Genomic analysis of Enterococcus faecium co-carrying optrA and poxtA from a swine farm: dissemination across the human–animal–environment interface [PDF]
BMC MicrobiologyBackground The transferable resistance genes optrA and poxtA mediate cross-resistance to florfenicol and linezolid, posing serious challenges to both veterinary and human healthcare. Swine farms serve as critical ecological niches for the development and
Lining Xia, Shuqin Xu
exaly +6 more sources
Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics [PDF]
Nature Communications, 2022 PoxtA confers resistance to ribosome-targeting oxazolidinone (linezolid) and chloramphenicol antibiotics. Here, Crowe-McAuliffe et al. provide structural insights into how binding of PoxtA to the ribosome indirectly promotes drug dissociation.
Lilit Nersisyan +2 more
exaly +9 more sources
Microbiology Spectrum, 2022 Linezolid plays a crucial role in the treatment of infections caused by multiresistant Gram-positive bacteria. The poxtA gene not only confers oxazolidinone and phenicol resistance but also decreases susceptibility to tetracycline.
Xiang-Dang Du, Xinxin Shan
exaly +6 more sources
Frontiers in Sustainable Food Systems, 2023 IntroductionThe presence of linezolid-resistant enterococci found in animal-derived food has attracted attention for possible transmission to human-derived enterococci through the food chain.
Biao Tang, Min Yue, Yangying Sun
exaly +4 more sources
Linezolid-resistant Enterococcus faecium clinical isolates from Pakistan: a genomic analysis [PDF]
BMC MicrobiologyBackground Linezolid-resistant Enterococcus faecium (LRE) is a global priority pathogen. Thirteen LRE were reported from clinical specimens between November 2021 and April 2023 at two laboratories in Karachi, Pakistan.
Syed Ali Raza Nasir +16 more
doaj +3 more sources
Genomic insights into the global dissemination of linezolid resistance genes in Enterococcus faecium [PDF]
Frontiers in MicrobiologyBackgroundTransferable linezolid resistance determinants in Enterococcus faecium, particularly optrA, poxtA, and cfr, have raised increasing global concern due to their potential dissemination across clinical, animal, food, and environmental reservoirs ...
Xiaoxiao Yuan +6 more
doaj +2 more sources
Spread of oxazolidinone-resistant enterococci in an Italian pig slaughterhouse [PDF]
Frontiers in MicrobiologyThe swine production chain represents a critical point for the spread of antimicrobial resistance, with slaughterhouses acting as potential hotspots for cross-contamination. The veterinary use of phenicols may promote resistance to oxazolidinones, a last-
Francesca Romana Massacci +15 more
doaj +2 more sources
Anaerobic bacteria: a neglected reservoir of mobile oxazolidinone resistance genes [PDF]
Gut MicrobesOxazolidinones are critical last-resort antimicrobials against severe infections caused by Gram-positive bacteria, whereas mobile oxazolidinone resistance genes (MORGs, including cfr, optrA, poxtA) severely compromise their clinical efficacy.
Simeng Liu +7 more
doaj +2 more sources
A multiplex PCR for rapid detection of vancomycin and linezolid resistance genes in clinical and environmental enterococci: A one health diagnostic approach [PDF]
One HealthBackground: Antimicrobial resistance (AMR) in Enterococcus, particularly vancomycin-resistance (VRE) and linezolid-resistance (LZRE) strains, presents a rising threat to public health globally.
Yusuf Wada +14 more
doaj +2 more sources
Prevalence and genetic diversity of optrA-positive enterococci isolated from patients in an anorectal surgery ward of a Chinese hospital [PDF]
Frontiers in MicrobiologyLinezolid-resistant enterococci have increased in recent years due to the worldwide spread of acquired resistance genes (cfr, optrA, and poxtA) in clinical, animal, and environmental settings.
Yuanyuan Li +7 more
doaj +2 more sources