Results 81 to 90 of about 41,531 (223)

Pharmacokinetics of PP353, a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first‐in‐human, Phase 1b, open‐label, single‐dose study

JOR Spine
Background Bacterial infection of the intervertebral disc is difficult to treat because the tissue is usually not vascularized and systemic antibiotic therapy may not reach optimal antibacterial exposure.
Shiva S. Tripathi, Robert Sneath, Aprajay Golash, Parag Desai, Duncan McHale, Sarah Guest, Charlie Brindley, Paul Cummings, Shane Smith, Conrad Stroud, Graham Scott, Steve Ruston, Lloyd Czaplewski   +12 more
doaj   +1 more source

Epidemiological characteristics and genetic structure of linezolid-resistant Enterococcus faecalis

, 2018
Meijuan Chen,1 Hongying Pan,1 Yaling Lou,2 Zhe Wu,3 Jiajie Zhang,1 Yicheng Huang,1 Wei Yu,1,3,* Yunqing Qiu3,* 1Department of Infectious Diseases, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou,
Pan H, Qiu Y, Wu Z, Huang Y, Zhang J, Chen M, Lou Y, Yu W   +7 more
core  

Linezolid-Induced Pure Red Cell Aplasia: A Case Report

, 2022
Xiao-Yan Yang, Lin Chen, Ji-Na Gu, Cheng-Jun Zeng, Dan-Mei Pan Infectious Diseases Department, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, 315010, People’s Republic of ChinaCorrespondence: Lin Chen, Infectious Diseases department,
Pan DM, Zeng CJ, Chen L, Gu JN, Yang XY
core  

Clinicopathological Features and Postoperative Complication Management of a Postauricular Granular Cell Tumor: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Postauricular granular cell tumors mimic parotid malignancies. Their resection disrupts fragile local microcirculation due to inherently thin skin and limited subcutaneous buffer, triggering ischemic necrosis and MRSE infection. Clinicians must prioritize functional tissue preservation and vigilant wound care to prevent these severe ...
Haotong Yuan, Chunhong Wang, Luran Wang, Dongxu Liu, Li Gao   +4 more
wiley   +1 more source

The Effect of Linezolid Therapy Duration on The Occurrence of Toxic Optic Neuropathy

Aksona
Highlight: • The occurence of toxic optic neuropathy in this study was similar to the occurence of anemia. • Discontinuation of Linezolid therapy improves visual disturbance • Linezolid therapy duration to cause TON in this study varies ...
Quinamora Estevan Sutantyo, Lukisiari Agustini, Tutik Kusmiati, Ariani Permatasari   +3 more
doaj   +1 more source

High accumulation of linezolid and its major metabolite in the serum of patients with hepatic and renal dysfunction is significantly associated with thrombocytopenia and anemia

Microbiology Spectrum
This study aims to examine the serum levels of linezolid and its metabolites (PNU-142300 and PNU-142586) in patients with varying hepatic and renal function.
Junqiang Gou, Qian Li, Ning Fan, Chen Zhang, Haiwen Tang, Xiaofeng Wang, Dongfeng Yin   +6 more
doaj   +1 more source

Clinical update on linezolid in the treatment of Gram-positive bacterial infections

, 2012
Sally Ager, Kate GouldDepartment of Microbiology, Newcastle upon Tyne Hospitals Trust, Freeman Hospital, High Heaton, Newcastle upon Tyne, UKAbstract: Gram-positive pathogens are a significant cause of morbidity and mortality in both community and health
Ager S, Gould K
core  

Safety and tolerability of linezolid

, 2003
Clinical trials have shown that linezolid (600 mg twice daily in adults) is safe and generally well tolerated for up to 28 days. Drug-related adverse events, which are typically mild to moderate in intensity and of limited duration, include diarrhoea ...
French, G, G. French
core   +1 more source

The ‘Health Collapse Spiral’: A 35‐Month Longitudinal Case Study of Physiological Reserve Depletion in a Centenarian Following COVID‐19

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT This 35‐month case report documents irreversible physiological reserve depletion in a centenarian multimorbid man after COVID‐19. Prior to infection, he maintained precarious homeostasis for 17 years despite severe frailty (CFS 7), with stable CKD stage 3a (eGFR 58.3 mL/min/1.73 m2) and albumin 36.2 g/L.
Shan Xu, Wei Zhang, Qiaoxiang Yin, Jie Wei, Yanmin Ma, Wenwen Jia   +5 more
wiley   +1 more source

Combined Use of Broad-Spectrum Antibiotics in Phthisiology

Фундаментальная и клиническая медицина
Aim. To investigate pharmacokinetic and pharmacodynamic interactions of levofloxacin, kanamycin and linezolid in combined chemotherapy of multidrug-resistant tuberculosis.Materials and Methods.
D. S. Vailenko, T. P. Tananakina, Yu. G. Pustovoy, V. V. Baranova, V. I. Shmatkov, A. R. Zanin   +5 more
doaj   +1 more source