Results 41 to 50 of about 2,219,397 (166)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Compassionate Use of Linezolid for Adult Taiwanese Patients with Bone and Joint Infections

, 2011
Compassionate use of linezolid for bone and joint infections has been reported and hematological adverse reactions are a cause for concern. A similar experience in Asian people has not been reported.
LU, PO-LIANG;WANG, JANN-TAY;CHEN, CHI-LONG;CHEN, WAN-CHIN;CHEN, TUN-CHIEH;HUANG, YHU-CHERING;CHANG, SHAN-CHWEN, 盧柏樑;王振泰;陳志榮;陳婉青;陳惇杰;黃玉成;張上淳   +1 more
core   +1 more source

A case series of necrotizing periodontal diseases in hospitalized patients: What hasn't been said yet?

Clinical Advances in Periodontics, EarlyView.
Abstract Background Necrotizing periodontal diseases (NPDs) are uncommon and severe inflammatory conditions characterized by tissue necrosis, painful ulceration, and rapid clinical progression, frequently associated with systemic immunosuppression. Limited data exist regarding their clinical presentation and management in hospital settings.
Osmaria Letthycia Carvalho Leal, Fernanda Bortolotto, Mariana Cristina Manoel, Gabriela Silveira de Araújo, Ana Carolina Fragoso Motta, Leandro Dorigan de Macedo, Lara Maria Alencar Ramos Innocentini, Joab Cabral Ramos, Isabel Schausltz Pereira Faustino   +8 more
wiley   +1 more source

Challenges for interpreting results of antimicrobial susceptibility testing for treating infections of foals with Rhodococcus equi

Equine Veterinary Journal, EarlyView.
Abstract Rhodococcus equi is a facultative intracellular pathogen and a major cause of pneumonia in foals worldwide. The standard treatment for affected foals is a combination of a macrolide with rifampicin. The widespread use of this combination has led to the emergence of multidrug‐resistant (MDR) strains of R. equi.
Marlane Geribone Seeger, Letícia Trevisan Gressler, Laura Huber, Sonsiray Alvarez‐Narvaez, Juliana Felipetto Cargnelutti, Angela Ilha Bordin, Sara D. Lawhon, Noah D. Cohen   +7 more
wiley   +1 more source

The Global Prevalence of Daptomycin, Tigecycline, and Linezolid-Resistant Enterococcus faecalis and Enterococcus faecium Strains From Human Clinical Samples: A Systematic Review and Meta-Analysis

Frontiers in Medicine, 2021
Background and Aim: The predominant species of the Enterococcus, Enterococcus faecalis (E. faecalis) and Enterococcus faecium (E. faecium) cause great variety of infections.
Masoud Dadashi, Masoud Dadashi, Parastoo Sharifian, Nazila Bostanshirin, Bahareh Hajikhani, Narjess Bostanghadiri, Nafiseh Khosravi-Dehaghi, Nafiseh Khosravi-Dehaghi, Alex van Belkum, Davood Darban-Sarokhalil   +9 more
doaj   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Prevalence and Genetic Analysis of Resistance Mechanisms of Linezolid-Nonsusceptible Enterococci in a Tertiary Care Hospital Examined via Whole-Genome Sequencing

, 2022
(1) Background: Linezolid plays an important role in the treatment of invasive infections caused by vancomycin-resistant enterococci after its introduction to clinical practice.
Kyungwon Lee, Le Phuong Nguyen, Lee, Kyungwon, Hyukmin Lee, Seo, Younghee, Yong, Dongeun, Nguyen, Le Phuong, Yuxin Hu, Kennedy Mensah Osei, Osei, Kennedy Mensah, Lee, Yoonhee, Choi, Jong Rak, Kim, Junglim, Junglim Kim, Younghee Seo, Hu, Yuxin, Lee, Hyukmin, Won, Dongju, Dongju Won, Yoonhee Lee, Dongeun Yong, Jong Rak Choi   +21 more
core   +1 more source

Cfr Gene-based Detection of Linezolid-Resistant Staphylococcus Aureus in a Tertiary Care Hospital in Western Uttar Pradesh, India

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Objective Linezolid is an important antimicrobial agent which is active against multidrug-resistant Gram-positive cocci. Methicillin-resistant Staphylococcus aureus (MRSA) cause life-threatening infection, with narrow therapeutic options including ...
Km. Sangita, Anita Pandey, Geeta Gupta, Ankita Gupta   +3 more
doaj   +1 more source

Rapid Acquisition of Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus: Role of Hypermutation and Homologous Recombination.

PLoS ONE, 2016
BackgroundWe previously reported the case of a 64-year-old man with mediastinitis caused by Staphylococcus aureus in which the infecting bacterium acquired linezolid resistance after only 14 days treatment with linezolid.
Shigekazu Iguchi, Tomonori Mizutani, Keiichi Hiramatsu, Ken Kikuchi   +3 more
doaj   +1 more source

Sodium Diclofenac‐Loaded Drug Delivery Microspheres: Impact on Calcium Hydroxide Paste Properties and Biological Response

Australian Endodontic Journal, EarlyView.
ABSTRACT This study evaluated whether the incorporation of sodium diclofenac‐loaded microspheres into a calcium hydroxide paste enhances antibiofilm activity while maintaining physicochemical properties and biocompatibility. Calcium hydroxide paste, calcium hydroxide combined with sodium diclofenac, and calcium hydroxide containing sodium diclofenac ...
João Vitor Oliveira de Amorim, Murilo Priori Alcalde, Leonardo Cabau, Rodrigo Ricci Vivan, Paulo Henrique Weckwerth, Marco Antonio Hungaro Duarte, Guilherme Ferreira da Silva   +6 more
wiley   +1 more source