Results 41 to 50 of about 4,750 (178)

Antimicrobial activity of linezolid against Gram-positive cocci isolated in Brazil

Brazilian Journal of Infectious Diseases
The new oxazolidinone linezolid and other antimicrobial agents used to treat Gram-positive infections were tested against 1,585 Gram-positive cocci; 1,260 staphylococci and enterococci isolates from patients hospitalized in Brazilian hospitals, and 325 S.
Helio S. Sader, Ana C. Gales, Ronald N. Jones   +2 more
doaj   +1 more source

Total Synthesis of Sacrolide A and Cytotoxic Evaluation

European Journal of Organic Chemistry, Volume 29, Issue 27, 17 July 2026.
Isolated from the edible cyanobacterium Aphanothece sacrum, sacrolide A is a highly potent antimicrobial and cytotoxic metabolite. Its total synthesis via a convergent strategy enabled accurate assessment of its effects on liver and colon cells, offering new insights into its bioactivity and potential health risks.
Priyanka Kataria, Kamel Hadj‐Kaddour, Alexis Giraudon, Jawad Belkheir, Alexandre Guy, Thierry Durand, Magali Gary‐Bobo, Camille Oger   +7 more
wiley   +1 more source

Iodine‐Triggered Cyclization of Epoxy Carbamates: A Practical Route to Oxazolidinones

Asian Journal of Organic Chemistry, Volume 15, Issue 7, July 2026.
Iodine‐triggered cyclization of epoxy benzyl carbamates to oxazolidinones under mild conditions. The transformation proceeds via SN2‐type epoxide opening followed by 5‐exo‐tet cyclization, delivering C5‐hydroxymethyl‐substituted oxazolidinones with high regioselectivity and no detectable regioisomers.
Yueh‐Ling Huang, Yi‐Lin Wang, Hui‐Yin Hsu, Cheng‐Kun Lin   +3 more
wiley   +1 more source

Linezolid‐induced lactic acidosis in critically ill patients: A multicentre study of incidence, severity and predictors

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2239-2249, July 2026.
Abstract Introduction Linezolid, a synthetic oxazolidinone for resistant gram‐positive infections, is generally associated with mild adverse effects such as gastrointestinal disturbances, but more serious reactions like lactic acidosis (LA) have also been reported.
Lina Naseralallah, Bodoor Aboujabal, Zahra Noureddine, Khaled Aboujabal, Somaya Koraysh   +4 more
wiley   +1 more source

Silica sulfuric acid: a versatile and reusable heterogeneous catalyst for the synthesis of N-acyl carbamates and oxazolidinones under solvent-free conditions

Bulletin of the Chemical Society of Ethiopia, 2011
Silica sulfuric acid catalyzes efficiently the reaction of carbamates and oxazolidinones with anhydrides under solvent-free conditions. All the reactions were done at room temperature and the N-acyl carbamates and oxazolidinones were obtained with high ...
Liqiang Wu, Xiaojuan Yang, Fulin Yan
doaj  

Management of Traumatic Penile Degloving Injury in a Resource‐Constrained Setting: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 7, July 2026.
ABSTRACT Genital degloving injuries from motorcycle accidents are uncommon, with most reported cases involving complete devascularisation requiring skin grafting. We present a 70‐year‐old male who presented to a rural health center following a high‐speed motorcycle accident with a unique distal pedicure circumferential penile skin avulsion.
Shehdev Meghwar, Umaya Memon, Vishan Das, Shankar Meghwar, Dhivya Bharathi, Siddhant Kumar Yadav   +5 more
wiley   +1 more source

A Critical Review of Oxazolidinones: An Alternative or Replacement for Glycopeptides and Streptogramins?

Canadian Journal of Infectious Diseases, 2001
OBJECTIVE: To review the available data on the oxazolidinones linezolid and eperezolid.
George G Zhanel, Coleen Schroeder, Lavern Vercaigne, Alfred S Gin, John Embil, Daryl J Hoban   +5 more
doaj   +1 more source

(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one

Molbank, 2018
(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one has been synthesized for the first time by the enantiospecific oxidative carbonylation of commercially available (S)-2-amino-3-methyl-1,1-diphenylbutan-1-ol.
Raffaella Mancuso, Rossana Miliè, Ida Ziccarelli, Mariangela Novello, Nicola Della Ca’, Bartolo Gabriele   +5 more
doaj   +1 more source

Chiral (Stereoselective) Drugs, Asymmetric Synthesis, and Racemic Resolution Methods

Chirality, Volume 38, Issue 7, July 2026.
Chirality is crucial in drug development since both biological targets in the organism and the majority of pharmaceutical compounds are chiral. The synthesis and resolution of chiral compounds are critical steps while developing chiral drugs. Asymmetric synthesis and racemic resolution are the two most common methods for obtaining enantiopure drugs ...
Burcu Karayavuz, Cigdem Karaaslan Kirmizioglu   +1 more
wiley   +1 more source

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source