Results 51 to 60 of about 6,207 (176)

Linezolid‐induced lactic acidosis in critically ill patients: A multicentre study of incidence, severity and predictors

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2239-2249, July 2026.
Abstract Introduction Linezolid, a synthetic oxazolidinone for resistant gram‐positive infections, is generally associated with mild adverse effects such as gastrointestinal disturbances, but more serious reactions like lactic acidosis (LA) have also been reported.
Lina Naseralallah, Bodoor Aboujabal, Zahra Noureddine, Khaled Aboujabal, Somaya Koraysh   +4 more
wiley   +1 more source

Management of Traumatic Penile Degloving Injury in a Resource‐Constrained Setting: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Genital degloving injuries from motorcycle accidents are uncommon, with most reported cases involving complete devascularisation requiring skin grafting. We present a 70‐year‐old male who presented to a rural health center following a high‐speed motorcycle accident with a unique distal pedicure circumferential penile skin avulsion.
Shehdev Meghwar, Umaya Memon, Vishan Das, Shankar Meghwar, Dhivya Bharathi, Siddhant Kumar Yadav   +5 more
wiley   +1 more source

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

Microwave-Assisted Condensation of Two Potential Antibacterial Pharmacophores (Sulfonamide and Oxazolidinone)

Engineering Proceedings
In recent years, microwave heating has become a widely used technique in organic synthesis. The reactions take place within a very short time, under mild conditions with high yields, and produce pure and selective compounds with fewer side reactions.
Radia Bouasla, Malika Berredjem
doaj   +1 more source

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1845-1856, June 2026.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

The Effectiveness of Linezolid and Teicoplanin for Managing Infections After Burn Injuries: A Retrospective Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Gram‐positive infections in burn patients present significant treatment challenges. This study compared the efficacy and safety of linezolid vs. teicoplanin for managing such infections in a clinical setting. Methods We conducted a retrospective study involving 77 burn patients with confirmed Gram‐positive infections at ...
Abolfazl Zendehdel, Maryam Roham, Sanam Soltani, Amirali Jahanshahi, Somayeh Heidarizadi   +4 more
wiley   +1 more source

In vitro Susceptibility of Nontuberculous Mycobacteria to Tedizolid

Infection and Drug Resistance, 2022
Huiyun Zhang,1 Wenya Hua,1 Siran Lin,1 Yu Zhang,1 Xinchang Chen,1 Shiyong Wang,1 Jiazhen Chen,1 Wenhong Zhang1– 3 1Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center
Zhang H, Hua W, Lin S, Zhang Y, Chen X, Wang S, Chen J, Zhang W   +7 more
doaj  

An Efficient Approach to the Synthesis of Novel Oxazolidinones as Potential Antimicrobial Agents

Journal of Chemistry, 2013
Oxazolidinone, either mononuclear or condensed with other heterocyclics, has established its importance in medicinal chemistry. A variety of biological activities have been reported by oxazolidinone derivatives.
Kavita Devi, Yumna Asmat, Sonika Jain, Swapnil Sharma, Jaya Dwivedi   +4 more
doaj   +1 more source

Current Problems of Infections Caused by MRSA and Ways to Address Them

Антибиотики и Химиотерапия, 2020
The increase in the growth rate of MRSA as an etiologic factor has been recorded worldwide in recent years. The main problem of antibiotic resistance in Staphylococcus aureus is its resistance to beta-lactam antibiotics.
S. K. Zyryanov, I. N. Sychev, Yu. Sh. Gushchina   +2 more
doaj