Results 51 to 60 of about 9,081 (170)
One-pot synthesis of bicyclic sugar oxazolidinone from D-glucosamine
, 2015 Herein we report a one-pot and efficient method for the synthesis of a 1,2-cis fused furanoside bicyclic oxazolidinone derivative of D-glucosamine via pyranose to furanose conversion and concomitant cyclization involving the N-Troc group.
KULKARNI, SS, SANAPALA, SR
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, 2022 Florfenicol is widely used for the treatment of bacterial infections in domestic animals. The aim of this study was to analyze the molecular mechanisms of florfenicol and oxazolidinone resistance in Enterococcus isolates from anal feces of domestic ...
Tielun Yan (13152162) +14 more
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Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics [PDF]
, 2021 The antibiotic linezolid, the first clinically approved member of the oxazolidinone class, inhibits translation of bacterial ribosomes by binding to the peptidyl transferase center.
Stojković, Vanja +9 more
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Stereoselective syntheses of (E)-α,β-didehydroamino acid and peptide containing its residue utilizing oxazolidinone derivative [PDF]
, 2009 Reaction of methyl N-Boc-N-phenoxycarbonylglycinate with various aldehydes afforded the corresponding cis-4,5-oxazolidinone derivatives, which were effectively converted to (E)-α,β-didehydroamino acids by means of a base.
Ihara, Kohei +8 more
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Frontiers in MicrobiologyBackgroundThe emergence of optrA, which can confer resistance to phenicols and oxazolidinones in Enterococcus spp., poses a growing public health threat.Methods102 optrA-positive enterococci (OPEs) including various species were isolated from feces of ...
Yulin Fu +21 more
doaj +1 more source
Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.ABSTRACT Background Meropenem and piperacillin/tazobactam are commonly used empirical antibiotics in critically ill adults with sepsis, but whether one is superior to the other is uncertain. Methods The Empirical Meropenem versus Piperacillin/Tazobactam for Adult Patients with Sepsis (EMPRESS) trial is an ongoing investigator‐initiated, randomised ...
Nick Frørup Meier +37 more
wiley +1 more source
Wittig Rearrangements of Boron-Based Oxazolidinone Enolates
, 2019 [2,3]-Sigmatropic rearrangements (Wittig rearrangements) of α-alkoxy oxazolidinone enolates are described. Whereas alkali metal enolates fail, owing to facile deacylation, boron enolates generated from di-n-butylboron triflate and triethylamine ...
David B. Collum (1308378) +1 more
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, 2022 The use of florfenicol in farm animals may select enterococci that carry resistance genes that confer resistance to linezolid, a critically important oxazolidinone antibiotic used in human medicine.
Treier, Andrea +5 more
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Clinical and Translational ScienceThe objective of this study was to develop a population pharmacokinetic model for linezolid in hematooncological patients with sepsis, and to propose dosing optimization based on pharmacokinetic covariates that would lead to improved achievement of the ...
Alžběta Zavřelová +9 more
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Crystal structure of (S)-5-(3-acetyl-5-chloro-2-ethoxy-6-fluorophenyl)-2-oxazolidinone
Acta Crystallographica Section E: Crystallographic CommunicationsThe structure of (S)-5-(3-acetyl-5-chloro-2-ethoxy-6-fluorophenyl)-2-oxazolidinone, C13H13ClFNO4, at 100 K has monoclinic (P21) symmetry. The compound has a polymeric structure propagated by a screw axis parallel to the b axis with N—H...O hydrogen ...
Victor Li, Glenn P. A. Yap, Chaoying Ni
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