Results 41 to 50 of about 2,355 (106)

Versatile Synthons for Optically Pure α-Amino Aldehydes and α-Amino Acids: (+)- and (−)-4,5-Dialkoxy-2-oxazolidinones

, 2016
Both enantiomers of trans-5-benzyloxy-4-methoxy- (BMOx) and trans-4,5-dimethoxy-2-oxazolidinones (DMOx), which are readily accessible from simple 2-oxazolone heterocycles, represent good candidates for a new class of chiral synthons for use in the ...
Takehisa Kunieda (2996403), Yusuke Nagasawa (3063765), Hirofumi Matsunaga (1520020), Toru Morita (3063768), Syunsuke Yahiro (3063762)   +4 more
core   +1 more source

Response to Emerging Infection Leading to Outbreak of Linezolid-Resistant Enterococci

Emerging Infectious Diseases, 2007
Linezolid was approved in 2000 for treatment of gram-positive coccal infections. We performed a case-control study during a hospital outbreak of linezolid-resistant enterococci (LRE) infections, comparing cases of LRE infection (cases) with linezolid ...
Marion A. Kainer, Rose A. Devasia, Timothy F. Jones, Bryan P. Simmons, Kelley Melton, Susan Chow, Joyce Broyles, Kelly L. Moore, Allen S. Craig, William Schaffner   +9 more
doaj   +1 more source

Comparison of the in vitro activity of linezolid, tedizolid, sutezolid, and delpazolid against rapidly growing mycobacteria isolated in Beijing, China

International Journal of Infectious Diseases, 2021
Background: The natural resistance of rapidly growing mycobacteria (RGM) to multiple antibiotics renders the treatment of the infections caused less successful.
Shu’an Wen, Xiaopan Gao, Weijie Zhao, Fengmin Huo, Guanglu Jiang, Lingling Dong, Liping Zhao, Fen Wang, Xia Yu, Hairong Huang   +9 more
doaj   +1 more source

A novel way to chiral 2-oxazolidinones: selenium-catalyzed cyclocarbonylation of 2-aminoethanols

, 2007
Selenium-catalyzed cyclocarbonylation of 2-aminoethanols with CO under atmospheric pressure at 30 degrees C afforded 2-oxazolidinones in excellent yields without any other co-catalyst.
Wang, Shudong, Yuan, Xiaohua, Lu, Shiwei, Li, Peng, 陆世维   +4 more
core   +1 more source

Oxazolidinones: mechanisms of resistance and mobile genetic elements involved [PDF]

, 2022
The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the treatment of severe infections in humans caused by MDR Gram-positive bacteria.
Schwarz, Stefan, Brenciani, Andrea, Morroni, Gianluca, Giovanetti, Eleonora   +3 more
core   +1 more source

Anaerobic bacteria: a neglected reservoir of mobile oxazolidinone resistance genes

Gut Microbes
Oxazolidinones are critical last-resort antimicrobials against severe infections caused by Gram-positive bacteria, whereas mobile oxazolidinone resistance genes (MORGs, including cfr, optrA, poxtA) severely compromise their clinical efficacy.
Simeng Liu, Shuangyu Xie, Yongshan Song, Ruichao Li, Andrea Brenciani, Stefan Schwarz, Wanjiang Zhang, Yao Zhu   +7 more
doaj   +1 more source

In vitro Antimicrobial Activity Comparison of Linezolid, Tedizolid, Sutezolid and Delpazolid Against Slowly Growing Mycobacteria Isolated in Beijing, China

Infection and Drug Resistance, 2021
Xia Yu,* Fengmin Huo,* Fen Wang,* Shu’an Wen, Guanglu Jiang, Yi Xue, Lingling Dong, Liping Zhao, Rui Zhu, Hairong Huang National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing ...
Yu X, Huo F, Wang F, Wen S, Jiang G, Xue Y, Dong L, Zhao L, Zhu R, Huang H   +9 more
doaj  

Emerging Treatment Options for Infections by Multidrug-Resistant Gram-Positive Microorganisms

Microorganisms, 2020
Antimicrobial agents are currently the mainstay of treatment for bacterial infections worldwide. However, due to the increased use of antimicrobials in both human and animal medicine, pathogens have now evolved to possess high levels of multi-drug ...
Despoina Koulenti, Elena Xu, Andrew Song, Isaac Yin Sum Mok, Drosos E. Karageorgopoulos, Apostolos Armaganidis, Sotirios Tsiodras, Jeffrey Lipman   +7 more
doaj   +1 more source

Novel oxazolidinones harbor potent in vitro activity against the clinical isolates of multidrug-resistant Mycobacterium tuberculosis in China

Frontiers in Medicine, 2022
ObjectiveTo investigate the in vitro activities of five oxazolidinones in parallel against the reference strains of different mycobacterial species and clinical isolates of Mycobacterium tuberculosis (Mtb), and shed light on the differences in the ...
Chenqian Wang, Chenqian Wang, Guirong Wang, Fengmin Huo, Yi Xue, Junnan Jia, Lingling Dong, Liping Zhao, Fen Wang, Hairong Huang, Hongfei Duan   +10 more
doaj   +1 more source

Clinical pharmacokinetics and pharmacodynamics of oxazolidinones

, 2017
Oxazolidinones are a class of synthetic antimicrobial agents with potent activity against a wide range of multidrug-resistant Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci ...
Muller, Laurent, Laurent Muller, Claire Roger, Roberts, Jason, Roger, Claire, Jason A. Roberts, Roberts, Jason A.   +6 more
core   +1 more source