Results 11 to 20 of about 5,076 (258)

Novel Chalcone Derivatives as Anti-Leishmania infantum Agents with Potential Synergistic Activity and In Silico Insights [PDF]

Antibiotics
Background: Visceral leishmaniasis (VL) is a neglected tropical disease with limited therapeutic options, often restricted by toxicity, high costs, and resistance. Chalcones are promising scaffolds for the development of antiparasitic agents. Objectives:
Ana Letícia Monteiro Fernandes, Abraão Pinheiro Sousa, Delva Thyares Fonseca Lamec, Leonardo Lima Cardoso, Rosália Santos Ferreira, Shayenne Eduarda Ramos Vanderley, Petrônio Filgueiras Athayde-Filho, Gabriela Fehn Fiss, Tatjana Souza Lima Keesen   +8 more
doaj   +2 more sources

Synthesis and antitumor activity of 1,3,4-oxadiazole substituted 2-(5-ylidene-2,4-dioxothiazolidin-3-yl)-acetamides [PDF]

Pharmacia, 2023
A series of novel 1,3,4-oxadiazole substituted 2-(5-aryl/heterylidene-2,4-dioxothiazolidine-3-ylidene)-acetamides and their 5-unsubstituted analogues have been synthesized following N-alkylation reaction of 2-chloro-N-(5-aryl-[1,3,4]oxadiazol-2-yl ...
Maryan Lelyukh, Myroslava Kalytovska, Marta Zastryzhna, Arkadii Savchenko, Ihor Chaban, Stefan Harkov   +5 more
doaj   +4 more sources

Regioselective synthesis of anilines and β-dibrominated acetamides from N-aryl acetoacetamides mediated by Cu(I) salts

Journal of Saudi Chemical Society, 2016
A highly regioselective synthetic strategy mediated by Cu(I) salts is presented for the synthesis of anilines and β-dibrominated acetamides from N-aryl acetoacetamides.
Li-Quan Tan, Wei-Bing Liu, Peng Zhou, Cui Chen, Qing Zhang   +4 more
doaj   +2 more sources

Synthesis, characterization, antimicrobial, cytotoxic and carbonic anhydrase inhibition activities of multifunctional pyrazolo-1,2-benzothiazine acetamides [PDF]

Beilstein Journal of Organic Chemistry
The advent of antibiotic resistance in microorganisms requires the discovery and synthesis of novel antibiotics. At the same time, human pathogens are contributing to chronic and persistent inflammation.
Ayesha Saeed, Shahana Ehsan, Muhammad Zia-ur-Rehman, Erin M. Marshall, Sandra Loesgen, Abdus Saleem, Simone Giovannuzzi, Claudiu T. Supuran   +7 more
doaj   +2 more sources

N-(9,10-Dioxo-9,10-dihydroanthracen-1(2)-yl)-2-(R-thio) Acetamides: Synthesis, Antioxidant and Antiplatelet Activity

Acta Chimica Slovenica, 2022
The synthesis of new N-(9,10-dioxo-9,10-dihydroanthracen-1(2)-yl)-2-(R-thio) acetamides was carried out using reaction of 2-chloro-N-(9,10-dioxo-9,10-dihydroanthracene-1(2)-yl)acetamides with functionalized thiols in the presence of potassium carbonate ...
Maryna Stasevych, Viktor Zvarych, Olena Yaremkevych, Mykhaylo Vovk, Alla Vaskevych, Tetiana Halenova, Olexii Savchuk   +6 more
doaj   +3 more sources

Synthesis and Evaluation of N-(3-Trifluoroacetyl-indol-7-yl) Acetamides for Potential In Vitro Antiplasmodial Properties

Molecules, 2017
A series of novel N-((2,5-diaryl-3-trifluoroacetyl)-1H-indol-7-yl)acetamides has been prepared via a successive and one-pot reaction sequence involving initial trifluoroacetic acid-mediated Beckmann rearrangement of the oximes derived from the 1-(2,5 ...
Malose J Mphahlele, Mmakwena M Mmonwa, Yee Siew Choong   +2 more
exaly   +3 more sources

Simple preparation of new N-aryl-N-(3-indolmethyl) acetamides and their spectroscopic analysis

Universitas Scientiarum, 2009
To prepare new indolic molecules and characterize them by spectroscopic methods. Materials and methods: All reagentswere purchased from Aldrich, commercial grade.
José A. Henao, Josué S. Bello, Vladimir V. Kouznetsov, Diego F. Amado, Reinaldo Atencio   +4 more
doaj   +1 more source

Access to isoquinolin-2(1H)-yl-acetamides and isoindolin-2-yl-acetamides from a common MCR precursor [PDF]

, 2022
We achieved a divergent synthesis of isoquinolin-2(1H)-yl-acetamides (16 examples, up to 90% yields) and regioselective isoindolin-2-yl-acetamides (14 examples, up to 93% yields) in moderate to good yields by reacting various substituted ethanones or ...
Xin Li, Dömling, Alexander, Justyna Kalinowska-Tluscik, Alexander Dömling, Li, Xin, Kurpiewska, Katarzyna, Katarzyna Kurpiewska, Kalinowska-Tluscik, Justyna, Zheng, Qiang, Zheng, Qiang; id_orcid, Li, Xin; id_orcid, Wang, Qian, Kalinowska-Tłuścik, Justyna, Qian Wang, Qiang Zheng   +14 more
core   +2 more sources

Bio-Oriented Synthesis and Molecular Docking Studies of 1,2,4-Triazole Based Derivatives as Potential Anti-Cancer Agents against HepG2 Cell Line

Pharmaceuticals, 2023
Triazole-based acetamides serve as important scaffolds for various pharmacologically active drugs. In the present work, structural hybrids of 1,2,4-triazole and acetamides were furnished by chemically modifying 2-(4-isobutylphenyl) propanoic acid (1 ...
Naheed Akhter, Sidra Batool, Samreen Gul Khan, Nasir Rasool, Fozia Anjum, Azhar Rasul, Şevki Adem, Sadaf Mahmood, Aziz ur Rehman, Mehr un Nisa, Zainib Razzaq, Jørn B. Christensen, Mohammed A. S. Abourehab, Syed Adnan Ali Shah, Syahrul Imran   +14 more
doaj   +1 more source

Ultrasound Assisted Synthesis and In Silico Modelling of 1,2,4-Triazole Coupled Acetamide Derivatives of 2-(4-Isobutylphenyl)propanoic acid as Potential Anticancer Agents

Molecules, 2022
The development of an economical method for the synthesis of biologically active compounds was the major goal of this research. In the present study, we have reported the ultrasound-radiation-assisted synthesis of a series of novel N-substituted 1,2,4 ...
Sadaf Mahmood, Samreen Gul Khan, Azhar Rasul, Jørn Bolstad Christensen, Mohammed A. S. Abourehab   +4 more
doaj   +1 more source