Results 91 to 100 of about 17,792 (252)
ChemBioChem, Volume 27, Issue 5, 13 March 2026.The synthesis of aromatic amino alcohols via a combination of an unspecific peroxygenase‐catalysed reaction, oxyfunctionalization, and addition of selected nucleophiles and electrophiles in a highly atom‐efficient manner was investigated. This study presents the design to aim for an atom‐efficient chemo‐enzymatic synthesis route towards aromatic amino ...
Simon Last +3 more
wiley +1 more source
, 2016 Various chiral oxazolidinones (Evans’ oxazolidinones) have been employed as effective chiral auxiliaries in the asymmetric alkylation of different enolates.
M. Heravi +2 more
semanticscholar +1 more source
Linezolid and Rifampicin Combination to Combat cfr-Positive Multidrug-Resistant MRSA in Murine Models of Bacteremia and Skin and Skin Structure Infection. [PDF]
, 2019 Linezolid resistance mediated by the cfr gene in MRSA represents a global concern. We investigated relevant phenotype differences between cfr-positive and -negative MRSA that contribute to pathogenesis, and the efficacy of linezolid-based combination ...
Li, Liang +6 more
core
Concise Synthesis of (+)-allo-Kainic Acid via MgI2-Mediated Tandem Aziridine Ring Opening-Formal [3+2] Cycloaddition [PDF]
, 2013 3-Methyl vinyl aziridine undergoes a mild MgI2-promoted S(N)2' ring opening and concomitant cyclization with fumarate Michael acceptors to give trisubstituted pyrrolidines. The process is efficient and highly diastereoselective. This methodology has been
Aggarwal, Varinder K. +3 more
core +1 more source
Safety of long-term use of linezolid: results of an open-label study
Therapeutics and Clinical Risk Management, 2016 Jose A Vazquez,1 Anthony C Arnold,2 Robert N Swanson,3 Pinaki Biswas,3 Matteo Bassetti4 1Section of Infectious Diseases, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA; 2UCLA Department of Ophthalmology, Jules Stein Eye ...
Vazquez JA +4 more
doaj
Beilstein Journal of Organic Chemistry, 2020 The one-pot reaction of chlorosulfonyl isocyanate (CSI) with epoxides having phenyl, benzyl and fused cyclic alkyl groups in different solvents under mild reaction conditions without additives and catalysts was studied.
Esra Demir +5 more
doaj +1 more source
Resistance to Linezolid Caused by Modifications at Its Binding Site on the Ribosome [PDF]
, 2012 Linezolid is an oxazolidinone antibiotic in clinical use for the treatment of serious infections of resistant Gram-positive bacteria. It inhibits protein synthesis by binding to the peptidyl transferase center on the ribosome. Almost all known resistance
Long, Katherine S., Vester, Birte
core +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2008 Triazolylmethyl oxazolidinones are novel potent antibacterial agents recently synthesized in our laboratory. PURPOSE. Development of a rapid and specific LC-MS method for evaluating the stability of three potentially active antibacterial triazolylmethyl ...
Oludotun A. Phillips +1 more
doaj +1 more source
Palladium-catalyzed formation of oxazolidinones from biscarbamates: a mechanistic study
Beilstein Journal of Organic Chemistry, 2011 Oxazolidinones can be synthesized starting from cyclic biscarbamates via a palladium-catalyzed reaction. To test the proposed mechanism of this reaction, first, bicyclonorcarene endoperoxides derived from cyano and carbomethoxy cycloheptatrienes were ...
Benan Kilbas, Metin Balci
doaj +1 more source
Scientia Pharmaceutica, 2018 Bacterial resistance towards the existing class of antibacterial drugs continues to increase, posing a significant threat to the clinical usefulness of these drugs.
Oludotun Adebayo Phillips +2 more
doaj +1 more source