Results 11 to 20 of about 2,219,397 (166)

Linezolid Resistance in Staphylococci

Pharmaceuticals, 2010
Linezolid, the first oxazolidinone to be used clinically, is effective in the treatment of infections caused by various Gram-positive pathogens, including multidrug resistant enterococci and methicillin-resistant Staphylococus aureus.
Stefania Stefani, Dafne Bongiorno, Gino Mongelli, Floriana Campanile   +3 more
doaj   +4 more sources

Mechanisms of Linezolid Resistance in Mycobacteria [PDF]

Pharmaceuticals, 2023
Mycobacteria form some of the most notorious and difficult-to-treat bacterial pathogens. As a group, they are intrinsically resistant to many commonly used antibiotics, such as tetracyclines and beta-lactams.
Hien Fuh Ng, Yun Fong Ngeow
exaly   +3 more sources

Genomic and Phenotypic Analysis of Linezolid-Resistant Staphylococcus epidermidis in a Tertiary Hospital in Innsbruck, Austria

Microorganisms, 2021
Whole genome sequencing is a useful tool to monitor the spread of resistance mechanisms in bacteria. In this retrospective study, we investigated genetic resistance mechanisms, sequence types (ST) and respective phenotypes of linezolid-resistant ...
Silke Huber, Miriam A. Knoll, Michael Berktold, Reinhard Würzner, Anita Brindlmayer, Viktoria Weber, Andreas E. Posch, Katharina Mrazek, Sarah Lepuschitz, Michael Ante, Stephan Beisken, Dorothea Orth-Höller, Johannes Weinberger   +12 more
doaj   +2 more sources

Low prevalence of Cfr-mediated linezolid resistance among methicillin-resistant Staphylococcus aureus in a Spanish hospital: case report on linezolid resistance acquired during linezolid therapy. [PDF]

PLoS ONE, 2013
Linezolid is an effective antimicrobial agent to treat methicillin-resistant Staphylococcus aureus (MRSA). Resistance to linezolid due to the cfr gene is described worldwide. The present study aimed to analyze the prevalence of the cfr-mediated linezolid
Josep M Sierra, Mariana Camoez, Fe Tubau, Oriol Gasch, Miquel Pujol, Rogelio Martin, M Angeles Domínguez   +6 more
doaj   +3 more sources

Characterization of In Vitro Resistance to Linezolid in Mycobacterium abscessus

Microbiology Spectrum, 2023
Single-step selection of Mycobacterium abscessus mutants resistant to linezolid yielded high-level resistance at a low frequency that was associated with mutations in 23S rRNA or the ribosomal protein L3.
Dereje A. Negatu, Wassihun Wedajo Aragaw, Véronique Dartois, Thomas Dick   +3 more
doaj   +2 more sources

Mechanisms of Linezolid Resistance among Coagulase-Negative Staphylococci Determined by Whole-Genome Sequencing [PDF]

mBio, 2014
Linezolid resistance is uncommon among staphylococci, but approximately 2% of clinical isolates of coagulase-negative staphylococci (CoNS) may exhibit resistance to linezolid (MIC, ≥8 µg/ml). We performed whole-genome sequencing (WGS) to characterize the
Ryan Tewhey, Bing Gu, Theodoros Kelesidis, Carmen Charlton, April Bobenchik, Janet Hindler, Nicholas J. Schork, Romney M. Humphries   +7 more
doaj   +2 more sources

Transferable linezolid resistance genes (optrA and poxtA) in enterococci derived from livestock compost at Japanese farms [PDF]

Journal of Global Antimicrobial Resistance
Objectives: Linezolid is a last-resort antimicrobial in human clinical settings to treat multidrug-resistant Gram-positive bacterial infections. Mobile linezolid resistance genes (optrA, poxtA, and cfr) have been detected in various sources worldwide ...
Akira Fukuda, Chie Nakajima, Yasuhiko Suzuki, Masaru Usui   +3 more
doaj   +3 more sources

Subinhibitory Concentrations of Rifampicin Synergize with Linezolid to Delay Resistance Evolution in Clinical Methicillin-Resistant Staphylococcus Aureus

Microorganisms
Methicillin-resistant Staphylococcus aureus (MRSA) is a multidrug-resistant pathogen. Long-term clinical use of linezolid readily induces bacterial resistance in MRSA.
Chunhua Peng, Lu Lai, Chuanwei Zhang, Menglin Hu, Yalong Qi, Fangrui Liang, Ziyan Chen, Sailan Wang, Xiaohui Huang   +8 more
doaj   +2 more sources

Multiple mechanisms drive linezolid resistance in clinical Enterococcus faecium isolates by increasing poxtA gene expression

Journal of Global Antimicrobial Resistance
Objectives: The poxtA gene is a transferable linezolid-resistance gene that encodes an ATP-binding cassette F protein that prevents linezolid from inhibiting protein synthesis.
Fernando Lázaro-Perona, Paula Navarro-Carrera, Iván Bloise, Pablo Prieto-Casado, Isabel García-Pérez, Alberto Paradela, Fernando Corrales, Juana Cacho-Calvo, Jesús Mingorance   +8 more
doaj   +2 more sources

Genomic epidemiology reveals multiple mechanisms of linezolid resistance in clinical enterococci in China [PDF]

Annals of Clinical Microbiology and Antimicrobials
Background Infections caused by linezolid-resistant enterococci (LRE) are clinically difficult to treat and threaten patient health. However, there is a lack of studies on long time-span LRE strains in China.
Ziran Wang, Danping Liu, Jingjia Zhang, Lingli Liu, Zeming Zhang, Chang Liu, Songnian Hu, Linhuan Wu, Zilong He, Hongli Sun   +9 more
doaj   +2 more sources