Results 1 to 10 of about 367 (113)

Contezolid in the Treatment of Multidrug‐Resistant Tuberculous Meningitis: A Case Report [PDF]

Clinical Case Reports
Multidrug‐resistant tuberculous meningitis (MDR‐TBM) has a high mortality rate, and treatment options are limited. Linezolid is recommended for refractory cases but often causes intolerable adverse reactions such as peripheral neuropathy.
Na Wang, Xingyu Li, Qiaoyi Yan, Haitao Su, Yufeng Liu, Yanhong Li, Chunrong Yang, Yingchun Gu, Taoli Yan, Qiuzhen Wang, Xia Liu   +10 more
doaj   +3 more sources

In Vitro Antimicrobial Activity of Contezolid Against Mycobacterium tuberculosis and Absence of Cross-Resistance with Linezolid [PDF]

Microorganisms
Tuberculosis (TB) persists as a formidable global health threat, especially with the rising incidence of multidrug-resistant strains. This study aimed to evaluate the in vitro activity of contezolid, a novel oxazolidinone antibiotic, against ...
Li Wang, Jianxia Chen, Yifan He, Ruijuan Zheng, Jie Wang, Xiaochen Huang, Wei Sha, Lianhua Qin   +7 more
doaj   +3 more sources

Hematological Safety of Contezolid versus Linezolid in Stage 5 Chronic Kidney Disease: An Active-Comparator New-User Retrospective Cohort Study [PDF]

Drug Design, Development and Therapy
Wenjun Zhang,1,* Xinfeng Cai,2,* Ruigang Hou,1 Jinlin Guo,3 Ying Ma,4 Jianbang Kang,1 Xingang Li5 1Department of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Department of Pharmacy,
Zhang W, Cai X, Hou R, Guo J, Ma Y, Kang J, Li X   +6 more
doaj   +4 more sources

Towards precision dosing of contezolid: moderate hepatic impairment increases plasma concentration of contezolid in anti-tuberculosis treatment [PDF]

BMC Infectious Diseases
Background Contezolid is a novel oxazolidinone antibiotic with potent antimicrobial activity against Mycobacterium tuberculosis. To date, the plasma concentration profile of contezolid and its influencing factors remain poorly characterized. Methods This
Hong Lu, Manjiao Fu, Qunzhi Shi, Lin Liu, Ying Zeng, Pan Yan, Pengyu Li   +6 more
doaj   +2 more sources

Evaluation of contezolid’s cerebrospinal fluid concentration and safety in tuberculous meningitis patients [PDF]

Microbiology Spectrum
Tuberculous meningitis (TBM) is the most severe form of tuberculosis (TB) with high mortality. This study evaluated the cerebrospinal fluid (CSF) concentration and safety of the novel oxazolidinone contezolid compared to linezolid in TBM patients.
Mailing Huang, Yujin Wang, Tao Chen, Yu Lu, Naihui Chu, Wenjuan Nie   +5 more
doaj   +2 more sources

Evaluation of the clinical efficacy, safety, and permeability in pulmonary epithelial lining fluid of contezolid, a novel oxazolidinone drug, in adult patients with pneumonia [PDF]

Antimicrobial Agents and Chemotherapy
Contezolid is a novel oxazolidinone antibiotic for the treatment of gram-positive bacteria, which are one of the most common pathogens of pneumonia. We conducted a prospective, single-center, open-label study to evaluate the clinical and microbiological ...
Hailan Wu, Zixuan Cheng, Fengming Ding, Jianlan Hua, Hailin Wang, Xiannan Meng, Yanmei Cao, Yuancheng Chen, Yan Chen, Beining Guo, Tao Chen, Jing Zhang, Jing Zhang   +12 more
doaj   +2 more sources

Efficacy and Safety of Contezolid as Salvage Treatment for Gram-Positive Bacterial Infections: A Retrospective Multicenter Study [PDF]

Infection and Drug Resistance
Shujuan Ji,1 Zhihui Zhou,1 Yan Chen,1 Lu Sun,1 Binfeng Yu,1 Yunsong Yu2 1Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2Department of Infectious Diseases ...
Ji S, Zhou Z, Chen Y, Sun L, Yu B, Yu Y
doaj   +2 more sources

Concentration of contezolid in cerebrospinal fluid and serum in a patient with renal allograft tuberculosis and tuberculous meningoencephalitis [PDF]

BMC Infectious Diseases
Tuberculosis is a challenging and severe infection among solid organ transplant recipients. Contezolid, a new oxazolidinone antimicrobial, has exhibited potent activity against Mycobacterium tuberculosis with a safety profile superior to linezolid, which
Weijian Liu, Tian He, Hongjuan Qin, Peize Zhang   +3 more
doaj   +2 more sources

Activity of contezolid against methicillin-resistant Staphylococcus aureus in a rat model of foreign body osteomyelitis [PDF]

Microbiology Spectrum
Contezolid has activity against methicillin-resistant Staphylococcus aureus (MRSA), a common cause of orthopedic infection. In a rat model of foreign body osteomyelitis, 1.3 log10 cfu/g bone and 0.5 log10 cfu/k-wire reduction in MRSA was found in tibiae (
Sebastian C. Herren, Melissa J. Karau, Christina Koscianski, Kerryl E. Greenwood-Quaintance, Jayawant N. Mandrekar, Wen Wang, Robin Patel   +6 more
doaj   +2 more sources

Contezolid and polymyxin B nonapeptide combination reveals antibacterial synergy against multidrug-resistant Acinetobacter baumannii strains [PDF]

BMC Microbiology
Background Acinetobacter baumannii is a notorious clinical pathogen that predominantly causes nosocomial infections. The multidrug resistant Acinetobacter baumannii clinical isolates are becoming more prevalent on a global scale.
Danrui Hao, Yuhang Huang, Tianzhu Zhao, Runyu Wang, Wei Jiang, Xiangting Yuan, Xinrong Wang, Yiwen Chu, Kelei Zhao, Ting Huang, Zhenxing Wang   +10 more
doaj   +2 more sources