amines through acylation followed by sequential treatments ...
Chuqiang Que, Peipei Huang, Zhanhui Yang, Ning Chen, Jiaxi Xu   +4 more
doaj   +1 more source

Synthesis and Antimicrobial Activity of Some Novel Substituted Piperazinyl-quinazolin-3(4H)-ones

E-Journal of Chemistry, 2008
Several substituted-quinazolin-3(4H)-ones were synthesized by condensation of 2-chloro-N-(4-oxo-substituted-quinazolin-3(4H)-yl)-acetamides with various substituted piperazines through single step reaction. Elemental analysis, IR, 1HNMR and mass spectral
N. M. Raghavendra, P. P. Thampi, P. M. Gurubasavarajaswamy   +2 more
doaj   +1 more source

Approach for the synthesis of N-phenylamides from β-ketobutylanilides using dimethylformamide and dimethylacetamide as the acyl donors

Journal of Saudi Chemical Society, 2015
A new method including the sequence of a CN bond formation of β-keto amides with N,N-dimethylamides and subsequently another two CN bonds cleavage has been developed in the presence of hydrochloric acid.
Cui Chen, Liquan Tan, Peng Zhou
doaj   +1 more source

Design and synthesis of some novel 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)-N-(4-(substituted)phenyl)acetamide derivatives for biological evaluation as anticonvulsant agents

Bulletin of Faculty of Pharmacy Cairo University, 2013
A new series of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)-N-(4-substitutedphenyl)acetamides (2–15a–c) were designed and synthesized in order to evaluate their anticonvulsant activity.
Mohamed-Kamal Ibrahim, Ashraf A. Abd-Elrahman, Rezk R.A. Ayyad, Khaled El-Adl, Ahmed M. Mansour, Ibrahim H. Eissa   +5 more
doaj   +1 more source

Thermische Umlagerung von Benzyl-1-alkinyl-äthern in Gegenwart von Aminen

CHIMIA, 1972
The benzyl-l-alkynyl ethers 1a and 1b in the presence of ammonia or diethylamine at 50 to 80° are transformed into the corresponding o-tolyl-acetamides 4 to 6 (scheme 1). This observation gives good evidence that benzyl-1-alkynyl ethers 1 rearrange by a
A. Wunderli, J. Zsindely, H.-J. Hansen, H. Schmid   +3 more
doaj   +1 more source

Synthesis of new 2-{2,3-dihydro-1,4-benzodioxin-6-yl[(4-methylphenyl) sulfonyl]amino}-N-(un/substituted-phenyl)acetamides as α-glucosidase and acetylcholinesterase inhibitors and their in silico study

Brazilian Journal of Pharmaceutical Sciences
The aim of the present research work was to investigate the enzyme inhibitory potential of some new sulfonamides having benzodioxane and acetamide moieties.
Muhammad Athar Abbasi, Sajid Riaz, Aziz-ur- Rehman, Sabahat Zahra Siddiqui, Syed Adnan Ali Shah, Muhammad Ashraf, Muhammad Arif Lodhi, Farman Ali Khan   +7 more
doaj   +1 more source

One-pot synthesis of substituted pyrrolo[3,4-b]pyridine-4,5-diones based on the reaction of N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-2-arylethyl)acetamide with amines

Beilstein Journal of Organic Chemistry, 2019
The condensation of primary amines with N-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)-2-oxo-2-arylethyl)acetamides was explored. Thus, a previously unknown recyclization of the starting material was observed in acidic ethanol in the presence of an amine,
Valeriya G. Melekhina, Andrey N. Komogortsev, Boris V. Lichitsky, Vitaly S. Mityanov, Artem N. Fakhrutdinov, Arkady A. Dudinov, Vasily A. Migulin, Yulia V. Nelyubina, Elizaveta K. Melnikova, Michail M. Krayushkin   +9 more
doaj   +1 more source

Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones

Molecules, 2010
A series of Schiff’s bases (E)-N-2-aryliden-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazides 2a-l and N-(2-(substituted phenyl)-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamides 3a-l were synthesized and evaluated for their ...
Valentina Rajković, Bojan Šarkanj, Elizabeta Has-Schön, Milan Čačić, Maja Molnar   +4 more
doaj   +1 more source

Synthesis and biological evaluation of Schiff bases and azetidinones of 1-naphthol

Journal of Pharmacy and Bioallied Sciences, 2012
Introduction: Schiff bases and azetidinones form an important structural class possessing wide spectrum of biological activities that include antibacterial and antifungal activity.
Sushil Kumar, Punit Kumar, Nitin Sati
doaj   +1 more source