Results 21 to 30 of about 4,750 (178)
Frontiers in Public Health, 2020 Oxazolidinones are one of the most important antimicrobials potentially active against glycopeptide- and β-lactam-resistant Gram-positive pathogens.
Lara M. Almeida +11 more
doaj +1 more source
Infection and Drug Resistance, 2021 Xia Yu,* Fengmin Huo,* Fen Wang,* Shu’an Wen, Guanglu Jiang, Yi Xue, Lingling Dong, Liping Zhao, Rui Zhu, Hairong Huang National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing ...
Yu X +9 more
doaj
Pharmaceutics, 2011 Like any other drug, antimicrobial drugs are prone to pharmacokinetic drug interactions. These drug interactions are a major concern in clinical practice as they may have an effect on efficacy and toxicity.
Jan-Willem C. Alffenaar +4 more
doaj +1 more source
Journal of Global Antimicrobial Resistance, 2022 Objectives: The aim of this study is to compare the in vitro activity and minimal inhibitory concentration (MIC) distributions of tedizolid and linezolid against Mycobacterium avium complex (MAC) strains using a reference broth microdilution assay and a ...
Eduardo Marfil +3 more
doaj +1 more source
Investigational and Experimental Drugs for Community-Acquired Pneumonia: the Current Evidence
Journal of Experimental Pharmacology, 2020 Juilia Sellarès-Nadal, Joaquin Burgos, Vicenç Falcó, Benito Almirante Infectious Diseases Department, Hospital Universitari Vall d’Hebron, Autonomous University of Barcelona, Barcelona, SpainCorrespondence: Benito ...
Sellarès-Nadal J +3 more
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Cu(I)/Ionic Liquids Promote the Conversion of Carbon Dioxide into Oxazolidinones at Room Temperature
Molecules, 2019 Recently, the efficient chemical fixation of carbon dioxide (CO2) into high value chemicals without using noble metal catalysts has become extremely appealing from the viewpoint of sustainable chemistry.
Jikuan Qiu +6 more
doaj +1 more source
Response to Emerging Infection Leading to Outbreak of Linezolid-Resistant Enterococci
Emerging Infectious Diseases, 2007 Linezolid was approved in 2000 for treatment of gram-positive coccal infections. We performed a case-control study during a hospital outbreak of linezolid-resistant enterococci (LRE) infections, comparing cases of LRE infection (cases) with linezolid ...
Marion A. Kainer +9 more
doaj +1 more source
International Journal of Infectious Diseases, 2021 Background: The natural resistance of rapidly growing mycobacteria (RGM) to multiple antibiotics renders the treatment of the infections caused less successful.
Shu’an Wen +9 more
doaj +1 more source
Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie International Edition, EarlyView.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +1 more source
Truncation of Samroiyotmycin: Tailored seco‐Acids as Novel Antimalaria Compounds
European Journal of Organic Chemistry, EarlyView.Six truncated samroiyotmycin‐derived antimalarials were synthesized by replacing the tosyloxazole unit with electron‐deficient aryl groups. The most active seco‐acid with EWG = 2 × CF3 outperformed the natural product SamA. Its enhanced activity supports a donor–acceptor interaction involving the electron‐poor aryl unit, consistent with inhibition of ...
Anton Czuczkowski +10 more
wiley +1 more source