Results 11 to 20 of about 832 (175)
Characterization of a novel cfr(D)/poxtA-carrying plasmid in an oxazolidinone-resistant Enterococcus casseliflavus isolate from swine manure, Italy [PDF]
Journal of Global Antimicrobial Resistance, 2022 Marzia Cinthi +8 more
doaj +5 more sources
Frontiers in Sustainable Food Systems, 2023 IntroductionThe presence of linezolid-resistant enterococci found in animal-derived food has attracted attention for possible transmission to human-derived enterococci through the food chain.
Juan Ni +11 more
doaj +2 more sources
Microbiology Spectrum, 2022 Linezolid plays a crucial role in the treatment of infections caused by multiresistant Gram-positive bacteria. The poxtA gene not only confers oxazolidinone and phenicol resistance but also decreases susceptibility to tetracycline.
Xinxin Shan +5 more
doaj +4 more sources
Structural basis for PoxtA-mediated resistance to phenicol and oxazolidinone antibiotics
Nature Communications, 2022 PoxtA confers resistance to ribosome-targeting oxazolidinone (linezolid) and chloramphenicol antibiotics. Here, Crowe-McAuliffe et al. provide structural insights into how binding of PoxtA to the ribosome indirectly promotes drug dissociation.
Caillan Crowe-McAuliffe +12 more
doaj +7 more sources
Genetic Characterization of a Linezolid- and Penicillin-Resistant <i>Enterococcus hirae</i> Isolate Co-Harboring <i>poxtA</i> and <i>pbp5fm</i>. [PDF]
Transbound Emerg DisLinezolid and penicillin are critical for treating multidrug resistant (MDR) Gram‐positive infections, but the emergence of resistance to both seriously threatens public health. Here, we first report the cocarrying poxtA (oxazolidinone resistance) and pbp5fm (β‐lactam resistance) genes by the plasmid in a strain of Enterococcus hirae HDC14‐2 derived ...
Huang J +6 more
europepmc +3 more sources
Antibiotics, 2022 Oxazolidinones are valuable antimicrobials that are used to treat severe infections due to multidrug-resistant (MDR) Gram-positive bacteria. However, in recent years, a significant spread of clinically relevant linezolid-resistant human bacteria that is ...
Marzia Cinthi +5 more
doaj +3 more sources
Identification of the Multiresistance Gene poxtA in Oxazolidinone-Susceptible Staphylococcus haemolyticus and Staphylococcus saprophyticus of Pig and Feed Origins [PDF]
Pathogens, 2021 Previous studies on the prevalence and transmission mechanism of oxazolidinone resistance gene poxtA in CoNS are lacking, which this study addresses. By screening 763 CoNS isolates from different sources of several livestock farms in Guangdong, China ...
Lin Chen +7 more
doaj +3 more sources
Journal of Global Antimicrobial ResistanceObjectives: The poxtA gene is a transferable linezolid-resistance gene that encodes an ATP-binding cassette F protein that prevents linezolid from inhibiting protein synthesis.
Fernando Lázaro-Perona +8 more
doaj +4 more sources
MicrobiologyOpen, 2023 Identifying antimicrobial resistance (AMR) genes and determining their occurrence in Gram‐positive bacteria provide useful data to understand how resistance can be acquired and maintained in these bacteria.
Carole Kowalewicz +4 more
doaj +2 more sources
Detection of the Phenicol–Oxazolidinone Resistance Gene poxtA in Enterococcus faecium and Enterococcus faecalis from Food-Producing Animals during 2008–2018 in Korea [PDF]
Microorganisms, 2020 We aimed to investigate the presence of the phenicol–oxazolidinone resistance gene poxtA in linezolid-resistant enterococci from food-producing animals and analyze its molecular characteristics. We collected 3941 Enterococcus faecium and 5088 E. faecalis
Seok-Hyeon Na +8 more
doaj +3 more sources