Results 31 to 40 of about 686 (166)

Tn6349: a novel cfr- and poxtA-carrying transposon of enterococcal origin in a linezolid-resistant MRSA

, 2018
1. Introduction The spread of methicillin-resistant S. aureus (MRSA) is a worldwide public health concern, and percentages from invasive infections in our country have been constantly above 30% during the past decade. Linezolid is among the last resort agents for the treatment of MRSA infections, and resistance to this antibiotic, despite being ...
ANTONELLI A., D’ANDREA M. M., BRENCIANI A., MORRONI G., DI PILATO V., POLLINI S., FIORITI S., GIOVANETTI E., ROSSOLINI G. M.   +8 more
core   +3 more sources

Identification of plasmids co-carrying cfr(D)/optrA and cfr(D2)/poxtA linezolid resistance genes in two Enterococcus avium isolates from swine brain

Veterinary Microbiology, 2023
Oxazolidinones are critically important antibiotics to treat human infections caused by multidrug-resistant bacteria, therefore the occurrence of linezolid-resistant enterococci from food-producing animals poses a serious risk to human health. In this study, Enterococcus avium 38157 and 44917 strains, isolated from the brain of two unrelated piglets ...
Sonia Nina Coccitto, Marzia Cinthi, Serena Simoni, Carla Vignaroli, Francesca Romana Massacci, Elisa Albini, Cristiana Garofalo, Lucia Aquilanti, Chiara Francesca Magistrali, Andrea Brenciani, Eleonora Giovanetti   +10 more
openaire   +3 more sources

Frequent carriage of enterococci and other Lactobacillales with OptrA and PoxtA ribosomal protection resistance mechanisms among children from rural areas of Bolivia

International Journal of Infectious Diseases
Objectives: Oxazolidinones are antibiotics of remarkable clinical importance, and resistance to these drugs is a matter of concern. This study investigated the presence of optrA, poxtA and cfr transferable oxazolidinone resistance determinants among ...
Ilaria Baccani, Alberto Antonelli, Marco Coppi, Selene Rebecca Boncompagni, Tiziana di Maggio, Michele Spinicci, Marianne Strohmeyer, Herlan Gamboa, Veronica Poma, Ana Liz Villagrán, Simona Pollini, Lucia Pallecchi, Alessandro Bartoloni, Gian Maria Rossolini   +13 more
doaj   +4 more sources

Phylogeny of Transferable Oxazolidinone Resistance Genes and Homologs

Antibiotics
Oxazolidinone resistance, especially transmissible resistance, is a major public health concern, and the origin of this resistance mechanism is not yet resolved.
Gábor Kardos, Levente Laczkó, Eszter Kaszab, Bálint Timmer, Krisztina Szarka, Eszter Prépost, Krisztián Bányai   +6 more
doaj   +2 more sources

Genomic analysis of enterococci carrying optrA, poxtA, and vanA resistance genes from wild boars, Italy

Journal of Applied Microbiology
Abstract Aims To investigate enterococci carrying linezolid and vancomycin resistance genes from fecal samples recovered from wild boars Methods and results Florfenicol- and vancomycin-resistant enterococci, isolated on selective agar
Marzia Cinthi, Sonia Nina Coccitto, Francesca Romana Massacci, Elisa Albini, Giorgia Binucci, Marco Gobbi, Michele Tentellini, Nicoletta D'Avino, Alice Ranucci, Paola Papa, Chiara Francesca Magistrali, Andrea Brenciani, Eleonora Giovanetti   +12 more
openaire   +3 more sources

Emergence of Linezolid Resistance Genes <i>optrA</i> and <i>poxtA</i> in an Avian <i>Enterococcus asini</i>. [PDF]

Int J Mol Sci
Linezolid represents a critical last-resort treatment for severe multidrug-resistant (MDR) Gram-positive bacterial infections. Rising linezolid resistance in Enterococcus isolates threatens its efficacy; this study characterized the molecular features and transfer potential of plasmid-encoded linezolid resistance genes optrA and poxtA in a linezolid ...
Li Y, Tang H, Chen Y, Guo Y, Hong J, Luo X, Liu JH, Liu YY.   +7 more
europepmc   +2 more sources

Epidemiology and genetic diversity of linezolid-resistant Enterococcus clinical isolates in Belgium from 2013 to 2021

Journal of Global Antimicrobial Resistance
Objectives: Linezolid-resistant opportunistic human pathogens Enterococcus faecalis and Enterococcus faecium are emerging health threats as limited therapeutic options remain.
Olivier Mortelé, Stefanie van Kleef–van Koeveringe, Sarah Vandamme, Hilde Jansens, Herman Goossens, Veerle Matheeussen   +5 more
doaj   +2 more sources

Structural basis for PoxtA-mediated resistance to Phenicol and Oxazolidinone antibiotics [PDF]

, 2021
Abstract PoxtA and OptrA are ATP binding cassette (ABC) proteins of the F subtype (ABCF) that confer resistance to oxazolidinone, such as linezolid, and phenicol antibiotics, such as chloramphenicol. PoxtA/OptrA are often encoded on mobile genetic elements, facilitating their rapid spread amongst Gram-positive ...
Caillan Crowe-McAuliffe, Victoriia Murina, Marje Kasari, Hiraku Takada, Kathryn Jane Turnbull, Yury S. Polikanov, Arnfinn Sundsfjord, Kristin Hegstad, Gemma C. Atkinson, Daniel N. Wilson, Vasili Hauryliuk   +10 more
openaire   +1 more source

Detection of poxtA2 , a Presumptive poxtA Ancestor, in a Plasmid from a Linezolid-Resistant Enterococcus gallinarum Isolate [PDF]

Antimicrobial Agents and Chemotherapy, 2021
The poxtA gene encodes a protein belonging to the F lineage of the ATP-binding cassette superfamily, which can protect the bacterial ribosome from some anti-ribosomal antibiotics, including oxazolidinones (1).….
Baccani I., Antonelli A., Pilato V. D., Coppi M., Maggio T. D., Spinicci M., Villagran A. L., Revollo C., Bartoloni A., Rossolini G. M.   +9 more
openaire   +2 more sources

Characterization of an MDR Lactobacillus salivarius isolate harbouring the phenicol-oxazolidinone-tetracycline resistance gene poxtA

Journal of Antimicrobial Chemotherapy, 2022
Abstract Objectives To characterize the oxazolidinone resistance gene poxtA in a Lactobacillus salivarius isolate of pig origin. Methods L.
Yao Zhu, Wenlin Yang, Stefan Schwarz, Qiu Xu, Qin Yang, Lingli Wang, Siguo Liu, Wanjiang Zhang   +7 more
openaire   +4 more sources