Results 1 to 10 of about 2,219,397 (166)

Ribosomal protection as a linezolid resistance mechanism in Mycobacterium abscessus [PDF]

Antimicrobial Agents and Chemotherapy
Mycobacterium abscessus has emerged as a significant pulmonary pathogen characterized by its resistance to most first-line antimycobacterial drugs. Recent investigations have highlighted the clinical efficacy of including the oxazolidinone antibiotic ...
Tobias Funck, Kerry McGowen, Mark R. Sullivan, Samuel Zinga, Ian D. Wolf, Dennis Nurjadi, Claudia M. Denkinger, Eric J. Rubin   +7 more
doaj   +2 more sources

Prevalence and genetic characterization of Gram-positive bacteria carrying linezolid resistance genes in vegetables [PDF]

Environmental Microbiome
Background Linezolid resistance poses an ecological threat to the health of humans, animals, and the environment. Vegetable may serve as reservoirs for resistance genes, yet its prevalence remain underexplored.
Yinglin Xu, Weiyi Shen, Kaiqi Zeng, Rong Zhang, Jiachang Cai   +4 more
doaj   +2 more sources

Acquired linezolid resistance in DR-TB: genotype-phenotype discordance and molecular heterogeneity in a retrospective cohort [PDF]

BMC Infectious Diseases
Background Linezolid is an important drug for the treatment of drug-resistant tuberculosis (DR-TB). Acquired linezolid resistance threatens treatment efficacy.
Wenqiang Zhou, Qingfeng Wang, Wenjuan Nie, Wenhui Shi, Yang Yang, Wenjie Qi, Yu Lu, Naihui Chu   +7 more
doaj   +2 more sources

Low Proportion of Linezolid and Daptomycin Resistance Among Bloodborne Vancomycin-Resistant Enterococcus faecium and Methicillin-Resistant Staphylococcus aureus Infections in Europe

Frontiers in Microbiology, 2021
Vancomycin-resistant Enterococcus faecium (VREF) and methicillin-resistant Staphylococcus aureus (MRSA) are associated with significant health burden. We investigated linezolid and daptomycin resistance among VREF and MRSA in the EU/EEA between 2014 and ...
Robby Markwart, Niklas Willrich, Tim Eckmanns, Guido Werner, Olaniyi Ayobami   +4 more
doaj   +3 more sources

Plasmid-Coded Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus from Food and Livestock in Germany [PDF]

Antibiotics, 2022
Resistance of methicillin-resistant Staphylococcus aureus (MRSA) from food and livestock to last resort antibiotics such as linezolid is highly concerning, since treatment options for infections in humans might be diminished.
Tobias Lienen, Mirjam Grobbel, Bernd-Alois Tenhagen, Sven Maurischat   +3 more
doaj   +2 more sources

Clinical features associated with linezolid resistance among multidrug resistant tuberculosis patients at a tertiary care hospital in Mumbai, India

Journal of Clinical Tuberculosis and Other Mycobacterial Diseases, 2020
Background: Multidrug-resistant tuberculosis (MDR-TB) is an increasing problem worldwide, and 24% occurs in India. Linezolid is associated with improved MDR-TB treatment outcomes but causes significant side-effects and drug susceptibility testing (DST ...
J.A. Tornheim, E. Intini, A. Gupta, Z.F. Udwadia   +3 more
doaj   +3 more sources

Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China [PDF]

BMC Infectious Diseases
Background Immunocompromised cancer patients represent a susceptible population for enterococcal infections. While linezolid remains the primary therapeutic option for vancomycin-resistant Enterococcus (VRE) infections, the emergence of linezolid ...
Qun Wang, Xiaoyu Zhang, Weixing Wu, Zhenghua Xie, Yongping Lin, Li Zhang   +5 more
doaj   +2 more sources

First Case of Staphylococci Carrying Linezolid Resistance Genes from Laryngological Infections in Poland [PDF]

Pathogens, 2021
Linezolid is currently used to treat infections caused by multidrug-resistant Gram-positive cocci. Both linezolid-resistant S. aureus (LRSA) and coagulase-negative staphylococci (CoNS) strains have been collected worldwide.
Michał Michalik, Maja Kosecka-Strojek, Mariola Wolska, Alfred Samet, Adrianna Podbielska-Kubera, Jacek Międzobrodzki   +5 more
doaj   +2 more sources

Sentinel Surveillance Reveals Emerging Daptomycin-Resistant ST736 Enterococcus faecium and Multiple Mechanisms of Linezolid Resistance in Enterococci in the United States [PDF]

Frontiers in Microbiology, 2022
Enterococcus faecalis and faecium with resistance to daptomycin and/or linezolid are emerging globally. We present the genomic characterization of daptomycin- and linezolid-resistant E. faecalis and E. faecium surveillance isolates from the United States,
Amy S. Gargis, Lori M. Spicer, Lori M. Spicer, Alyssa G. Kent, Alyssa G. Kent, Wenming Zhu, Davina Campbell, Gillian McAllister, Thomas O. Ewing, Thomas O. Ewing, Valerie Albrecht, Valerie A. Stevens, Mili Sheth, Jasmine Padilla, Jasmine Padilla, Dhwani Batra, J. Kristie Johnson, Alison Laufer Halpin, J. Kamile Rasheed, Christopher A. Elkins, Maria Karlsson, Joseph D. Lutgring   +21 more
doaj   +2 more sources

Mapping the widespread distribution and transmission dynamics of linezolid resistance in humans, animals, and the environment [PDF]

Microbiome
Background The rise of linezolid resistance has been widely observed both in clinical and non-clinical settings. However, there were still data gaps regarding the comprehensive prevalence and interconnections of linezolid resistance genes across various ...
Weiyi Shen, Chang Cai, Ning Dong, Jiawei Chen, Rong Zhang, Jiachang Cai   +5 more
doaj   +2 more sources