Results 61 to 70 of about 4,750 (178)
Brazilian Journal of Infectious DiseasesLinezolid was the first clinically applied member of the new antimicrobial class called the "oxazolidinones". These agents have a powerful spectrum of activity focussed against Gram-positive organisms including strains with documented resistances to ...
Charles H. Ballow +3 more
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Searching for Ideal Oxazolidinone for Treatment of Tuberculosis
Туберкулез и болезни лёгкихOxazolidinones represent a promising class of drugs for treatment of multidrug-resistant tuberculosis (MDR-TB). Linezolid, the first representative of this class, is highly effective; however, its use is limited due to its toxicity (myelosuppression ...
A. I. Gayda +5 more
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Antimicrobial activity of linezolid against Gram-positive cocci isolated in Brazil
Brazilian Journal of Infectious Diseases, 2001 The new oxazolidinone linezolid and other antimicrobial agents used to treat Gram-positive infections were tested against 1,585 Gram-positive cocci; 1,260 staphylococci and enterococci isolates from patients hospitalized in Brazilian hospitals, and 325 S.
Sader Helio S. +2 more
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New Oxazolidinones for Tuberculosis: Are Novel Treatments on the Horizon?
PharmaceuticsMultidrug-resistant tuberculosis (MDR-TB) is a global health concern. Standard treatment involves the use of linezolid, a repurposed oxazolidinone. It is associated with severe adverse effects, including myelosuppression and mitochondrial toxicity.
Ricky Hao Chen +4 more
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New and old oxazolidinones: tedizolid vs. linezolid [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2017 Tedizolid is a novel oxazolidinone that has been recently approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) caused by Gram-positive pathogens, including MRSA.
Dekhnich A.V., Hachatryan N.N.
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Brazilian Journal of Infectious Diseases, 2002 Linezolid was the first clinically applied member of the new antimicrobial class called the "oxazolidinones". These agents have a powerful spectrum of activity focussed against Gram-positive organisms including strains with documented resistances to ...
Ballow Charles H. +3 more
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An efficient chiral resolution of racemic baclofen using 2-oxazolidinones as chiral auxiliaries
Results in ChemistryAn efficient large-scale preparation of enantiomerically pure (R)- and (S)-baclofen hydrochloride is described. The principal feature of this approach is the practical resolution of N-Boc-protected baclofen using 2-oxazolidinones as chiral auxiliaries ...
Lili Yang +8 more
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Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents
ChemistryOpenAn efficient microwave‐assisted synthesis route for novel oxazolidinone analogues has been developed. The general synthesis of these compounds began with an L‐proline‐mediated three‐component Mannich reaction between commercially available 3‐fluoro‐4 ...
Secret P. Els +9 more
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