Results 41 to 50 of about 367 (113)

Regulatory utility of pharmacometrics in the development and evaluation of antimicrobial agents and its recent progress in China

CPT: Pharmacometrics &Systems Pharmacology, Volume 10, Issue 12, Page 1466-1478, December 2021., 2021
Abstract Pharmacometrics is an emerging science that interprets drug, disease, and trial information in a mathematical fashion to inform and facilitate efficient drug development and/or regulatory decisions. Pharmacometrics study is increasingly adopted in the regulatory review of new antimicrobial agents.
Ming Zhao, Yuancheng Chen, Dong Yang, Cheng Lyu, Xingchen Bian, Xin Li, Weiyi Qiu, Zhiwei Huang, Zijian Hu, Jing Zhang   +9 more
wiley   +1 more source

Contezolid for the Treatment of Drug-Resistant Tuberculosis in China: A Clinical Case Series

Infection and Drug Resistance
Yan-Jun Xiong,* Yu Xiao,* Lei Xie, Lei Gao, Yi Han, Peng-Fei Huang, Shuang Liu, Ya-Xue Liang, Hua Wang Department of Tuberculosis, Anhui Provincial Chest Hospital (Anhui Institute of Tuberculosis Control), Hefei, Anhui, 230022, People’s Republic ...
Xiong YJ, Xiao Y, Xie L, Gao L, Han Y, Huang PF, Liu S, Liang YX, Wang H   +8 more
exaly   +2 more sources

DataSheet1_Dose adjustment not required for contezolid in patients with moderate hepatic impairment based on pharmacokinetic/pharmacodynamic analysis.docx

, 2023
Objective: Contezolid is an oxazolidinone antimicrobial agent newly approved for treatment of Gram-positive bacterial infections. It is primarily metabolized by the liver. This study aimed to assess whether it is required to adjust the dose of contezolid
Jingjing Wang (140791), Yu Wang (12152), Huahui Yang (3749584), Hailin Wang (67695), Hong Yuan (104486), Hailan Wu (10203665), Junzhen Wu (5611964), Jing Zhang (23775), Xinyi Yang (324560), Jufang Wu (8744985)   +9 more
core   +1 more source

Novel oxazolidinones harbor potent in vitro activity against the clinical isolates of multidrug-resistant Mycobacterium tuberculosis in China

Frontiers in Medicine, 2022
ObjectiveTo investigate the in vitro activities of five oxazolidinones in parallel against the reference strains of different mycobacterial species and clinical isolates of Mycobacterium tuberculosis (Mtb), and shed light on the differences in the ...
Chenqian Wang, Chenqian Wang, Guirong Wang, Fengmin Huo, Yi Xue, Junnan Jia, Lingling Dong, Liping Zhao, Fen Wang, Hairong Huang, Hongfei Duan   +10 more
doaj   +1 more source

Table_1_Case report: Successful treatment with contezolid in a patient with tuberculous meningitis who was intolerant to linezolid.docx

, 2023
Tuberculous meningitis (TBM) is the most common form of central nervous system tuberculosis (TB) and the most severe form of extrapulmonary TB. It often presents with non-specific symptoms initially and has a high mortality and disability rate. With good
Tingting Guan (5027489), Chao Jiang (122046), Jing Zhang (23775), Guichuan Wan (17203966), Linchuan Lang (17203969), Zhe Xu (127066), Lianzhi Wang (17203972)   +6 more
core   +1 more source

Rare tuberculosis in recipients of allogeneic hematopoietic stem cell transplantation successfully treated with contezolid–a typical case report and literature review

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundTuberculosis (TB) is a rare but potentially devastating complication in hematopoietic stem cell transplantation (HSCT) recipients. Myelosuppression-related antibiotics should be used cautiously in patients with hematological malignancies ...
Junhong Li, Junhong Li, Zhaoxian Yu, Zhaoxian Yu, Yingyi Jiang, Yingyi Jiang, Suihua Lao, Suihua Lao, Dexian Li, Dexian Li   +9 more
doaj   +1 more source

Case report: Successful treatment with contezolid in a patient with tuberculous meningitis who was intolerant to linezolid

Frontiers in Medicine, 2023
Tuberculous meningitis (TBM) is the most common form of central nervous system tuberculosis (TB) and the most severe form of extrapulmonary TB. It often presents with non-specific symptoms initially and has a high mortality and disability rate. With good
Zhe Xu, Jing Zhang, Tingting Guan, Guichuan Wan, Chao Jiang, Linchuan Lang, Lianzhi Wang   +6 more
doaj   +1 more source

Discovery of Antibacterial Contezolid Acefosamil: Innovative O‑Acyl Phosphoramidate Prodrug for IV and Oral Therapies

, 2022
New oral antibiotic contezolid (CZD) is effective against Gram-positive infections but unsuitable for intravenous (IV) administration due to its modest solubility.
Chun Liu (47227), Shicong Liu (12975889), Changqing Wang (211895), Yunhua Xu (1794451), Xinghai Wang (2421052), Zhengyu Yuan (12975892), Mikhail F. Gordeev (2675770), Xueliang Zhang (801854), Qing Dai (552194), Hailin Wang (67695), Jinqian Liu (1825714), Wen Wang (6570), Li Zhang (8200)   +12 more
core   +1 more source

Data_Sheet_1_Antibacterial and anti-biofilm activity of radezolid against Staphylococcus aureus clinical isolates from China.PDF

, 2023
Although the potent antibacterial ability of radezolid against Staphylococcus aureus has been widely reported worldwide, its antibacterial and anti-biofilm activity against the S. aureus clinical isolates from China remains elusive.
Chai Bao (15356569), Ying Wei (214901), Xinyi Cao (3398783), Guiqiu Li (9373619), Zhijian Yu (778086), Yanpeng Xiong (9984512), Xiangbing Deng (534193), Qiwen Deng (530955), Zewen Wen (8887517), Cong Wang (107450)   +9 more
core   +1 more source

Penetration of Contezolid into bone tissues and body fluids in patients undergoing artificial hip or knee replacement surgery: A prospective cohort study

Journal of Global Antimicrobial Resistance
Purpose: This study aimed to examine the pharmacokinetic (PK) characteristics and penetration of contezolid into bone tissues and body fluids in patients undergoing artificial hip or knee replacement surgery.
Feng Yin, Hailan Wu, Yuancheng Chen, Yan Chen, Mengting Chen, Beining Guo, Hailin Wang, Yanmei Cao, Tao Chen, Jing Zhang   +9 more
doaj   +1 more source