Results 31 to 40 of about 367 (113)

Safety and Effectiveness of Contezolid versus Linezolid in Drug-Resistant Tuberculosis: A 12-Month Retrospective Study from China [PDF]

Infection and Drug Resistance
Yu Xiao,* Peng-Fei Huang,* Lei Xie, Lei Gao, Yi Han, Shuang Liu, Ya-Xue Liang, Yan-Jun Xiong, Hua Wang Department of Tuberculosis, Anhui Provincial Chest Hospital (Anhui Institute of Tuberculosis Control), Hefei, Anhui, 230022, People’s ...
Xiao Y, Huang PF, Xie L, Gao L, Han Y, Liu S, Liang YX, Xiong YJ, Wang H   +8 more
doaj   +2 more sources

Contezolid Harbored Equivalent Efficacy to Linezolid in Tuberculosis Treatment in a Prospective and Randomized Early Bactericidal Activity Study [PDF]

Infection and Drug Resistance
Guanglu Jiang,1,* Rongmei Liu,2,* Yi Xue,1 Qiping Ge,2 Lihui Nie,2 Zizheng Lv,2 Zhongshun Kong,2 Jin Shi,2 Hongmei Chen,2 Hua Li,2 Xiaoguang Wu,2 Li Xie,2 Yanhua Song,2 Hairong Huang,1 Mengqiu Gao2 1National Clinical Laboratory on Tuberculosis ...
Jiang G, Liu R, Xue Y, Ge Q, Nie L, Lv Z, Kong Z, Shi J, Chen H, Li H, Wu X, Xie L, Song Y, Huang H, Gao M   +14 more
doaj   +1 more source

Efficacy of Contezolid in the Treatment of Catheter-Related Bloodstream Infections Caused by Methicillin-Resistant Staphylococcus aureus in a Patient with Hepatorenal Syndrome and Acute Kidney Injury: A Case Report [PDF]

Infection and Drug Resistance
Xiucui Zhang,* Huili Huang,* Jianrong Wang, Bo Wei Department of Infectious Disease, Changzheng Hospital, Navy Medical University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bo Wei ...
Zhang X, Huang H, Wang J, Wei B
doaj   +1 more source

Sequential Therapy of Linezolid and Contezolid to Treat Hematogenous Lung Abscess Caused by Staphylococcus aureus in a Congenital Cerebral Hypoplasia Patient: A Case Report [PDF]

Infection and Drug Resistance
Shuang Zhou,1 Chengqi Xin,2– 5 Wenjuan Liu1 1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China; 2Stem Cell Clinical Research Center, The First ...
Zhou S, Xin C, Liu W
doaj   +1 more source

Contezolid-Containing Regimen Successfully Treated Multiple Drug Resistance Mycobacterium Abscessus Complex Infection of Skin: A Case Report and Literature Review [PDF]

Infection and Drug Resistance
Xusheng Gao, Caihong Ding, Dan Xie, Qing Wang, Peipei Jiang, Yuyu Wang, Yu Xiong Department of Tuberculosis, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, People’s Republic of ChinaCorrespondence: Yu Xiong, Department of ...
Gao X, Ding C, Xie D, Wang Q, Jiang P, Wang Y, Xiong Y   +6 more
doaj   +1 more source

In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China

Frontiers in Microbiology, 2021
Contezolid is a novel oxazolidinone, which exhibits potent activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and penicillin-resistant Streptococcus pneumoniae ...
Siheng Wang, Chang Cai, Yingbo Shen, Chengtao Sun, Qingxin Shi, Ningjun Wu, Shufang Zheng, Jiao Qian, Rong Zhang, Hongwei Zhou   +9 more
doaj   +1 more source

Dose adjustment not required for contezolid in patients with moderate hepatic impairment based on pharmacokinetic/pharmacodynamic analysis

Frontiers in Pharmacology, 2023
Objective: Contezolid is an oxazolidinone antimicrobial agent newly approved for treatment of Gram-positive bacterial infections. It is primarily metabolized by the liver. This study aimed to assess whether it is required to adjust the dose of contezolid
Junzhen Wu, Junzhen Wu, Xinyi Yang, Jufang Wu, Jufang Wu, Jingjing Wang, Hailan Wu, Hailan Wu, Hailan Wu, Yu Wang, Yu Wang, Yu Wang, Hong Yuan, Hong Yuan, Huahui Yang, Hailin Wang, Jing Zhang, Jing Zhang, Jing Zhang, Jing Zhang   +19 more
doaj   +1 more source

Strategies to Improve the Potency of Oxazolidinones towards Bacterial Biofilms

Chemistry – An Asian Journal, Volume 17, Issue 11, June 1, 2022., 2022
Biofilms play a key role in chronic infections yet they are highly resistant to antibiotic treatment. One approach to develop new anti‐biofilm agents is to modify the structure of existing antibiotics to target biofilms. In this review, we provide insight into strategies used to design more potent oxazolidinone compounds with activity against bacterial
Audrey R. N. Ndukwe, Sandra Wiedbrauk, Nathan R. B. Boase, Kathryn E. Fairfull‐Smith   +3 more
wiley   +1 more source

Advances in Therapeutic Drug Monitoring and Pharmacokinetic Researches of Oxazolidinone Antibacterial Agents in the Elderly Patients. [PDF]

Clin Interv Aging
BACKGROUND: Elderly patients are at increased risk of infection with methicillin-resistant Staphylococcus aureus (MRSA). Therefore, this article comprehensively reviews the progress in therapeutic drug monitoring (TDM) and pharmacokinetic (PK) studies of
Liu T, Li Z, Wei G, Yang Y, Wang F, Wang Y, Kang K, Yang P, Li H, Liu B, Fang X.   +10 more
europepmc   +2 more sources

Advances in Key Drug Target Identification and New Drug Development for Tuberculosis

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
Tuberculosis (TB) is a severe infectious disease worldwide. The increasing emergence of drug‐resistant Mycobacterium tuberculosis (Mtb) has markedly hampered TB control. Therefore, there is an urgent need to develop new anti‐TB drugs to treat drug‐resistant TB and shorten the standard therapy.
Jie Mi, Wenping Gong, Xueqiong Wu, Atef M. Al Attar   +3 more
wiley   +1 more source