Results 51 to 60 of about 17,792 (252)

Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims The study aims to develop a physiologically‐based pharmacokinetic (PBPK) model to quantitatively evaluate the role of ATP‐binding cassette sub‐family B member 1 (ABCB1) and ATP‐binding cassette super‐family G member 2 (ABCG2) in the drug–drug interaction (DDI) between rifampin and linezolid and to predict the impact of high‐dose rifampin ...
Hoang Dat Nguyen, Vinh Hoa Pham, Richard M. Hoglund, Joel Tarning, Junjie Ding   +4 more
wiley   +1 more source

Novel MCM-41 Supported Dicationic Imidazolium Ionic Liquids Catalyzed Greener and Efficient Regioselective Synthesis of 2-Oxazolidinones from Aziridines and Carbon Dioxide

Molecules, 2022
A type of MCM-41 supported dicationic imidazolium ionic liquid nanocatalyst has been synthesized and found to be competent for the synthesis of 2-oxazolidinones through the sustainable chemical conversion of CO2 with aziridines.
Yulin Hu, Lili Yang, Xiaobing Liu
doaj   +1 more source

Analysis of combined resistance to oxazolidinones and phenicols among bacteria from dogs fed with raw meat/vegetables and the respective food items [PDF]

, 2019
The gene optrA is the first gene that confers resistance to the oxazolidinone tedizolid, a last resort antimicrobial agent in human medicine. In this study we investigated the presence of optrA and the multi-resistance genes poxtA and cfr in enterococci ...
Fan, Run, Feßler, Andrea T., Lei, Lei, Schwarz, Stefan, Wang, Yang, Wang, Yinchao, Wang, Zheng, Wu, Congming, Wu, Yifan   +8 more
core   +1 more source

Metal Nanoparticles on Halloysite Applied in Stereoselective Hydrogenation of Tetrasubstituted Alkenes

Chemistry – A European Journal, EarlyView.
Composite materials based on metal nanoparticles supported on a naturally occurring nanotubular clay, halloysite (HAL), led to the diastereoselective hydrogenation of tetra‐substituted alkenes under relatively smooth conditions, mainly oxazolidinone‐based heterocycles.
Rosa Pich, Gabriel Domínguez, Leo Westrey, Pierre Lavedan, Sonia Mallet‐Ladeira, Jérôme Esvan, Jean‐François Lahitte, Jean‐Christophe Remigy, Daniel Pla, Montserrat Gómez   +9 more
wiley   +1 more source

Push–Pull Ynamines and Push–Pull Ynamides: Synthesis, Structure, Reactivity, and Application

European Journal of Organic Chemistry, EarlyView.
Push–pull ynamines and push–pull ynamides, which carry an EWG and an amino or amido group as EDG, are highly interesting classes of EDG‐EWG alkynes that have been intensively studied due to their exceptional reactivity. In this review, the synthesis, structure, reactivity, and application of push–pull ynamines, push–pull ynecarbamates, push–pull ...
Hans‐Joachim Gais
wiley   +1 more source

Synthesis of novel urethanes from a castor oil derived C22-acyloin [PDF]

, 2011
The synthesis of new bio-based chemical building blocks, resulting from the condensation of a renewable C-22 acyloin derived from non-edible castor oil, with mono- and bifunctional isocyanates is reported. The condensation with aliphatic mono-isocyanates
Stevens, Christian, Van der Steen, Marijke, Vilums, Maris   +2 more
core   +2 more sources

Stereoselective Chemoenzymatic Synthesis Metaraminol Involving Gold‐Catalysed Alkyne Hydration and Carbonyl Biotransamination

European Journal of Organic Chemistry, EarlyView.
A chemoenzymatic synthesis of (1R,2S)‐metaraminol was developed by combining gold(I)‐catalysed alkyne hydration and stereoselective biotransamination in a sequential one‐pot process. Various phenol protection strategies were considered in oxidation‐reduction sequences, providing access to enantiopure propargylic alcohols as starting materials for ...
Lorena Escot, Iván Lavandera, Vicente Gotor‐Fernández   +2 more
wiley   +1 more source

Integrated CO2 capture-fixation chemistry via interfacial ionic liquid catalyst in laminar gas/liquid flow [PDF]

, 2019
Simultaneous capture of carbon dioxide (CO2) and its utilization with subsequent work-up would significantly enhance the competitiveness of CO2-based sustainable chemistry over petroleum-based chemistry.
Babu, A.G., Hwang, Y.-H., Kim, D.-P., Kim, J.-O., Ko, D.-H., Singh, A.K., Vishwakarma, N.K.   +6 more
core   +1 more source

Reduction‐Controlled Tunable Synthesis of Covellite (CuS) Nanoparticles from Water‐Soluble Single‐Source Precursors

Small, EarlyView.
Amino acid‐derived Cu(II)‐dithiocarbamates were synthesized as water‐soluble single‐source precursors for low‐temperature hydrothermal decomposition toward covellite (CuS) nanoparticles. Their decomposition followed a reduction‐mediated pathway via Cu(I)‐dithiocarbamate intermediates, with the reduction step being rate‐limiting and readily tunable ...
Xiang Xu, Siqiao Huang, Desmond A. Koomson, Tannith‐Jade Cole, Yuanyang Xie, Jagodish C. Sarker, David Pugh, Cécile A. Dreiss, Graeme Hogarth   +8 more
wiley   +1 more source

Role of therapeutic drug monitoring in pulmonary infections : use and potential for expanded use of dried blood spot samples [PDF]

, 2015
Respiratory tract infections are among the most common infections in men. We reviewed literature to document their pharmacological treatments, and the extent to which therapeutic drug monitoring (TDM) is needed during treatment.
Akkerman, Onno W, Alffenaar, Jan-Willem C, Bolhuis, Mathieu S, Hofman, Susan, Koster, Remco A, Stove, Christophe, van Assen, Sander   +6 more
core   +2 more sources