Results 11 to 20 of about 6,197 (174)

Contezolid in the Treatment of Multidrug-Resistant Tuberculous Meningitis: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Multidrug‐resistant tuberculous meningitis (MDR‐TBM) has a high mortality rate, and treatment options are limited. Linezolid is recommended for refractory cases but often causes intolerable adverse reactions such as peripheral neuropathy. Contezolid, a novel oxazolidinone, has shown better safety profiles in preclinical and early clinical ...
Wang N, Li X, Yan Q, Su H, Liu Y, Li Y, Yang C, Gu Y, Yan T, Wang Q, Liu X.   +10 more
europepmc   +2 more sources

Linezolid-associated Hyponatremia in Section Guillain-Barré Syndrome Patients in Intensive Care unit: A Retrospective Analysis [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Guillain-Barré Syndrome (GBS) is a neurological disorder associated with ascending paralysis due to damage to the peripheral nerves by the immune system.
Shweta Suresh Naik, Mathangi Krishnakumar, S Mouleeswaran, VJ Ramesh   +3 more
doaj   +1 more source

Tuberculosis patients with special clinical conditions treated with contezolid: three case reports and a literature review

Frontiers in Medicine, 2023
BackgroundContezolid is a novel oxazolidinone antibacterial agent, but there have been no reports of any pertinent clinical studies for the treatment of tuberculosis (TB).
Jun Wang, Liping Ma
doaj   +1 more source

A Retrospective Study to Compare the Incidence of Hyponatremia after Administration between Linezolid and Tedizolid

Antibiotics, 2023
Linezolid (LZD) and Tedizolid (TZD) are oxazolidinone antibiotic for meticillin-resistant Staphylococcus aureus (MRSA). Severe hyponatremia after LZD administration have been reported.
Yuichi Shibata, Mao Hagihara, Nobuhiro Asai, Arufumi Shiota, Jun Hirai, Nobuaki Mori, Hiroshige Mikamo   +6 more
doaj   +1 more source

Molecular characterization of florfenicol and oxazolidinone resistance in Enterococcus isolates from animals in China

Frontiers in Microbiology, 2022
Florfenicol is widely used for the treatment of bacterial infections in domestic animals. The aim of this study was to analyze the molecular mechanisms of florfenicol and oxazolidinone resistance in Enterococcus isolates from anal feces of domestic ...
Pingping Li, Pingping Li, Pingping Li, Pingping Li, Mengdi Gao, Mengdi Gao, Chunlin Feng, Chunlin Feng, Tielun Yan, Tielun Yan, Zhiqiong Sheng, Weina Shi, Weina Shi, Shuang Liu, Shuang Liu, Lei Zhang, Lei Zhang, Anqi Li, Anqi Li, Junwan Lu, Junwan Lu, Xi Lin, Xi Lin, Kewei Li, Kewei Li, Teng Xu, Qiyu Bao, Qiyu Bao, Caixia Sun, Caixia Sun   +29 more
doaj   +1 more source

A Novel Synthesis of the Oxazolidinone Antithrombotic Agent Rivaroxaban

Molecules, 2014
A facile synthetic route of rivaroxaban has been developed. Using commercially available (R)-epichlorohydrin and bromobenzene as the starting materials, rivaroxaban was obtained in 39% overall yield using a Goldberg coupling as the key step.
Jianyong Yuan, Kai Liu, Lun Li, Yong Yuan, Xuelei Liu, Yanwu Li   +5 more
doaj   +1 more source

Intracellular and in vivo activities of oxazolidinone drugs against Mycobacterium avium complex infection

Scientific Reports, 2023
The prevalence of Mycobacterium avium complex-pulmonary disease (MAC-PD) has become a growing concern worldwide, and current treatments involving macrolides (clarithromycin [CLR] or azithromycin), ethambutol, and rifampicin have limited success ...
Ju Mi Lee, Lee-Han Kim, Su-Young Kim, Byung Woo Jhun, Wonsik Lee, Sung Jae Shin   +5 more
doaj   +1 more source

Crystal structure of 4-methyl-N-{(E)-methyl[(3aR,8aS)-2-oxo-3,3a,8,8a-tetrahydro-2H-indeno[1,2-d][1,3]oxazol-3-yl]-λ4-sulfanylidene}benzenesulfonamide

Acta Crystallographica Section E: Crystallographic Communications, 2015
The formulation that the title compound, C18H18N2O4S2, adopts is a zwitterionic core with the charge separated to the sulfilimine S and N atoms and is supported by the two different S—N bond distances about the sulfinimine N atom [1.594 (2) and 1.631 (2) 
Patrícia A. Pereira, Bruce C. Noll, Allen G. Oliver, Gustavo P. Silveira   +3 more
doaj   +1 more source

Synergistic Activity of Nitroimidazole-Oxazolidinone Conjugates against Anaerobic Bacteria

Molecules, 2020
The introductions of the bicyclic 4-nitroimidazole and the oxazolidinone classes of antimicrobial agents represented the most significant advancements in the infectious disease area during the past two decades.
Zhijun Zhuang, Dawei Wan, Jun Ding, Shijie He, Qian Zhang, Xiaomei Wang, Ying Yuan, Yu Lu, Charles Z. Ding, Anthony Simon Lynch, Anna M. Upton, Christopher B. Cooper, William A. Denny, Zhenkun Ma   +13 more
doaj   +1 more source

Chiral Separation of Oxazolidinone Analogs by Capillary Electrophoresis Using Anionic Cyclodextrins as Chiral Selectors: Emphasis on Enantiomer Migration Order

Molecules, 2023
Comparative chiral separations of enantiomeric pairs of four oxazolidinone and two related thio-derivatives were performed by capillary electrophoresis, using cyclodextrins (CDs) as chiral selectors.
Zoltán-István Szabó, Francisc Boda, Béla Fiser, Máté Dobó, Levente Szőcs, Gergő Tóth   +5 more
doaj   +1 more source