Results 101 to 110 of about 6,381 (215)

Multicenter assessment of the linezolid spectrum and activity using the disk diffusion and Etest methods: report of the Zyvox® Antimicrobial Potency Study in Latin America (LA-ZAPS)

Brazilian Journal of Infectious Diseases, 2002
Linezolid was the first clinically applied member of the new antimicrobial class called the "oxazolidinones". These agents have a powerful spectrum of activity focussed against Gram-positive organisms including strains with documented resistances to ...
Ballow Charles H., Biedenbach Douglas J., Rossi Flavia, Jones Ronald N.   +3 more
doaj  

5-Benzylidene-4-Oxazolidinones are Synergistic with Antibiotics for the Treatment of Staphylococcus Aureus Biofilms

, 2019
The failure of frontline antibiotics in the clinic is one of the most serious threats to human health and requires a multitude of novel therapeutics and innovative treatment approaches to curtail the growing crisis. In addition to traditional resistance
Bram Frohock (7336071), Jennifer C. Daiker (7336077), Bram, Frohock, Jessica M. Gilbertie (7336074), Joshua, Pierce, Joshua Pierce (4354564), Jennifer C., Daiker, Lauren V., Schnabel, Lauren V. Schnabel (7336079), Jessica M., Gilbertie   +9 more
core   +1 more source

Synthesis of 2-Oxazolidinones from β-Lactams:  Stereospecific Total Synthesis of (−)-Cytoxazone and All of Its Stereoisomers

, 2016
The synthetic correlation between two different antibiotic frameworks, the β-lactams and 2-oxazolidinones, is described for the first time. In this approach, 2-oxazolidinones are prepared in stereomerically pure form from 3-hydroxy β-lactams by a ring ...
Cristina M. Coates (2318938), Kevin D. Revell (1858615), Edward Turos (1954960), Rajesh Kumar Mishra (2505943)   +3 more
core   +1 more source

Sm₂XMnO₆ (X = Co, Cr, and Fe) linked HPG on dendritic nanosilica as a recyclable green catalyst for eco-friendly synthesis of oxazolidinones from carbon dioxide

Journal of CO2 Utilization
In this work, Sm₂XMnO₆ (X = Co, Cr, Fe) nanocatalysts with high surface area and readily accessible active sites were successfully synthesized using a simple strategy based on dendritic fibrous nanosilica (DFNS).
Jianshan Li, Jiuzheng Yu, Rahele Zhiani
doaj   +1 more source

Absolute Configuration of Lactams and Oxazolidinones Using Kinetic Resolution Catalysts

, 2016
A simple method for determining the absolute configuration of oxazolidinones, lactams, and their derivatives using kinetic resolution catalysts is described.
Matthew A. Perry (1963963), Jonathan V. Trinidad (1997686), Scott D. Rychnovsky (1335972)   +2 more
core   +1 more source

Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents

ChemistryOpen
An efficient microwave‐assisted synthesis route for novel oxazolidinone analogues has been developed. The general synthesis of these compounds began with an L‐proline‐mediated three‐component Mannich reaction between commercially available 3‐fluoro‐4 ...
Secret P. Els, Kimberleigh B. Govender, Mxolisi K. Sokhela, Nilay Bhatt, Nakita Reddy, Hendrik G. Kruger, Per I. Arvidsson, Hendra Gunosewoyo, Thavendran Govender, Tricia Naicker   +9 more
doaj   +1 more source

In Vitro and In Vivo Activities of Three Oxazolidinones against Nonreplicating Mycobacterium tuberculosis

Oxazolidinones represent a new class of antituberculosis drugs that exert their function by inhibiting protein synthesis. Here, we compared the activities of three oxazolidinones, linezolid, PNU-100480, and AZD5847, against latent tuberculosis using a ...
Vocat, Anthony, Sambandamurthy, Vasan K., Sharma, Sreevalli, Cole, Stewart T., Balasubramanian, V., Sala, Claudia, Marriner, Gwendolyn, Zhang, Ming, Dhar, Neeraj   +8 more
core   +1 more source

Antimycobacterial Activities of Novel 5-(1H-1,2,3-Triazolyl)Methyl Oxazolidinones

, 2020
The antibacterial activities of a series of triazolyl oxazolidinones against Mycobacterium tuberculosis strain in vitro and in vivo in a mice model are presented.
Edet Ekpenyong Udo, Oludotun Adebayo Phillips, Reny Varghese   +2 more
core  

Multigram-Scale Preparation of Sugar-Based Spiro-Oxazolidinones

Oxazolidinones and their derivatives have attracted attention in various areas of drug development for antibacterial activity, herbicides, pesticides, and many other ...
Lugiņina, Jevgeņija, Rolava, Evija, Beļakovs, Sergejs, Rodins, Vitalijs, Turks, Māris   +4 more
core  

Palladium-Catalyzed Formation of Oxazolidinones from Biscarbamates: A Mechanistic Study

, 2020
Oxazolidinones can be synthesized starting from cyclic biscarbamates via a palladium-catalyzed reaction. To test the proposed mechanism of this reaction, first, bicyclonorcarene endoperoxides derived from cyano and carbomethoxy cycloheptatrienes were ...
Benan Kilbas, Metin Balci
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