Results 31 to 40 of about 2,219,397 (166)

Linezolid Resistance Genes and Mutations among Linezolid-Susceptible Enterococcus spp.-A Loose Cannon? [PDF]

Antibiotics (Basel)
The National Reference Centre for Enterococci receives an increasing number of linezolid-resistant Enterococcus isolates. Linezolid (LIN) resistance is mediated by G2576T 23S rDNA gene mutations and/or acquisition of resistance genes (cfr, optrA, poxtA).
Bender JK, Fleige C, Funk F, Moretó-Castellsagué C, Fischer MA, Werner G.   +5 more
europepmc   +2 more sources

Synergistic Combination of Linezolid and Fosfomycin Closing Each Other’s Mutant Selection Window to Prevent Enterococcal Resistance

Frontiers in Microbiology, 2021
Enterococci, the main pathogens associated with nosocomial infections, are resistant to many common antibacterial drugs including β-lactams, aminoglycosides, etc.
Lifang Jiang, Lifang Jiang, Na Xie, Na Xie, Mingtao Chen, Mingtao Chen, Yanyan Liu, Shuaishuai Wang, Shuaishuai Wang, Jun Mao, Jun Mao, Jiabin Li, Xiaohui Huang, Xiaohui Huang   +13 more
doaj   +1 more source

Resistance to Linezolid [PDF]

, 2017
Linezolid is an antimicrobial agent that binds to the bacterial ribosomeand thereby inhibits protein synthesis. Soon after its release as aclinical drug, it became clear that bacteria could become resistant tolinezolid.
Birte Vester, Ntokou, Eleni, Eleni Ntokou, Vester, Birte   +3 more
core   +1 more source

Immunomodulatory Effect of Linezolid on Methicillin-Resistant Staphylococcus aureus Supernatant-Induced MUC5AC Overexpression in Human Airway Epithelial Cells [PDF]

, 2014
Linezolid is the first member of the oxazolidinones and is active against drug-resistant Gram-positive pathogens, such as methi-cillin- resistant Staphylococcus aureus (MRSA).
賀来, 敬仁, Yamada, Koichi, Yanagihara, Katsunori, Nagaoka, Kentaro, Kohno, Shigeru, Nakamura, Shigeki, Izumikawa, Koichi, Kaku, Norihito, Migiyama, Yohei, Morinaga, Yoshitomo, Harada, Yosuke   +10 more
core   +1 more source

Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome

mBio, 2017
An unorthodox, surprising mechanism of resistance to the antibiotic linezolid was revealed by cryo-electron microscopy (cryo-EM) in the 70S ribosomes from a clinical isolate of Staphylococcus aureus.
Matthew J. Belousoff, Zohar Eyal, Mazdak Radjainia, Tofayel Ahmed, Rebecca S. Bamert, Donna Matzov, Anat Bashan, Ella Zimmerman, Satabdi Mishra, David Cameron, Hans Elmlund, Anton Y. Peleg, Shashi Bhushan, Trevor Lithgow, Ada Yonath   +14 more
doaj   +1 more source

Phenotypic Investigation of Vancomycin, Teicoplanin and Linezolid Resistance Among Enterococcus spp. Isolated from Children Diarrhea

, 2019
Vancomycin-resistant Enterococci(VRE) were common among Enterococcus. faecalis and Enterococcus faecium. Teicoplanin resistance or sensitivity can determine the VRE phenotypes whether VanA (VanR/TecR) or VanB (VanR/TecS). Linezolid resistance among VRE
Mohammed Sh. Jebur, Anwar M. Lazm, Hussein W. S. Rabeea, Mohammed H. Al-Allak, Ali Saleem Abdulridha Aridhee, Noor S. K. Al-Khafaji, Hussein O. M. Al-Dahmoshi   +6 more
core   +1 more source

Can We Prevent Antimicrobial Resistance by Using Antimicrobials Better? [PDF]

, 2013
Since their development over 60 years ago, antimicrobials have become an integral part of healthcare practice worldwide. Recently, this has been put in jeopardy by the emergence of widespread antimicrobial resistance, which is one of the major problems ...
Germander Soothill, Hu, Y, Yanmin Hu, Soothill, G, Anthony Coates, Coates, A   +5 more
core   +1 more source

Evolution of Antibiotic Resistance of Coagulase-Negative Staphylococci Isolated from Healthy Turkeys in Egypt: First Report of Linezolid Resistance [PDF]

, 2019
Coagulase-negative staphylococci (CoNS) are gaining much attention as causative agents of serious nosocomial infections in humans. This study aimed to determine the prevalence and phenotypic antimicrobial resistance of CoNS as well as the presence of ...
Helmut Hotzel, Roesler, Uwe, Hosny El-Adawy, Awad, Omnia, Hafez, Hafez M., Neubauer, Heinrich Karl Johann, Hafez M. Hafez, Moawad, Amira, Herbert Tomaso, Omnia Awad, Heinrich Neubauer, Tomaso, Herbert, Uwe Roesler, El-Adawy, Hosny Hassan Hosny, Amira A. Moawad, Hotzel, Helmut   +15 more
core   +1 more source

Linezolid use in German acute care hospitals: results from two consecutive national point prevalence surveys

Antimicrobial Resistance and Infection Control, 2019
Background Linezolid belongs to a reserve group of antibiotics. In recent years, reports on linezolid resistance in gram-positive cocci have become more frequent. Overuse of linezolid is a relevant factor for resistance development. The objective of this
Tobias Siegfried Kramer, Frank Schwab, Michael Behnke, Sonja Hansen, Petra Gastmeier, Seven Johannes Sam Aghdassi   +5 more
doaj   +1 more source

Characteristics of linezolid-resistant Enterococcus faecalis isolates from broiler breeder farms

Poultry Science, 2020
Linezolid is an oxazolidinone class antibiotic used for treatment infections caused by various multidrug-resistant gram-positive pathogens including enterococci.
Sunghyun Yoon, Yeong Bin Kim, Kwang Won Seo, Jong Su Ha, Eun Bi Noh, Young Ju Lee   +5 more
doaj   +1 more source