Linezolid for drug-resistant tuberculosis [PDF]
Cochrane Database of Systematic Reviews, 2017 This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:\ud \ud To assess the efficacy of linezolid when used as part of a second-line regimen for treating people with multidrug-resistant (MDR-) and extensively drug-resistant (XDR-) pulmonary tuberculosis (TB), and to assess the prevalence and severity of adverse events ...
Singh, Bhagteshwar +3 more
openaire +3 more sources
Linezolid Resistance Genes and Mutations among Linezolid-Susceptible Enterococcus spp.-A Loose Cannon? [PDF]
Antibiotics (Basel)The National Reference Centre for Enterococci receives an increasing number of linezolid-resistant Enterococcus isolates. Linezolid (LIN) resistance is mediated by G2576T 23S rDNA gene mutations and/or acquisition of resistance genes (cfr, optrA, poxtA). There are anecdotal reports that those resistance traits may be present in phenotypically linezolid-
Bender JK +5 more
europepmc +5 more sources
When good bugs go bad: Epidemiology and antimicrobial resistance profiles of Corynebacterium striatum, an emerging multidrug-resistant, opportunistic pathogen [PDF]
, 2017 Infections with Corynebacterium striatum have been described in the literature over the last 2 decades, with the majority being bacteremia, central line infections, and occasionally, endocarditis.
Anderson, Neil +4 more
core +2 more sources
Structural Basis for Linezolid Binding Site Rearrangement in the
mBio, 2017 An unorthodox, surprising mechanism of resistance to the antibiotic linezolid was revealed by cryo-electron microscopy (cryo-EM) in the 70S ribosomes from a clinical isolate of Staphylococcus aureus.
Matthew J. Belousoff +14 more
doaj +1 more source
Resistance to Linezolid Caused by Modifications at Its Binding Site on the Ribosome [PDF]
, 2012 Linezolid is an oxazolidinone antibiotic in clinical use for the treatment of serious infections of resistant Gram-positive bacteria. It inhibits protein synthesis by binding to the peptidyl transferase center on the ribosome. Almost all known resistance
Long, Katherine S., Vester, Birte
core +1 more source
Synergy of Linezolid with Several Antimicrobial Agents against Linezolid-Methicillin-Resistant Staphylococcal Strains [PDF]
Antibiotics, 2020 Linezolid is a synthetic oxazolydinone active against multi-resistant Gram-positive cocci that inhibits proteins synthesis by interacting with the 50S ribosomal subunit. Although linezolid-resistant strains are infrequent, several outbreaks have been recently described, associated with prolonged treatment with the antibiotic.
Valderrama, María-José +5 more
openaire +3 more sources
Identification of New Drug Candidates Against \u3cem\u3eBorrelia burgdorferi\u3c/em\u3e Using High-Throughput Screening [PDF]
, 2016 Lyme disease is the most common zoonotic bacterial disease in North America. It is estimated that .300,000 cases per annum are reported in USA alone. A total of 10%–20% of patients who have been treated with antibiotic therapy report the recrudescence of
Babar, Mustafeez Mujtaba +9 more
core +3 more sources
Reduced biofilm production associated with increasing linezolid MICs among linezolid-resistant staphylococci [PDF]
Journal of Antimicrobial Chemotherapy, 2009 Sir, To follow-up our previous finding of reduced polystyrene adherence accompanying the acquisition of linezolid resistance in a clinical bloodstream isolate of methicillin-resistant Staphylococcus aureus (MRSA), we evaluated the polystyrene adherence properties of linezolid-resistant staphylococci obtained from our institution as well as isolates ...
Patricia, Dandache +4 more
openaire +2 more sources
Molecules, 2023 AbstractEnterococci resistance is increasing sharply, which poses a serious threat to public health. Rhamnolipids are a kind of amphiphilic compound used for its bioactivities, while the combination of nontraditional drugs to restore linezolid activity is an attractive strategy to treat infections caused by these pathogens.
Qingru Chang +8 more
openaire +3 more sources
Successful ceftolozane/tazobactam treatment of chronic pulmonary infection with pan‐resistant Pseudomonas aeruginosa [PDF]
, 2015 The treatment of chronic Pseudomonas aeruginosa infections is challenging, with resistance and antibiogram diversity accumulating during successive therapies.
Andrews +9 more
core +1 more source