Results 61 to 70 of about 420 (147)

Discovery of OJT008 as a Novel Inhibitor of Mycobacterium tuberculosis [PDF]

, 2022
Despite recent progress in the diagnosis of Tuberculosis (TB), the chemotherapeutic management of TB is still challenging. Mycobacterium tuberculosis (Mtb) is the etiological agent of TB, and TB is classified as the 13th leading cause of death globally ...
Onyenaka, Collins Chidi
core   +1 more source

Synthese, Charakterisierung und biologische Evaluation von MDR-modulierenden und antibakteriellen Wirkstoffen mit 1,4-Dihydropyridin- bzw. 9,10-Dihydroacridin-Grundstruktur [PDF]

, 2023
Ein wesentlicher Grund für das Versagen einer Krebs- bzw. Antibiotika-Therapie ist die MDR (multiple drug resistance). Wichtigster Resistenzmechanismus stellt die Überexpression von Effluxproteinen, insbesondere der ABC-Transporterfamilie, dar.
Kreutzer, David
core   +1 more source

Concentration of contezolid in cerebrospinal fluid and serum in a patient with tuberculous meningoencephalitis: A case report

International Journal of Antimicrobial Agents, 2023
Central nervous system (CNS) tuberculosis (TB) is a devastating and often life-threatening disease caused by Mycobacterium tuberculosis. Contezolid, a new oxazolidinone, has demonstrated potent antimycobacterial activity in both in-vivo and in-vitro studies, with lower toxicity than linezolid.
Wanru, Guo, Ming, Hu, Nana, Xu, Yanwan, Shangguan, Jiafeng, Xia, Wenjuan, Hu, Xiaomeng, Li, Qingwei, Zhao, Kaijin, Xu   +8 more
openaire   +2 more sources

Severe Community-Acquired Pneumonia Caused by Methicillin-Sensitive Staphylococcus aureus: Successfully Treated with Contezolid – A Case Report and Literature Review

Infection and Drug Resistance, 2023
Kaifei Wang, Ye Hu, Zhimei Duan, Han Fu, Xingshuo Hu, Ying Zhao, Ruoxuan Wen, Lina Li, Fei Xie College of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, People’s Republic of ChinaCorrespondence: Fei Xie, College of Pulmonary
Wang K, Hu Y, Duan Z, Fu H, Hu X, Zhao Y, Wen R, Li L, Xie F   +8 more
doaj  

Penetration of Contezolid into bone tissues and body fluids in patients undergoing artificial hip or knee replacement surgery: A prospective cohort study

Journal of Global Antimicrobial Resistance
Purpose: This study aimed to examine the pharmacokinetic (PK) characteristics and penetration of contezolid into bone tissues and body fluids in patients undergoing artificial hip or knee replacement surgery.
Feng Yin, Hailan Wu, Yuancheng Chen, Yan Chen, Mengting Chen, Beining Guo, Hailin Wang, Yanmei Cao, Tao Chen, Jing Zhang   +9 more
doaj   +1 more source

Optimising linezolid use for drug-resistant tuberculosis: pharmacokinetics, toxicity, and resistance [PDF]

, 2022
Background: Rifampicin-resistant tuberculosis (RR-TB) accounts for an expanding proportion of incident global TB cases and is a major barrier to global tuberculosis control. There is a need for more effective, safe, and well-tolerated drugs. Linezolid is
Wasserman, Sean Adam
core   +1 more source

2710. Long Term Use of Contezolid in Lung Transplant Recipients Infected with Nocardia Species

Open Forum Infectious Diseases, 2023
Abstract Background Nocardia commonly infects lung transplant recipients (LTR). Current oral options for long-term therapy may result in intolerance or adverse events. Contezolid is a new oxazolidinone antibiotic with potential less toxicity than linezolid that was approved in China.
openaire   +1 more source

Contezolid can replace linezolid in a novel combination with bedaquiline and pretomanid in a murine model of tuberculosis

Antimicrobial Agents and Chemotherapy, 2023
AbstractContezolid is a new oxazolidinone within vitroandin vivoactivity againstMycobacterium tuberculosiscomparable to that of linezolid. Pre-clinical and clinical safety studies suggest it may be less toxic than linezolid, making contezolid a potential candidate to replace linezolid in treatment of drug-resistant tuberculosis.
Deepak Almeida, Si-Yang Li, Jin Lee, Barry Hafkin, Khisimuzi Mdluli, Nader Fotouhi, Eric L. Nuermberger   +6 more
openaire   +2 more sources

Antibacterial and anti-biofilm activity of radezolid against Staphylococcus aureus clinical isolates from China

Frontiers in Microbiology, 2023
Although the potent antibacterial ability of radezolid against Staphylococcus aureus has been widely reported worldwide, its antibacterial and anti-biofilm activity against the S. aureus clinical isolates from China remains elusive.
Cong Wang, Cong Wang, Yanpeng Xiong, Chai Bao, Ying Wei, Ying Wei, Zewen Wen, Xinyi Cao, Xinyi Cao, Zhijian Yu, Xiangbing Deng, Guiqiu Li, Guiqiu Li, Qiwen Deng   +13 more
doaj   +1 more source

Unravelling the unusual: Enterococcus faecium in aspiration pneumonia complicated with lung abscess in a severely comorbid patient [PDF]

Aspiration pneumonia is a common respiratory infection that can lead to complications, including lung abscess. While typical causative agents include P. aeruginosa, K. pneumoniae, and S.
Asokan, Devi, Bawankar, Neha Sunil, Bhise, Swati M., Khadse, Ravindra R.   +3 more
core   +2 more sources