Results 1 to 10 of about 2,970 (183)

Intracellular Accumulation of Linezolid and Florfenicol in OptrA-Producing Enterococcus faecalis and Staphylococcus aureus [PDF]

Molecules, 2018
The optrA gene, which confers transferable resistance to oxazolidinones and phenicols, is defined as an ATP-binding cassette (ABC) transporter but lacks transmembrane domains. The resistance mechanism of optrA and whether it involves antibiotic efflux or
Yingyu Wang, Xiaowei Li, Yang Wang, Stefan Schwarz, Jianzhong Shen, Xi Xia   +5 more
doaj   +7 more sources

High prevalence and plasmidome diversity of optrA-positive enterococci in a Shenzhen community, China. [PDF]

Front Microbiol
BackgroundThe emergence of optrA, which can confer resistance to phenicols and oxazolidinones in Enterococcus spp., poses a growing public health threat.Methods102 optrA-positive enterococci (OPEs) including various species were isolated from feces of ...
Fu Y, Deng Z, Shen Y, Wei W, Xiang Q, Liu Z, Hanf K, Huang S, Lv Z, Cao T, Peng C, Zhang R, Zou X, Shen J, Schwarz S, Wang Y, Liu D, Lv Z, Ke Y.   +18 more
europepmc   +5 more sources

Emergence of Linezolid Resistance Genes <i>optrA</i> and <i>cfr</i>(D) in an <i>Enterococcus saccharolyticus</i> from Chicken. [PDF]

Antibiotics (Basel)
Background: The emergence of linezolid resistance, mediated by genes such as optrA and cfr(D), poses a growing public health threat. While these genes have been detected in clinical and animal-derived Enterococcus species, their presence in underexplored
Gao X, Luo X, Qian R, Gao G, Liu J, Hong J, Yue C, Liu JH, Liu YY.   +8 more
europepmc   +4 more sources

Prevalence and genetic diversity of optrA-positive enterococci isolated from patients in an anorectal surgery ward of a Chinese hospital. [PDF]

Front Microbiol
Linezolid-resistant enterococci have increased in recent years due to the worldwide spread of acquired resistance genes (cfr, optrA, and poxtA) in clinical, animal, and environmental settings.
Li Y, Jiang T, Mao J, Xu F, Zhang R, Yan J, Cai J, Xie Y.   +7 more
europepmc   +2 more sources

Molecular Epidemiology and Genetic Context of <i>optrA</i>-Carrying Linezolid-Resistant Enterococci from Humans and Animals in South Korea. [PDF]

Antibiotics (Basel)
Objectives: Linezolid resistance among Enterococcus species poses a growing clinical and public health concern, especially due to the dissemination of transferable resistance genes, such as optrA.
On Y, Lee SY, Yoo JS, Kim JW.
europepmc   +2 more sources

Analysis of two pheromone-responsive conjugative multiresistance plasmids carrying the novel mobile optrA locus from Enterococcus faecalis [PDF]

Infection and Drug Resistance, 2019
Yanhong Shang,1,2,* Dexi Li,2,* Xinxin Shan,2 Stefan Schwarz,3 Su-Mei Zhang,2 Yu-Xia Chen,2 Wuqing Ouyang,1 Xiang-Dang Du21Department of Basic Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Shaanxi 712100, People’
Shang Y, Li D, Shan X, Schwarz S, Zhang SM, Chen YX, Ouyang W, Du XD   +7 more
doaj   +3 more sources

Genomic analysis of Enterococcus faecium co-carrying optrA and poxtA from a swine farm: dissemination across the human-animal-environment interface. [PDF]

BMC Microbiol
Background The transferable resistance genes optrA and poxtA mediate cross-resistance to florfenicol and linezolid, posing serious challenges to both veterinary and human healthcare. Swine farms serve as critical ecological niches for the development and
Xia P, Wu H, Chen W, Tian R, Yang M, Xu S, Zhang C, Zeng T, Xia L.   +8 more
europepmc   +2 more sources

The prevalence of optrA-carrying Enterococci in the vaginal micro-ecology of pregnant women in late pregnancy. [PDF]

Microbiol Spectr
The colonization of Enterococcus in the female vagina leads to neonatal and pediatric enterococcal septicemia. Linezolid (LZD) is a kind of mainstream drug for treating multidrug-resistant Gram-positive infections.
Xie Y, Xu F, Dong H, Mao J, Zhang C.
europepmc   +2 more sources

Prevalence and genetic characterization of Gram-positive bacteria carrying linezolid resistance genes in vegetables. [PDF]

Environ Microbiome
Background Linezolid resistance poses an ecological threat to the health of humans, animals, and the environment. Vegetable may serve as reservoirs for resistance genes, yet its prevalence remain underexplored.
Xu Y, Shen W, Zeng K, Zhang R, Cai J.
europepmc   +2 more sources

Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China. [PDF]

BMC Infect Dis
Background Immunocompromised cancer patients represent a susceptible population for enterococcal infections. While linezolid remains the primary therapeutic option for vancomycin-resistant Enterococcus (VRE) infections, the emergence of linezolid ...
Wang Q, Zhang X, Wu W, Xie Z, Lin Y, Zhang L.   +5 more
europepmc   +2 more sources