Results 31 to 40 of about 420 (147)

Plasma and CSF pharmacokinetic characteristics of second-line anti-tuberculosis drugs in a patient with multidrug-resistant tuberculous meningitis [PDF]

BMC Infectious Diseases
Background The treatment of multidrug-resistant tuberculous meningitis (MDR-TBM) presents significant challenges, as the ability of different anti-tuberculosis (anti-TB) drugs to penetrate the blood-brain barrier varies greatly.
Jinlong Gao, Jie Cao, Jinmeng Li, Xiaohong Pan, Huijie Wang, Xinjun Cai, Yuanyuan Chen   +6 more
doaj   +2 more sources

Nephrotoxicity of New Antibiotics: A Systematic Review [PDF]

Toxics
Drug-induced nephrotoxicity is a common and serious problem in clinical practice. We conducted a systematic review of studies reporting nephrotoxicity events associated with antibiotics approved since 2018.
Panagiotis Stathopoulos, Laura T. Romanos, Charalampos Loutradis, Matthew E. Falagas   +3 more
doaj   +2 more sources

Effective sequential therapy of linezolid and contezolid against HA-MRSA-induced necrotizing pneumonia in a 95-year-old patient with multimorbidity [PDF]

BMC Infectious Diseases
Background Despite progress in new antibiotic development, active surveillance, and infection prevention, health care-associated methicillin-resistant Staphylococcus aureus (HA-MRSA) remains a major pathogen; it continues to pose a high-risk threat ...
Ran Wang, Shuping Shen, Tianping Zheng, Yuxing Zhang, Wei Xu, Jianqing Wu   +5 more
doaj   +2 more sources

The Structure, Properties, and Clinical Utility of Contezolid for Antituberculosis: A Narrative Review [PDF]

Infectious Diseases and Therapy
Tuberculosis (TB) continues to represent a significant global public health concern, with China being a country that bears the burden of a high incidence of TB cases on a global scale.
Tao Chen, Weili Li, Fangxue Shen, Wenjuan Nie, Fan Wu   +4 more
doaj   +2 more sources

Sequential Therapy of Linezolid and Contezolid to Treat Hematogenous Lung Abscess Caused by Staphylococcus aureus in a Congenital Cerebral Hypoplasia Patient: A Case Report [PDF]

Infection and Drug Resistance
Shuang Zhou,1 Chengqi Xin,2– 5 Wenjuan Liu1 1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China; 2Stem Cell Clinical Research Center, The First ...
Zhou S, Xin C, Liu W
doaj   +2 more sources

Contezolid-Containing Regimen Successfully Treated Multiple Drug Resistance Mycobacterium Abscessus Complex Infection of Skin: A Case Report and Literature Review [PDF]

Infection and Drug Resistance
Xusheng Gao, Caihong Ding, Dan Xie, Qing Wang, Peipei Jiang, Yuyu Wang, Yu Xiong Department of Tuberculosis, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, People’s Republic of ChinaCorrespondence: Yu Xiong, Department of ...
Gao X, Ding C, Xie D, Wang Q, Jiang P, Wang Y, Xiong Y   +6 more
doaj   +2 more sources

Sepsis and pneumonia caused by Enterococcus faecium following liver transplantation treated with contezolid as the first-line therapy

Journal of Global Antimicrobial Resistance
Background: Enterococcus faecium (E. faecium) stands as a prominent pathogen contributing to Gram-positive bacterial infections in individuals who have undergone liver transplantation.
Xiangyan Liu, Zhuoyi Wang, Weilin Wu, Shusen Zheng   +3 more
doaj   +3 more sources

Compassionate Use of Contezolid for the Treatment of Tuberculous Pleurisy in a Patient with a Leadless Pacemaker

Infection and Drug Resistance, 2022
Yixin Kang,1,* Cheng Ge,2,* Huan Zhang,3 Saizhe Liu,4 Hongyang Guo,4 Junchang Cui1 1Department of Respiratory Diseases, the First Medical Center, Chinese People’s Liberation Army General Hospital, Beijing, 100853, People’s Republic of China ...
Kang Y, Ge C, Zhang H, Liu S, Guo H, Cui J   +5 more
doaj   +3 more sources

In-vitro antimicrobial activity of new antimicrobial agents against Streptococcus pneumoniae and potential resistance mechanisms: a multicenter study [PDF]

BMC Microbiology
Background Streptococcus pneumoniae is a major cause of invasive and non-invasive diseases, particularly in children and immunocompromised individuals, with an annual mortality of approximately 800,000 children worldwide. The rise of antibiotic-resistant
Zichen Lei, Qi Liu, Yiqun Ma, Xinrui Yang, Hao Zu, Ziyao Li, Feilong Zhang, Dongya Pu, Yulin Zhang, Binghuai Lu   +9 more
doaj   +2 more sources

1118. Population Pharmacokinetics of Contezolid Acefosamil and Contezolid – Rationale for a Safe and Effective Loading Dose Regimen [PDF]

Open Forum Infectious Diseases, 2021
Abstract Background Contezolid (CZD) is a novel oral oxazolidnone with comparable activity and potentially improved safety compared to current oxazolidinones. The intravenous (IV) double prodrug contezolid acefosamil (CZDa) is converted via MRX-1352 to active CZD. CZDa paired with CZD holds promise as
Bulitta, Jürgen B, Hafkin, Barry, Fang, Edward   +2 more
openaire   +1 more source