Results 11 to 20 of about 41,061 (224)
Linezolid Resistance in Staphylococci [PDF]
Pharmaceuticals, 2010 Linezolid, the first oxazolidinone to be used clinically, is effective in the treatment of infections caused by various Gram-positive pathogens, including multidrug resistant enterococci and methicillin-resistant Staphylococus aureus.
Stefania Stefani +3 more
doaj +4 more sources
Genomic epidemiology reveals multiple mechanisms of linezolid resistance in clinical enterococci in China [PDF]
Annals of Clinical Microbiology and AntimicrobialsBackground Infections caused by linezolid-resistant enterococci (LRE) are clinically difficult to treat and threaten patient health. However, there is a lack of studies on long time-span LRE strains in China.
Ziran Wang +9 more
doaj +2 more sources
Mechanisms of Linezolid Resistance in Mycobacteria. [PDF]
Pharmaceuticals (Basel), 2023 Mycobacteria form some of the most notorious and difficult-to-treat bacterial pathogens. As a group, they are intrinsically resistant to many commonly used antibiotics, such as tetracyclines and beta-lactams. In addition to intrinsic resistances, acquired multidrug resistance has also been observed and documented in Mycobacterium tuberculosis (MTB ...
Gan WC, Ng HF, Ngeow YF.
europepmc +4 more sources
Linezolid for multidrug-resistant tuberculosis. [PDF]
The Lancet Infectious Diseases, 2013 In their Comment in The Lancet Infectious Diseases, Kwok-Chiu Chang and colleagues concluded that expansion of access to linezolid for complicated cases of drug-resistant tuberculosis risks the loss of a potentially useful drug and could promote the emergence and spread of drug-resistant tuberculosis in the community.
Cox, H, Ford, N, Goemaere, E, Hughes, J
core +4 more sources
Linezolid resistance in patients with drug-resistant TB. [PDF]
Int J Tuberc Lung Dis, 2023 Vengurlekar D +10 more
europepmc +3 more sources
Parallel evolution of linezolid-resistant Staphylococcus aureus in patients with cystic fibrosis
Microbiology Spectrum, 2023 Linezolid is an antibiotic used to treat serious Staphylococcus aureus infections. Resistance to linezolid is considered rare but could emerge with repeated dosing.
Nicholas J. Pitcher +13 more
doaj +1 more source
Low Rate of Acquired Linezolid Resistance in Multidrug-Resistant Tuberculosis Treated With Bedaquiline-Linezolid Combination. [PDF]
Front Microbiol, 2021 In this retrospective study in China, we aimed to: (1) determine the prevalence of linezolid (LZD) resistance among multidrug-resistant tuberculosis (MDR-TB)-infected patients; (2) monitor for dynamic LZD susceptibility changes during anti-TB treatment; and (3) explore molecular mechanisms conferring LZD resistance.
Du J +13 more
europepmc +5 more sources
Characterization of In Vitro Resistance to Linezolid in Mycobacterium abscessus
Microbiology Spectrum, 2023 Single-step selection of Mycobacterium abscessus mutants resistant to linezolid yielded high-level resistance at a low frequency that was associated with mutations in 23S rRNA or the ribosomal protein L3.
Dereje A. Negatu +3 more
doaj +1 more source
Microorganisms, 2021 Whole genome sequencing is a useful tool to monitor the spread of resistance mechanisms in bacteria. In this retrospective study, we investigated genetic resistance mechanisms, sequence types (ST) and respective phenotypes of linezolid-resistant ...
Silke Huber +12 more
doaj +1 more source
Antimicrobial Resistance to Linezolid [PDF]
Clinical Infectious Diseases, 2004 Acquired resistance to linezolid, the first approved oxazolidinone, has been selected in laboratory experiments and has been observed in clinical isolates of gram-positive cocci. This resistance has typically been associated with single-nucleotide changes in varying numbers of copies of the genes encoding 23S ribosomal RNA.
Venkata G, Meka, Howard S, Gold
openaire +2 more sources