Results 71 to 80 of about 2,355 (106)

Kinetic Resolution of 2-Oxazolidinones via Catalytic, Enantioselective N-Acylation

, 2016
Kinetic resolution of racemic 2-oxazolidinones via catalytic, enantioselective N-acylation has been achieved for the first time and with outstanding ...
Lei Guo (36221), Eric W. Uffman (2031355), Hui Jiang (102809), Vladimir B. Birman (1951207), Ximin Li (599024)   +4 more
core   +1 more source

3,5-Disubstituted Oxazolidinones as Ligands to Bind to the T-Box Riboswitch

, 2023
The synthesis of novel 3,5-Disubstituted oxazolidinones will be done to test for RNA binding ...
Williams, Kurtis
core   +2 more sources

Flipping the Card With Enantiodivergent Organocatalysis

Chemistry – A European Journal, Volume 32, Issue 29, 7 August 2026.
This minireview elaborates on recent organocatalytic strategies for achieving enantiodivergence—the ability to access both product enantiomers using a single chiral catalyst. It highlights how achiral stimuli, such as solvent polarity and chemical additives, along with minimal catalyst modifications, trigger stereochemical inversions in reactions ...
Debora Iapadre, Alessio Carioscia, Alessandro Brusa, Armando Carlone   +3 more
wiley   +1 more source

Oxazolidinones as novel human CCR8 antagonists

, 2007
High-throughput screening of the corporate compound collection led to the discovery of a novel series of N-substituted-5-aryl-oxazolidinones as potent human CCR8 antagonists. The synthesis, structure-activity relationships, and optimization of the series
Nguyen, Cuc, Feng Wang, Victoria M. Vinader, Cuc Nguyen, Victoria J. Barrett, Helen E. Connor, Guido Hartmann, J. Foley, James, Andy J. Harker, K. Kerns, Jeffery, M. Sarau, Henry, Rao, Parvathi, P. Andrew, David, L. Moore, Michael, Dwight M. Morrow, J. Jurewicz, Anthony, Browning, Chris, David P. Andrew, James J. Foley, J. Barrett, Victoria, A. Fornwald, James, Ashley P. Hancock, Kristen E. Belmonte, E. Connor, Helen, Jin, Jian, Hartmann, Guido, M. Morrow, Dwight, I. Stevenson, Graeme, Anthony J. Jurewicz, P. Hancock, Ashley, A. Rivero, Ralph, Chris Browning, Jeffery K. Kerns, Michael L. Moore, Wang, Feng, Jian Jin, Matthew J. Lindon, Wang, Yonghui, Parvathi Rao, Henry M. Sarau, J. Harker, Andy, Yonghui Wang, Ralph A. Rivero, E. Belmonte, Kristen, James A. Fornwald, J. Lindon, Matthew, M. Vinader, Victoria, Graeme I. Stevenson   +47 more
core   +1 more source

Design, Synthesis, X‐Ray Crystallographic Characterization, Anticholinesterase and Antioxidant Evaluation, and Molecular Modeling of Novel Dispiroindene‐Pyrrolidine Derivatives as Multifunctional Anti‐Alzheimer Agents

Drug Development Research, Volume 87, Issue 5, August 2026.
ABSTRACT A novel series of 5‐chloro‐N‐alkyl‐1′,1″‐dimethyl‐4′‐aryldispiro[indene‐2,3′‐pyrrolidine‐2′,3″‐indoline]−1,2″(3H)‐diones (4a–r) was rationally designed and synthesized via a one‐pot multicomponent reaction of N‐alkylated 5‐chloroisatin derivatives, 2‐(arylmethylidene)−2,3‐dihydro‐1H‐inden‐1‐ones (2a–i), and sarcosine (3).
Aisha A. Alsfouk, Riham A. El‐Shiekh, Benson M. Kariuki, Eman Sabry, Mohamed G. Abouelenein, Asmaa Saleh, Mahmoud G. A. Saleh, Aladdin M. Srour   +7 more
wiley   +1 more source

Applications of oxazolidinones as chiral auxiliaries in the asymmetric alkylation reaction applied to total synthesis

, 2022
Various chiral oxazolidinones (Evans’ oxazolidinones) have been employed as effective chiral auxiliaries in the asymmetric alkylation of different enolates.
Vahideh Zadsirjan (6272597), Behnaz Farajpour (9673459), Majid Mommahed Heravi (9225485)   +2 more
core   +1 more source

Dominant Role of Habitat Transformation in Driving the Divergence of Health‐Risk Related Microbial Functional Genes in Karst Mountain Parks: A Metagenomic Study

Ecology and Evolution, Volume 16, Issue 8, August 2026.
This manuscript elucidates the impact of transforming karst mountain forests into urban parks on health‐risk related microbial functional genes and its implications for mitigating potential public health exposures. Distinctively, the study advances prior research by evaluating the variation in health‐related functional genes within parks of varying ...
Weize Wang, Chunhua Cen, Jingyi Yang
wiley   +1 more source

Copper-catalyzed domino cyclization of propargylic alcohol with tosyl isocyanate to oxazolidinones

, 2016
A copper-catalyzed domino cyclization of propargylic alcohols with tosyl isocyanate for the synthesis of oxazolidinones has been developed. Various propargylic alcohols with an aryl or alkyl substituents worked smoothly to afford the corresponding ...
Xiu-Shuai Chen (3341609), Yan-Jun Liu (197444), Rui-Feng Yang (568223), Hu, Xiang-Ping, Liu, Yan-Jun, Hou, Chuan-Jin, Xiang-Ping Hu (1537561), Chen, Xiu-Shuai, Yang, Rui-Feng, Chuan-Jin Hou (2067520)   +9 more
core   +1 more source

Validated LC-MS/MS Assays for Novel Triazolyl-Oxazolidinones with Anticonvulsant Activities and Their Potential Applications in Stability and Pharmacokinetic Studies

Pharmaceuticals
Background: We recently synthesized a novel series of triazolyl-oxazolidinones (PH066, PH139, PH162, and PH166) that exhibited significant in vivo anticonvulsant activity in rat models of electrically- and chemically-induced seizures.
Mohsen A. Hedaya, Oludotun A. Phillips, Vidhya Thomas, Mohammad G. Qaddoumi, Samuel B. Kombian, Naser F. Al-Tannak   +5 more
doaj   +1 more source

Formation of Enantiopure 5-Substituted Oxazolidinones through Enzyme-Catalysed Kinetic Resolution of Epoxides

, 2016
Halohydrin dehalogenase from Agrobacterium radiobacter catalyzed the enantioselective ring opening of terminal epoxides with cyanate as a nucleophile, yielding 5-substituted oxazolidinones in high yields and with high enantiopurity (69−98% ee).
Dick B. Janssen (1566727), Maja Majerić Elenkov (1768090), Lixia Tang (2434207), Bernhard Hauer (1479469), Auke Meetsma (1997038)   +4 more
core   +1 more source