Results 61 to 70 of about 2,355 (106)

Truncation of Samroiyotmycin: Tailored seco‐Acids as Novel Antimalaria Compounds

European Journal of Organic Chemistry, Volume 29, Issue 34, 11 September 2026.
Six truncated samroiyotmycin‐derived antimalarials were synthesized by replacing the tosyloxazole unit with electron‐deficient aryl groups. The most active seco‐acid with EWG = 2 × CF3 outperformed the natural product SamA. Its enhanced activity supports a donor–acceptor interaction involving the electron‐poor aryl unit, consistent with inhibition of ...
Anton Czuczkowski, Anja Schäfer, Juliana A. Hüther, Bianca Wank, Robert Toews, Fotios Fotakis, Andreas Köhn, Markus Rehm, Matthias Rottmann, Anna Zens, Sabine Laschat   +10 more
wiley   +1 more source

3D QSAR studies of N-4-arylacryloylpiperazin-1-yl-phenyl-oxazolidinones: A novel class of antibacterial agents

, 2006
Three-dimensional QSAR studies for N-4-arylacryloylpiperazin-1-yl-phenyl-oxazolidinones were conducted using TSAR 3.3. The in vitro activities (MICs) of the compounds against Staphylococcus aureus ATCC 25923 exhibited a strong correlation with the ...
Neha Gandhi, Vidya Bhushan Lohray, Brijesh Kumar Srivastava, Srivastava, Brijesh Kumar, Gandhi, Neha, B.B. Lohray, Lohray, B. B., Lohray, Vidya Bhushan   +7 more
core   +1 more source

Convenient Synthesis of Oxazolidinones by the Use of Halomethyloxirane, Primary Amine, and Carbonate Salt

, 2016
Primary amines reacted with carbonate salts (Na2CO3, K2CO3, Cs2CO3, and Ag2CO3) and halomethyloxiranes in the presence of a base such as DBU or TEA to give oxazolidinones in high yields.
Yoshihiro Ida (2677675), Yuka Hikima (2677681), Yoko Sato (216594), Yumiko Osa (2677684), Hiroshi Nagase (719027), Shuichi Hirono (518775), Kouichi Takino (2677678)   +6 more
core   +1 more source

Photochemistry of oxazolidinones antibacterial drugs [PDF]

, 2009
The photochemistry of six N3-(3-fluoro-4-dialkylaminophenyl)-oxazolidinones known for their antimicrobial activity has been examined. All of these compounds are defluorinated in water (dec ≈ 0.25) and in methanol (dec ≈ 0.03), reasonably via the triplet.
Angelo Albini, TILOCCA, FEDELE, Elisa Fasani, Fedele Tilocca, FASANI, ELISA, ALBINI, ANGELO   +5 more
core   +1 more source

Design, Synthesis, In Silico Studies, and HIV‐1 RT Inhibitory Activity of 1,3‐Oxazolidine Pyrimidine Nucleoside Analogues

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Previously synthesized 1,3‐oxazolidine pyrimidine nucleoside analogues (S1–S6) were evaluated for HIV‐1 reverse transcriptase inhibition using molecular docking, ADMET prediction, and an in vitro colorimetric HIV‐RT assay. Compounds S4 and S5 exhibited the strongest binding affinities and moderate enzyme inhibition (IC50 = 19.27 and 22.80 µM ...
Shimoga Nagaraj Sriharsha, Zaid Mahmood Mohamed, Ammar A. Razzak Mahmood, Sibghatullah Muhammad Ali Sangi, Sadik Shaik, Sreeharsha Nagaraja, Sheeba Kumari, Vidhya Thirunavukkarasu, Pavan Kumar Sreenivasalu, Monirul Islam, Muhammad Shahzad Chohan, Mahalakshmi Suresha Biradar   +11 more
wiley   +1 more source

Silica sulfuric acid: a versatile and reusable heterogeneous catalyst for the synthesis of N-acyl carbamates and oxazolidinones under solvent-free conditions

Bulletin of the Chemical Society of Ethiopia, 2011
Silica sulfuric acid catalyzes efficiently the reaction of carbamates and oxazolidinones with anhydrides under solvent-free conditions. All the reactions were done at room temperature and the N-acyl carbamates and oxazolidinones were obtained with high ...
Liqiang Wu, Xiaojuan Yang, Fulin Yan
doaj  

(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one

Molbank, 2018
(S)-4-Isopropyl-5,5-diphenyloxazolidin-2-one has been synthesized for the first time by the enantiospecific oxidative carbonylation of commercially available (S)-2-amino-3-methyl-1,1-diphenylbutan-1-ol.
Raffaella Mancuso, Rossana Miliè, Ida Ziccarelli, Mariangela Novello, Nicola Della Ca’, Bartolo Gabriele   +5 more
doaj   +1 more source

Methamphetamine Enantiomers: From Chemical Synthesis to Biological Fate

Chirality, Volume 38, Issue 9, September 2026.
Methamphetamine is an amphetamine‐type stimulant characterized by a single stereogenic center, resulting in two enantiomers, (R)‐(−)‐methamphetamine and (S)‐(+)‐methamphetamine, with distinct biological and pharmacological profiles. These forms exhibit differences in central nervous system activity, metabolism, excretion, and overall physiological ...
Larissa Pires do Espírito Santo, Renato Lúcio de Carvalho, Juliana Almeida Sad, Pedro Henrique Costa dos Santos, Rhaiza Silva Domingues, Gabriele de Azevedo Cardoso, Karine Braga Enes, Gisele Assis Castro Goulart, Maila de Castro Lourenço das Neves, Ângelo de Fátima   +9 more
wiley   +1 more source

Stereodivergent Synthesis of C5‐α‐Substituted Linezolid Derivatives From D‐Mannitol and Structure–Antibacterial Activity Evaluation

Chirality, Volume 38, Issue 9, September 2026.
A stereodivergent route from D‐mannitol enables access to enantiopure C5‐α‐substituted linezolid analogues with full configurational control. Biological evaluation reveals that α‐substitution abolishes antibacterial activity irrespective of stereochemistry, establishing a strict steric limitation at C5 and highlighting the dominant role of substituent ...
José A. Gálvez, Laura Sanz‐Asensio, Ramón Badorrey, Jesús Gonzalo‐Asensio   +3 more
wiley   +1 more source

Design, Synthesis, Antimycobacterial Evaluation, and In Silico Investigation of Benzisothiazole‐Based Hydrazide Derivatives as Potential Anti‐Tuberculosis Agents

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
A novel series of benzisothiazole‐based hydrazide derivatives was designed, synthesized, and evaluated for antitubercular activity. Compound 8k emerged as the most potent candidate (MIC = 0.25 μg/mL) with a high selectivity index (SI = 42) and bactericidal activity. Molecular docking and 100 ns simulations identified InhA as the probable target.
Vivek Sharma, Arun Sharma, Ruchi Poria, Pardeep Kumar   +3 more
wiley   +1 more source