Results 11 to 20 of about 420 (147)

Safety Evaluation of Contezolid (MRX-I) Versus Linezolid in Sprague-Dawley Rats [PDF]

Drugs in R&D
Background & Objectives Contezolid (MRX-I) is a novel ortho-fluorophenyl dihydropyridone developed by MicuRx Pharmaceuticals, Inc. It has been approved for the treatment of drug-resistant Gram-positive bacterial infections with relatively lower toxicity ...
Liping Wei, Min Hong, Min Lu, Yimin Qian, Qingmei Li, Naping Tang, Hua Li, Yan Chang, Yunliang Qiu   +8 more
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Activity of contezolid against methicillin-resistant Staphylococcus aureus in a rat model of foreign body osteomyelitis [PDF]

Microbiology Spectrum
Contezolid has activity against methicillin-resistant Staphylococcus aureus (MRSA), a common cause of orthopedic infection. In a rat model of foreign body osteomyelitis, 1.3 log10 cfu/g bone and 0.5 log10 cfu/k-wire reduction in MRSA was found in tibiae (
Sebastian C. Herren, Melissa J. Karau, Christina Koscianski, Kerryl E. Greenwood-Quaintance, Jayawant N. Mandrekar, Wen Wang, Robin Patel   +6 more
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Dose adjustment not required for contezolid in patients with moderate hepatic impairment based on pharmacokinetic/pharmacodynamic analysis

Frontiers in Pharmacology, 2023
Objective: Contezolid is an oxazolidinone antimicrobial agent newly approved for treatment of Gram-positive bacterial infections. It is primarily metabolized by the liver. This study aimed to assess whether it is required to adjust the dose of contezolid
Junzhen Wu, Junzhen Wu, Xinyi Yang, Jufang Wu, Jufang Wu, Jingjing Wang, Hailan Wu, Hailan Wu, Hailan Wu, Yu Wang, Yu Wang, Yu Wang, Hong Yuan, Hong Yuan, Huahui Yang, Hailin Wang, Jing Zhang, Jing Zhang, Jing Zhang, Jing Zhang   +19 more
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Plasma Concentrations of Contezolid and Its Efficacy and Safety in Elderly Patients with Multidrug-Resistant Tuberculosis and Renal Insufficiency [PDF]

Infection and Drug Resistance
Xiaoqing Ma,* Ruoying Zhang,* Xinjun Cai, Yuying Lang, Huaichong Wang, Jinmeng Li Department of Pharmacy, Hangzhou Red Cross Hospital, Hangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinmeng ...
Ma X, Zhang R, Cai X, Lang Y, Wang H, Li J   +5 more
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The antibiotic therapy containing contezolid successfully treated methicillin-sensitive Staphylococcus aureus infective endocarditis accompanied with cerebrovascular complications [PDF]

BMC Infectious Diseases
Background Staphylococcus aureus infective endocarditis (IE) in native valves is associated with high mortality rates and is prone to various complications, including embolic strokes, which often result in poor prognoses.
Yong Chen, Jianwei Ren, Fei Li, Xiaofang Ye, Yuanxing Wu   +4 more
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In vitro Activity of Contezolid Against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus, and Strains With Linezolid Resistance Genes From China

Frontiers in Microbiology, 2021
Contezolid is a novel oxazolidinone, which exhibits potent activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), and penicillin-resistant Streptococcus pneumoniae ...
Siheng Wang, Chang Cai, Yingbo Shen, Chengtao Sun, Qingxin Shi, Ningjun Wu, Shufang Zheng, Jiao Qian, Rong Zhang, Hongwei Zhou   +9 more
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Hematological Safety of Contezolid versus Linezolid in Stage 5 Chronic Kidney Disease: An Active-Comparator New-User Retrospective Cohort Study [PDF]

Drug Design, Development and Therapy
Wenjun Zhang,1,* Xinfeng Cai,2,* Ruigang Hou,1 Jinlin Guo,3 Ying Ma,4 Jianbang Kang,1 Xingang Li5 1Department of Pharmacy, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Department of Pharmacy,
Zhang W, Cai X, Hou R, Guo J, Ma Y, Kang J, Li X   +6 more
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Concentration of contezolid in cerebrospinal fluid and serum in a patient with renal allograft tuberculosis and tuberculous meningoencephalitis [PDF]

BMC Infectious Diseases
Tuberculosis is a challenging and severe infection among solid organ transplant recipients. Contezolid, a new oxazolidinone antimicrobial, has exhibited potent activity against Mycobacterium tuberculosis with a safety profile superior to linezolid, which
Weijian Liu, Tian He, Hongjuan Qin, Peize Zhang   +3 more
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Clinical Utility of Contezolid-Containing Regimens in 25 Cases of Linezolid-Intolerable Tuberculosis Patients

Infection and Drug Resistance, 2023
Jun Wang,1 Wenjuan Nie,1 Liping Ma,1 Qiang Li,1 Ruixue Geng,2 Wenhui Shi,1 Naihui Chu1 1Department of Tuberculosis, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, People’s Republic
Wang J, Nie W, Ma L, Li Q, Geng R, Shi W, Chu N   +6 more
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Treatment of Tuberculous Meningitis With Contezolid in a Patient With Complex Comorbidities: A Case Report and Literature Review [PDF]

Case Reports in Infectious Diseases
Central nervous system (CNS) tuberculosis (TB) is a severe manifestation of Mycobacterium tuberculosis (MTB) infection, characterized by high mortality. Contezolid, a novel oxazolidinone antibiotic, exhibits in vitro activity against MTB and may offer a ...
Qi Fan, Hong Sun, Shengsheng Liu
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