Results 1 to 10 of about 420 (147)

Contezolid for the Super-Elderly: Balancing Efficacy and Safety Through Pharmacokinetic Insights [PDF]

Clinical Interventions in Aging
Tingting Liu,1,* Beibei Liang,2,* Bing Liu,3,* Dengfeng Huang,2 Na Zhang,2 Xiangqun Fang,1 Hongxia Li,1 Yun Cai2 1Department of Pulmonary and Critical Care Medicine, The Second Medical Center and National Clinical Research Center ...
Liu T, Liang B, Liu B, Huang D, Zhang N, Fang X, Li H, Cai Y   +7 more
doaj   +6 more sources

The Therapeutic Effect of Contezolid in Complex Intra-Abdominal Infections [PDF]

Infection and Drug Resistance
Yongsheng Zhao,* Xianlei Xin,* Bin Wang, Lei He, Qinghua Zhao, Weizheng Ren Faculty of Hepato-Pancreato-Biliary Surgery, First Medical Center, Chinese PLA General Hospital, Beijing, People’s Republic of China*These authors contributed equally
Zhao Y, Xin X, Wang B, He L, Zhao Q, Ren W   +5 more
doaj   +7 more sources

Contezolid, a novel oxazolidinone antibiotic, may improve drug-related thrombocytopenia in clinical antibacterial treatment [PDF]

Frontiers in Pharmacology, 2023
One of the major limitations in the clinical use of existing oxazolidinone antibiotics is their characteristic adverse reactions, in particular thrombocytopenia.
Bi Li, Ying Liu, Jiaqi Luo, Yun Cai, Mengli Chen, Tianlin Wang   +5 more
doaj   +5 more sources

Antibacterial activity of the novel oxazolidinone contezolid (MRX-I) against Mycobacterium abscessus [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
ObjectiveTo evaluate contezolid (MRX-I) antibacterial activity against Mycobacterium abscessus in vitro and in vivo and to assess whether MRX-I treatment can prolong survival of infected zebrafish.MethodsMRX-I inhibitory activity against M.
Shan. Gao, Shan. Gao, Wenjuan. Nie, Wenjuan. Nie, Lina. Liu, Lei. Su, Yingxia. You, Ruixue. Geng, Naihui Chu, Naihui Chu   +9 more
doaj   +5 more sources

Successful Treatment of Severe Tuberculosis With Contezolid Add‐On Regimen in a Patient Complicated With Acute Thrombocytopenia: A Case Report [PDF]

Clinical Case Reports
Polypharmacy in managing severe tuberculosis patients usually poses a risk of adverse drug reactions. Contezolid is a new oxazolidinone antibiotic showing good in vitro and in vivo activity against Mycobacterium tuberculosis.
Liuqing Zhou, Yimin Wang, Jixue Zhou
doaj   +3 more sources

LC-MS/MS Method for Simultaneous Quantification of Three Oxazolidinone Antimicrobials in Human Plasma: Application to Therapeutic Drug Monitoring [PDF]

Drug Design, Development and Therapy
Na Zhang,* Nan Bai,* Ying Wang, Beibei Liang, Yun Cai Center of Medicine Clinical Research, Department of Pharmacy, Medical Supplies Center, PLA General Hospital, Beijing, 100853, People’s Republic of China*These authors ...
Zhang N, Bai N, Wang Y, Liang B, Cai Y
doaj   +5 more sources

Contezolid Harbored Equivalent Efficacy to Linezolid in Tuberculosis Treatment in a Prospective and Randomized Early Bactericidal Activity Study [PDF]

Infection and Drug Resistance
Guanglu Jiang,1,* Rongmei Liu,2,* Yi Xue,1 Qiping Ge,2 Lihui Nie,2 Zizheng Lv,2 Zhongshun Kong,2 Jin Shi,2 Hongmei Chen,2 Hua Li,2 Xiaoguang Wu,2 Li Xie,2 Yanhua Song,2 Hairong Huang,1 Mengqiu Gao2 1National Clinical Laboratory on Tuberculosis ...
Jiang G, Liu R, Xue Y, Ge Q, Nie L, Lv Z, Kong Z, Shi J, Chen H, Li H, Wu X, Xie L, Song Y, Huang H, Gao M   +14 more
doaj   +5 more sources

Evaluation of contezolid’s cerebrospinal fluid concentration and safety in tuberculous meningitis patients [PDF]

Microbiology Spectrum
Tuberculous meningitis (TBM) is the most severe form of tuberculosis (TB) with high mortality. This study evaluated the cerebrospinal fluid (CSF) concentration and safety of the novel oxazolidinone contezolid compared to linezolid in TBM patients.
Mailing Huang, Yujin Wang, Tao Chen, Yu Lu, Naihui Chu, Wenjuan Nie   +5 more
doaj   +2 more sources

Efficacy and Safety of Contezolid as Salvage Treatment for Gram-Positive Bacterial Infections: A Retrospective Multicenter Study [PDF]

Infection and Drug Resistance
Shujuan Ji,1 Zhihui Zhou,1 Yan Chen,1 Lu Sun,1 Binfeng Yu,1 Yunsong Yu2 1Department of Infectious Diseases, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China; 2Department of Infectious Diseases ...
Ji S, Zhou Z, Chen Y, Sun L, Yu B, Yu Y
doaj   +2 more sources

In Vitro Antimicrobial Activity of Contezolid Against Mycobacterium tuberculosis and Absence of Cross-Resistance with Linezolid [PDF]

Microorganisms
Tuberculosis (TB) persists as a formidable global health threat, especially with the rising incidence of multidrug-resistant strains. This study aimed to evaluate the in vitro activity of contezolid, a novel oxazolidinone antibiotic, against ...
Li Wang, Jianxia Chen, Yifan He, Ruijuan Zheng, Jie Wang, Xiaochen Huang, Wei Sha, Lianhua Qin   +7 more
doaj   +2 more sources