Results 11 to 20 of about 367 (113)

Treatment of Tuberculous Meningitis With Contezolid in a Patient With Complex Comorbidities: A Case Report and Literature Review [PDF]

Case Reports in Infectious Diseases
Central nervous system (CNS) tuberculosis (TB) is a severe manifestation of Mycobacterium tuberculosis (MTB) infection, characterized by high mortality. Contezolid, a novel oxazolidinone antibiotic, exhibits in vitro activity against MTB and may offer a ...
Qi Fan, Hong Sun, Shengsheng Liu
doaj   +3 more sources

Contezolid for the Super-Elderly: Balancing Efficacy and Safety Through Pharmacokinetic Insights [PDF]

Clinical Interventions in Aging
Tingting Liu,1,* Beibei Liang,2,* Bing Liu,3,* Dengfeng Huang,2 Na Zhang,2 Xiangqun Fang,1 Hongxia Li,1 Yun Cai2 1Department of Pulmonary and Critical Care Medicine, The Second Medical Center and National Clinical Research Center ...
Liu T, Liang B, Liu B, Huang D, Zhang N, Fang X, Li H, Cai Y   +7 more
doaj   +4 more sources

Successful Treatment of Severe Tuberculosis With Contezolid Add‐On Regimen in a Patient Complicated With Acute Thrombocytopenia: A Case Report [PDF]

Clinical Case Reports
Polypharmacy in managing severe tuberculosis patients usually poses a risk of adverse drug reactions. Contezolid is a new oxazolidinone antibiotic showing good in vitro and in vivo activity against Mycobacterium tuberculosis.
Liuqing Zhou, Yimin Wang, Jixue Zhou
doaj   +3 more sources

Contezolid in tuberculous meningitis: comparable efficacy and favorable safety [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundTuberculous meningitis (TBM) is the most severe and fatal form of tuberculosis (TB). Linezolid (Lzd), a key oxazolidinone with excellent central nervous system penetration, is widely used for TBM but is limited by significant adverse events ...
Yanmei Liao, Fei Lv, Tianwen Quan, Li Zheng, Guihui Wu   +4 more
doaj   +3 more sources

LC-MS/MS Method for Simultaneous Quantification of Three Oxazolidinone Antimicrobials in Human Plasma: Application to Therapeutic Drug Monitoring [PDF]

Drug Design, Development and Therapy
Na Zhang,* Nan Bai,* Ying Wang, Beibei Liang, Yun Cai Center of Medicine Clinical Research, Department of Pharmacy, Medical Supplies Center, PLA General Hospital, Beijing, 100853, People’s Republic of China*These authors ...
Zhang N, Bai N, Wang Y, Liang B, Cai Y
doaj   +4 more sources

From linezolid to contezolid: a strategy for safe continuation of therapy in complex tuberculosis [PDF]

Frontiers in Microbiology
BackgroundLinezolid (Lzd) is a cornerstone for drug-resistant and complex tuberculosis (TB), but its utility is severely limited by hematological and neurological toxicities.
Fei Lv, Rui Lin, Li Zheng, Mingming Zhang, Yanmei Liao, Guihui Wu   +5 more
doaj   +3 more sources

The antibiotic therapy containing contezolid successfully treated methicillin-sensitive Staphylococcus aureus infective endocarditis accompanied with cerebrovascular complications [PDF]

BMC Infectious Diseases
Background Staphylococcus aureus infective endocarditis (IE) in native valves is associated with high mortality rates and is prone to various complications, including embolic strokes, which often result in poor prognoses.
Yong Chen, Jianwei Ren, Fei Li, Xiaofang Ye, Yuanxing Wu   +4 more
doaj   +3 more sources

Plasma Concentrations of Contezolid and Its Efficacy and Safety in Elderly Patients with Multidrug-Resistant Tuberculosis and Renal Insufficiency [PDF]

Infection and Drug Resistance
Xiaoqing Ma,* Ruoying Zhang,* Xinjun Cai, Yuying Lang, Huaichong Wang, Jinmeng Li Department of Pharmacy, Hangzhou Red Cross Hospital, Hangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinmeng ...
Jinmeng Li
exaly   +3 more sources

Nephrotoxicity of New Antibiotics: A Systematic Review [PDF]

Toxics
Drug-induced nephrotoxicity is a common and serious problem in clinical practice. We conducted a systematic review of studies reporting nephrotoxicity events associated with antibiotics approved since 2018.
Panagiotis Stathopoulos, Laura T. Romanos, Charalampos Loutradis, Matthew E. Falagas   +3 more
doaj   +3 more sources

Successful Treatment of Intractable Tuberculous Peritonitis in a Woman with Chronic Kidney Allograft Dysfunction Using Contezolid Containing Regimen [PDF]

Infection and Drug Resistance
Weijian Liu,* Liangzi Yang,* Hongjuan Qin, Peize Zhang Department of Pulmonary Medicine and Tuberculosis, The Third People’s Hospital of Shenzhen, Shenzhen, Guangdong, People’s Republic of China*These authors contributed equally to this ...
Peize Zhang, Liangzi Yang
exaly   +3 more sources