Results 51 to 60 of about 4,750 (178)
British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1845-1856, June 2026.Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen +4 more
wiley +1 more source
Contezolid in the Treatment of Multidrug‐Resistant Tuberculous Meningitis: A Case Report
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Multidrug‐resistant tuberculous meningitis (MDR‐TBM) has a high mortality rate, and treatment options are limited. Linezolid is recommended for refractory cases but often causes intolerable adverse reactions such as peripheral neuropathy. Contezolid, a novel oxazolidinone, has shown better safety profiles in preclinical and early clinical ...
Na Wang +10 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 6, June 2026.ABSTRACT Background and Aims Gram‐positive infections in burn patients present significant treatment challenges. This study compared the efficacy and safety of linezolid vs. teicoplanin for managing such infections in a clinical setting. Methods We conducted a retrospective study involving 77 burn patients with confirmed Gram‐positive infections at ...
Abolfazl Zendehdel +4 more
wiley +1 more source
Tetrahedron, 2012 Abstract Two new oxazolidinone polycyclitols, 4,5,7,8,9-pentahydroxy-3-tosyldecahydronaphtho [2,1-d]oxazol-2(9bH)-one and 4,5,6,7,8-pentahydroxy-3-tosyldecahydronaphtho [2,1-d]oxazol-2(9bH)-one were synthesized starting from p-benzoquinone. An endo selective Diels–Alder cycloaddition between p-benzoquinone and 1-acetoxybutadiene followed by ...
Kelebekli, Latif +2 more
openaire +3 more sources
PharmaceuticalsBackground: We recently synthesized a novel series of triazolyl-oxazolidinones (PH066, PH139, PH162, and PH166) that exhibited significant in vivo anticonvulsant activity in rat models of electrically- and chemically-induced seizures.
Mohsen A. Hedaya +5 more
doaj +1 more source
Safety of long-term use of linezolid: results of an open-label study
Therapeutics and Clinical Risk Management, 2016 Jose A Vazquez,1 Anthony C Arnold,2 Robert N Swanson,3 Pinaki Biswas,3 Matteo Bassetti4 1Section of Infectious Diseases, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA; 2UCLA Department of Ophthalmology, Jules Stein Eye ...
Vazquez JA +4 more
doaj
Beilstein Journal of Organic Chemistry, 2020 The one-pot reaction of chlorosulfonyl isocyanate (CSI) with epoxides having phenyl, benzyl and fused cyclic alkyl groups in different solvents under mild reaction conditions without additives and catalysts was studied.
Esra Demir +5 more
doaj +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2008 Triazolylmethyl oxazolidinones are novel potent antibacterial agents recently synthesized in our laboratory. PURPOSE. Development of a rapid and specific LC-MS method for evaluating the stability of three potentially active antibacterial triazolylmethyl ...
Oludotun A. Phillips +1 more
doaj +1 more source
Palladium-catalyzed formation of oxazolidinones from biscarbamates: a mechanistic study
Beilstein Journal of Organic Chemistry, 2011 Oxazolidinones can be synthesized starting from cyclic biscarbamates via a palladium-catalyzed reaction. To test the proposed mechanism of this reaction, first, bicyclonorcarene endoperoxides derived from cyano and carbomethoxy cycloheptatrienes were ...
Benan Kilbas, Metin Balci
doaj +1 more source
Scientia Pharmaceutica, 2018 Bacterial resistance towards the existing class of antibacterial drugs continues to increase, posing a significant threat to the clinical usefulness of these drugs.
Oludotun Adebayo Phillips +2 more
doaj +1 more source