Results 11 to 20 of about 9,081 (170)
Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria
Molecules, 2020 The introductions of the bicyclic 4-nitroimidazole and the oxazolidinone classes of antimicrobial agents represented the most significant advancements in the infectious disease area during the past two decades.
Zhijun Zhuang +13 more
doaj +2 more sources
Molecular characterization of florfenicol and oxazolidinone resistance in Enterococcus isolates from animals in China [PDF]
Frontiers in Microbiology, 2022 Florfenicol is widely used for the treatment of bacterial infections in domestic animals. The aim of this study was to analyze the molecular mechanisms of florfenicol and oxazolidinone resistance in Enterococcus isolates from anal feces of domestic ...
Pingping Li +29 more
doaj +2 more sources
Easy Access to Evans’ Oxazolidinones. Stereoselective Synthesis and Antibacterial Activity of a New 2-Oxazolidinone Derivative [PDF]
Molecules, 2014 An interesting new approach was developed for the synthesis of Evans’ chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34 ...
Gaspar Diaz +3 more
doaj +2 more sources
Stereodivergent Synthesis of C5-α-Substituted Linezolid Derivatives From D-Mannitol and Structure-Antibacterial Activity Evaluation. [PDF]
ChiralityA stereodivergent route from D‐mannitol enables access to enantiopure C5‐α‐substituted linezolid analogues with full configurational control. Biological evaluation reveals that α‐substitution abolishes antibacterial activity irrespective of stereochemistry, establishing a strict steric limitation at C5 and highlighting the dominant role of substituent ...
Gálvez JA +3 more
europepmc +2 more sources
, 2016 (4S,5S)-4-Formyl-5-vinyl-2-oxazolidinone (4b), which is readily obtained via a zinc−silver-mediated reductive elimination of α-d-lyxofuranosyl phenyl sulfone (3b), is successfully converted to the naturally occurring, nonproteinogenic amino acid (2S,3R ...
Douglas D. McLeod (2297683) +1 more
core +3 more sources
Stereospecific synthesis of Pd(0)-catalyzed oxazolidinone with tetracyclic structure
, 2023 The efficient synthesis of a new class of oxazolidinone with strained rings is described. The allylic cis-diol as the key intermediate was first prepared via two steps starting from p-benzoquinone.
Latif Kelebekli (15350797) +1 more
core +2 more sources
Frontiers in Medicine, 2023 BackgroundContezolid is a novel oxazolidinone antibacterial agent, but there have been no reports of any pertinent clinical studies for the treatment of tuberculosis (TB).
Jun Wang, Liping Ma
doaj +1 more source
Antibiotics, 2023 Linezolid (LZD) and Tedizolid (TZD) are oxazolidinone antibiotic for meticillin-resistant Staphylococcus aureus (MRSA). Severe hyponatremia after LZD administration have been reported.
Yuichi Shibata +6 more
doaj +1 more source
Fixation into Oxazolidinone at Atmospheric Pressure
, 2023 Wide-range implementations are ongoing to utilize recombinant CO2 for value-added chemical synthesis via various catalytic approaches. Among others, thermal catalysis is a highly compelling and decisive approach to depleting CO2 in the atmosphere.
Sandeep Suryabhan Gholap +11 more
core +1 more source
A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban
Molecules, 2014 A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step.
Jianyong Yuan +5 more
doaj +1 more source