Results 41 to 50 of about 63,855 (231)

Parametric population pharmacokinetics of linezolid: A systematic review

British Journal of Clinical Pharmacology, 2022
Linezolid is often used for the infections caused by drug‐resistant Gram‐positive bacteria. Recent studies suggest that large between‐subject variability (BSV) and within‐subject variability could alter drug pharmacokinetics (PK) during linezolid therapy
Yan Qin, Li-li Zhang, Yanrong Ye, Yue-Ting Chen, Z. Jiao   +4 more
semanticscholar   +1 more source

Linezolid-Resistant Enterococcus spp. Isolates from Foods of Animal Origin—The Genetic Basis of Acquired Resistance

Foods, 2022
Enterococci are important opportunistic pathogens with the capacity to acquire and spread antibiotic resistance. At present, linezolid-resistant enterococci (LRE) pose a great challenge.
Urszula Zarzecka, A. Zakrzewski, Wioleta Chajȩcka-Wierzchowska, Anna Zadernowska   +3 more
semanticscholar   +1 more source

Linezolid dose adjustment according to therapeutic drug monitoring helps reach the goal concentration in severe patients, and the oldest seniors benefit more

BMC Infectious Diseases, 2023
Background The elderly with severe infection increased dramatically in intensive care unit (ICU). Proper antimicrobial therapy help improve the prognosis.
Ying Xu, Xilan Yang, Pei Liang, Chen Qu
doaj   +1 more source

Proposed Linezolid Dosing Strategies to Minimize Adverse Events for Treatment of Extensively Drug-Resistant Tuberculosis

Clinical Infectious Diseases, 2021
Background We evaluated Nix-TB trial data (NCT02333799, N = 109) to provide dosing recommendations to potentially minimize linezolid toxicity in patients with extensively drug-resistant tuberculosis. .
M. Imperial, J. Nedelman, F. Conradie, Rada Savic   +3 more
semanticscholar   +1 more source

Mechanism underlying linezolid-induced peripheral neuropathy in multidrug-resistant tuberculosis

Frontiers in Pharmacology, 2022
Multidrug-resistant tuberculosis (MDR-TB) remains a main global health concern as there is no comprehensive therapeutic intervention yet and numerous adverse effects follow the therapeutic process.
Yuan Yuan, Jinmeng Li, Yanhong Chen, Qingshan Cai, Yingying Xu, Luting Lin, Yazhen Lang, Suhang Guo, Ruoying Zhang, Xinjun Cai   +9 more
doaj   +1 more source

Linezolid-related adverse drug reactions in patients with drug-resistant tuberculosis: A retrospective study at a government lung hospital [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Drug-resistant tuberculosis (DR-TB) remains a major public health challenge in Indonesia. Treatment outcomes are often compromised by adverse drug reactions (ADRs), particularly those related to prolonged linezolid use.
Emy Oktaviani, Kusnandar Anggadiredja, Lia Amalia   +2 more
doaj   +1 more source

Pan-European early switch/early discharge opportunities exist for hospitalised patients with methicillin-resistant Staphylococcus aureus complicated skin and soft-tissue infections [PDF]

, 2014
The objective was to document pan-European real-world treatment patterns and healthcare resource use and estimate opportunities for early switch (ES) from intravenous (IV) to oral antibiotics and early discharge (ED) in hospitalised patients with ...
Solem, C.T., Haider, S., Macahilig, C., D. Simoneau, W. Lawson, C. Macahilig, Li, J.Z., Stephens, J.M., J.Z. Li, C. Eckmann, S. Haider, R. Chambers, J.M. Stephens, Simoneau, D., Eckmann, C., D. Nathwani, Lawson, W., C.T. Solem, Nathwani, D., Chambers, R., Li, J. Z.   +20 more
core   +1 more source

Penetration of linezolid into bone tissue 24 h after administration in patients with multidrug-resistant spinal tuberculosis.

PLoS ONE, 2019
BackgroundLinezolid has shown strong antimicrobial activity against multidrug-resistant (MDR)/rifampin-resistant strains of Mycobacterium tuberculosis.
Yuan Li, Hairong Huang, Weijie Dong, Tinglong Lan, Jun Fan, Shu'an Wen, Tingting Zhang, Shibing Qin, Ai Guo   +8 more
doaj   +1 more source

Immediate and Delayed Hypersensitivity Reactions to Antibiotics: Aminoglycosides, Clindamycin, Linezolid, and Metronidazole

Clinical reviews in allergy and immunology, 2021
Hypersensitivity reactions including IgE-mediated and delayed cell-mediated reactions to aminoglycosides, clindamycin, linezolid, and metronidazole are rare.
Michelle Dilley, B. Geng
semanticscholar   +1 more source

Safety and tolerability of linezolid

, 2003
Clinical trials have shown that linezolid (600 mg twice daily in adults) is safe and generally well tolerated for up to 28 days. Drug-related adverse events, which are typically mild to moderate in intensity and of limited duration, include diarrhoea ...
French, G, G. French
core   +6 more sources