Results 81 to 90 of about 2,355 (106)

Current Status and Perspectives of Antibacterial Agents Belonging to 2-Oxazolidinones

Pharmaceuticals
In the last three decades, 2-oxazolidinones have emerged as an important class of inhibitors of bacterial protein synthesis, effective in the treatment of multidrug-resistant (MDR) bacterial infections. From a public health perspective, the importance of
Jessica Ceramella, Annaluisa Mariconda, Domenico Iacopetta, Maria Marra, Alessia Catalano, Paola Checconi, Stefano Aquaro, Carmela Saturnino, Pasquale Longo, Maria Stefania Sinicropi   +9 more
doaj   +1 more source

Safety of long-term use of linezolid: results of an open-label study

Therapeutics and Clinical Risk Management, 2016
Jose A Vazquez,1 Anthony C Arnold,2 Robert N Swanson,3 Pinaki Biswas,3 Matteo Bassetti4 1Section of Infectious Diseases, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA; 2UCLA Department of Ophthalmology, Jules Stein Eye ...
Vazquez JA, Arnold AC, Swanson RN, Biswas P, Bassetti M   +4 more
doaj  

Novel and Highly Efficient Carboxylative Cyclization of CO₂ to 2-Oxazolidinones Using Nano-SiO₂-Supported Ionic Liquid Sustainable Catalysts

Molecules
The conversion of CO2 into 2-oxazolidinones through carboxylative cyclization with propargylic amines is considered an effective method for utilizing waste gas as a sustainable C1 resource and mitigating the greenhouse effect.
Yulin Hu, Zongyan Tang, Xiaobing Liu
doaj   +1 more source

One-pot synthesis of oxazolidinones and five-membered cyclic carbonates from epoxides and chlorosulfonyl isocyanate: theoretical evidence for an asynchronous concerted pathway

Beilstein Journal of Organic Chemistry, 2020
The one-pot reaction of chlorosulfonyl isocyanate (CSI) with epoxides having phenyl, benzyl and fused cyclic alkyl groups in different solvents under mild reaction conditions without additives and catalysts was studied.
Esra Demir, Ozlem Sari, Yasin Çetinkaya, Ufuk Atmaca, Safiye Sağ Erdem, Murat Çelik   +5 more
doaj   +1 more source

Determination Of Novel Antibacterial Triazolylmethyl Oxazolidinones Concentrations In Human Plasma By APCI-LC-MS: Application To Stability Study

Journal of Pharmacy & Pharmaceutical Sciences, 2008
Triazolylmethyl oxazolidinones are novel potent antibacterial agents recently synthesized in our laboratory. PURPOSE. Development of a rapid and specific LC-MS method for evaluating the stability of three potentially active antibacterial triazolylmethyl ...
Oludotun A. Phillips, Mohammed E. Abdel-Hamid   +1 more
doaj   +1 more source

Synthesis of Oxazolidinones from Epoxides and Isocyanates Catalysed by Aluminium Heteroscorpionate Complexes [PDF]

, 2016
The combination of an aluminium(heteroscorpionate) complex and tetrabutylammonium bromide acts as a highly efficient catalyst system for the synthesis of oxazolidinones from epoxides and isocyanates.
North, Michael, Michael North, José A. Castro‐Osma, Otero, Antonio, Lara-Sánchez, Agustín, Castro-Osma, José A., Amy Earlam, Agustín Lara‐Sánchez, Antonio Otero, Earlam, Amy   +9 more
core   +1 more source

Structure-Antibacterial Activity Relationships of N-Substituted-(d-/l-Alaninyl) 1H-1,2,3-Triazolylmethyl Oxazolidinones

Scientia Pharmaceutica, 2018
Bacterial resistance towards the existing class of antibacterial drugs continues to increase, posing a significant threat to the clinical usefulness of these drugs.
Oludotun Adebayo Phillips, Edet Ekpenyong Udo, Roselyn Jennifer D’silva   +2 more
doaj   +1 more source

Multicenter assessment of the linezolid spectrum and activity using the disk diffusion and Etest methods: report of the Zyvox® Antimicrobial Potency Study in Latin America (LA-ZAPS)

Brazilian Journal of Infectious Diseases
Linezolid was the first clinically applied member of the new antimicrobial class called the "oxazolidinones". These agents have a powerful spectrum of activity focussed against Gram-positive organisms including strains with documented resistances to ...
Charles H. Ballow, Douglas J. Biedenbach, Flavia Rossi, Ronald N. Jones   +3 more
doaj   +1 more source

Enantioenriched Oxazolidinones as Synthesis Scaffolds and Efforts towards the Total Synthesis of Marineosin A [PDF]

, 2018
Enantioenriched Oxazolidinones as Synthesis Scaffolds and Efforts towards the Total Synthesis of Marineosin Feng Lang, PhD University of Pittsburgh, 2018 The utility of enantioenriched oxazolidinones in the preparation of small chiral building ...
Lang, Feng
core  

Comparative In Vitro Drug Susceptibility Study of Five Oxazolidinones Against Mycobacterium tuberculosis in Hainan, China

Pathogens
Oxazolidinones, novel synthetic antibacterials, inhibit protein biosynthesis and show potent activity against Gram-positive bacteria, including Mycobacterium tuberculosis (MTB).
Jinhui Dong, Qian Cheng, Chuanning Tang, Yeteng Zhong, Jieying Wang, Meiping Lv, Zhuolin Chen, Peibo Li, Ming Luo, Hua Pei   +9 more
doaj   +1 more source